Inulin: properties and health benefits

Qin, Yu-Qing; Wang, Liu-Yan; Yang, Xinyu; Xu, Youren; Fan, Gang; Fan, Yange; Ren, Jianmin; An, Qi; Li, Xiao

doi:10.1039/d2fo01096h

Cited by 51 publications

(21 citation statements)

References 136 publications

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“…These 2 polysaccharides are widely known for their antiinflammatory properties. 16,43 We found that both could reverse the increases in ALT, TNFα, and TGFβ1, but only oat βglucan could lower the liver index, AST, and insulin. The improvement in liver injury and hepatic inflammation resulting from oat β-glucan and inulin supplementation was consistent with previous studies that investigated their capability to prevent NAFLD, 24,26,44 implying that these 2 polysaccharides can be utilized in NAFLD prevention and treatment.…”

Section: Discussionmentioning

confidence: 72%

Effects of Oat β-Glucan and Inulin on Alleviation of Nonalcoholic Steatohepatitis Aggravated by Circadian Disruption in C57BL/6J Mice

Kei,

Cheung,

et al. 2024

J. Agric. Food Chem.

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This was the first study that examined the effects of oat β-glucan and inulin on diet-induced nonalcoholic steatohepatitis (NASH) in circadian-disrupted (CD)-male C57BL/6J mice. CD intensified NASH, significantly increasing alanine aminotransferase and upregulating hepatic tumor necrosis factor α (TNFα) and transforming growth factor β 1 (TGFβ1). However, these observations were significantly alleviated by oat β-glucan and inulin treatments. Compared to CD NASH mice, oat β-glucan significantly decreased the liver index, aspartate aminotransferase (AST), and insulin. In prebiotic-treated and CD NASH mice, significant negative correlations were found between enrichment of Muribaculaceae bacterium Isolate-036 (Harlan), Muribaculaceae bacterium Isolate-001 (NCI), and Bacteroides ovatus after oat β-glucan supplementation with TNFα and TGFβ1 levels; and enrichment of Muribaculaceae bacterium Isolate-110 (HZI) after inulin supplementation with AST level. In conclusion, oat β-glucan and inulin exhibited similar antiliver injury, anti-inflammatory, and antifibrotic activities but had no effect on cecal short-chain fatty acids and gut microbiota diversity in CD NASH mice.

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Section: Discussionmentioning

confidence: 72%

Effects of Oat β-Glucan and Inulin on Alleviation of Nonalcoholic Steatohepatitis Aggravated by Circadian Disruption in C57BL/6J Mice

Kei,

Cheung,

et al. 2024

J. Agric. Food Chem.

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“…Fermentation of dietary components and their gut microbiome and metabolome effects are often investigated in isolation, whereas product formulations often contain blends of several functional ingredients. For example, research has been separately conducted on the beneficial effects of prebiotic fibers (Makki et al ., 2018; Qin et al ., 2023) and to a lesser extent for botanicals (Cefalu, Ye and Wang, 2008; Choi et al ., 2020; Xu et al ., 2022) but, to our knowledge, no research is published on the synergistic effects of both functional ingredient categories. To this end, we investigated this concept by employing OLIPOP, a widely consumed functional soda containing a mixture of 3 fibers and 4 botanicals, in in vitro fermentations of the prebiotic fibers in OLIPOP with and without the paired botanicals.…”

Section: Discussionmentioning

confidence: 99%

Botanicals impact the bifidogenic effect and metabolic outputs ofin vitrofiber fermentation by gut-derived microbiota in individual-specific ways

