Intussusception Risk and Disease Prevention Associated With Rotavirus Vaccines in Australia's National Immunization Program

Carlin, John B.; Macartney, Kristine; Lee, Katherine J.; Quinn, Helen; Buttery, James Peter; Lopert, Ruth; Bines, Julie E; McIntyre, Peter

doi:10.1093/cid/cit520

Cited by 176 publications

(146 citation statements)

References 29 publications

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“…Title and abstract screening resulted in the identification of 16 potentially relevant publications. Ten of these 16 studies met the inclusion criteria for the meta-analysis (Table 1) (18,(26)(27)(28)(29)(30)(31)(32)(33)(34). The publications not included in the full text screening are listed as references e2-e7.…”

Section: Resultsmentioning

confidence: 99%

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Risk of Intussusception After Rotavirus Vaccination

Koch¹,

Harder²,

Kries³

et al. 2017

Deutsches Ärzteblatt International

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SUMMARYBackground: In 2013, the German Standing Committee on Vaccination (Stän-dige Impfkommission, STIKO) recommended rotavirus (RV) vaccination for all infants while stating that this mildly increased the risk of intussusception, a potentially life-threatening event. Since this recommendation was issued, multiple observational studies on this topic designed as self-controlled case series (SCCS) have been published. The SCCS design is particularly suitable for the study of rare adverse effects of medications.

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Section: Resultsmentioning

confidence: 99%

“…Of the 10 studies included in the review, 7 provided data on the risk of intussusception after RV1 vaccination (18, 26, 29, 30, 32-34) and 4 on the risk after RV5 (27,29,31,34). One study reported only the results for both vaccines together (28).…”

Section: Study Characteristicsmentioning

confidence: 99%

Risk of Intussusception After Rotavirus Vaccination

Koch¹,

Harder²,

Kries³

et al. 2017

Deutsches Ärzteblatt International

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“…This risk was shown to be proportional to the time from birth to first dose with delayed dosing resulting in an increased risk of life-threatening intussusception [7]. Although pre-licensure studies showed no significant increase in intussusception for both current vaccines compared with placebo, data now suggest there is an increased risk, albeit substantially lower than with RotaShield [8,9]. The risk of intussusception following current RV vaccines administered within the correct time window is 1.5-6 per 100,000 compared with a 10-fold higher risk of 1 per 10,000 with RotaShield.…”

Section: Rv Vaccines -The Importance Of Timely Immunizationmentioning

confidence: 99%

Use of rotavirus vaccines in preterm babies on the neonatal unit

Kilich

Sadarangani

2016

Expert Review of Vaccines

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“…15 This is likely attributable to the reluctance of some pediatricians and public health physicians to recommend rotavirus vaccination due to a slight increase of intussusception among children vaccinated with RV1 and RV5, which was observed in other countries, especially after the first dose. 16 …”

Section: Introductionmentioning

confidence: 99%

Universal rotavirus vaccination program in Sicily: Reduction in health burden and cost despite low vaccination coverage

Costantino

Restivo

Tramuto

et al. 2018

Human Vaccines & Immunotherapeutics

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Rotavirus is considered the main cause of severe gastroenteritis and nosocomial infections in Pediatric units, especially during late winter and early spring season in temperate region. In 2013 Sicilian Region, for the first time in Italy, introduced universal Rotavirus vaccination. This study aims to estimate health and economic impact on rotavirus Gastroenteritis (RVGE) among children aged 0–59 months in Sicily, after rotavirus vaccine introduction.We analyzed hospital discharge records including a diagnosis of RVGE occurred from 1st January 2009 to 31st December 2016 among hospitalized children aged 0 to 59 months, residents in Sicily. RVGEs were defined as all hospitalizations with an ICD-9-CM diagnosis code of 008.61 on first or any diagnosis position. Also an economic impact analysis on Health Regional System was conducted.We observed a consistent decline of hospitalization after rotavirus vaccination introduction from 394 per 100,000 in 2009–2012 to 220 per 100,000 in 2013–2016. We found a change in the peak of reported cases by at least one month from March-April in the pre-vaccination period to May-June in the post-vaccination period. Since 2013, we estimated that the annual average cost saved is 1,134,056 € when considering direct and indirect costs to health care as well as vaccination costs.Our study is the first analysis conducted as far as we are aware in a high-income setting with poor coverage (lower than 50%), demonstrating a significant reduction of RVGE hospitalizations in Sicily after vaccine introduction. Moreover, was observed a consistent impact of vaccination on health care cost saving.

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Intussusception Risk and Disease Prevention Associated With Rotavirus Vaccines in Australia's National Immunization Program

Cited by 176 publications

References 29 publications

Risk of Intussusception After Rotavirus Vaccination

Risk of Intussusception After Rotavirus Vaccination

Use of rotavirus vaccines in preterm babies on the neonatal unit

Universal rotavirus vaccination program in Sicily: Reduction in health burden and cost despite low vaccination coverage

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