Deemer

Voreades²,

Goodwin³

et al. 2023

Preprint

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Modern diets typically contain dramatically lower fiber content compared to traditional hunter-gatherer and agrarian diets, and this trend is paralleled by an enhanced frequency of chronic diseases. Despite national nutrition policy and education instructing Americans on the beneficial health value of increasing daily fiber consumption, a 'fiber gap' still persistently exists. Fortification of product groups frequently consumed by a large proportion of society provides an attractive strategy to close this 'fiber gap' and may have the potential to concomitantly reverse the detrimental health effects exacerbated by our modern diets. Besides prebiotic fibers, products can contain several other functional components, such as botanicals. However, the vast majority of studies have investigated functional components in isolation. For instance, preferential fermentation of specific prebiotic fibers by bifidobacteria has been clearly established, both in terms of their increased abundance in the gut microbiome and the elevated levels of beneficial metabolites, including short chain fatty acids (SCFAs) produced directly (acetate) or through interactions with other microbiota members (resulting in butyrate and propionate production). The impact of other components present in functional product blends on this bifidogenic effect are largely unexplored. Here, we investigated the fiber and botanical blends included in OLIPOP, a functional soda, in an in vitro gut fermentation model. Our data revealed that the blend of inulins and resistant dextrins promoted growth of bifidobacteria across gut microbiota from four donors, even those with small initial populations. In addition, botanicals interacted with fiber fermentation in donor-specific ways, in some cases strongly enhancing fermentation rate and production of SCFAs. Our data suggest that botanicals can modify the rate and microbial and metabolic fates of prebiotic fiber fermentation, and suggest that future studies should examine such interactions in greater detail.

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“…73 In addition, inulin also exhibits excellent health benefits in glycolipid metabolism, inhibiting the expression of inflammatory factors, enhancing mineral absorption, and improving constipation. 74 The structure of related polysaccharide compounds is shown in Figure 4.…”

Section: Saccharidesmentioning

confidence: 99%

Research Progress on the Homologous Effects of Cichorium glandulosum Boiss. et Huet on Medicine and Food: A Review

Yang,

Lei,

Yan

et al. 2024

Natural Product Communications

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Cichorium glandulosum Boiss. et Huet is a genus of chicory in the family of Asteraceae, and it is a “medicine food homology” herbal medicine, which has the effect of detoxifying heat, diuretic and swelling, and strengthening the stomach. This paper reviews the chemical composition, pharmacological effects, and practical applications of Cichorium glandulosum Boiss. et Huet and provides a comprehensive account of its role in human health and diet, pharmacological activities, and toxicity. Cichorium glandulosum Boiss. et Huet, “medicine food homology” herbal medicine, is often widely used in compound formulations with functions such as clearing the liver, promoting gallbladder, and enhancing immunity. Previous studies have found that multiple chemical components have been isolated and identified from Cichorium glandulosum Boiss. et Huet, mainly including 89 compounds such as flavonoids, terpenoids, phenolic acids, polysaccharides, and phenylpropanoids. Meanwhile, the extract has various biological activities, including hepatoprotective and hypoglycemic, regulating blood lipids, aiding digestion, anticancer, regulating intestinal microbiota and immune function, antioxidant, and has been proven in both in vivo and in vitro studies. As an important plant resource, the current research focuses on the traditional efficacy of Cichorium glandulosum Boiss. et Huet. The chemical composition of this genus of plants is complex and their pharmacological activities are diverse. Further in-depth studies on the molecular mechanisms and toxic side effects of its specific compounds in the organism are needed. Therefore, this review provides a reference for the development and utilization of Cichorium glandulosum Boiss. et Huet.

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Inulin: properties and health benefits

Abstract: Inulin, as a soluble dietary fiber, is widely found in beyond 36,000 plant species as reserve polysaccharides. The primary sources of inulin include Jerusalem artichoke, chicory, onion, garlic, barley, and...

Cited by 51 publications

References 136 publications

Effects of Oat β-Glucan and Inulin on Alleviation of Nonalcoholic Steatohepatitis Aggravated by Circadian Disruption in C57BL/6J Mice

Effects of Oat β-Glucan and Inulin on Alleviation of Nonalcoholic Steatohepatitis Aggravated by Circadian Disruption in C57BL/6J Mice

Botanicals impact the bifidogenic effect and metabolic outputs ofin vitrofiber fermentation by gut-derived microbiota in individual-specific ways

Research Progress on the Homologous Effects of Cichorium glandulosum Boiss. et Huet on Medicine and Food: A Review

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