Intussusception of the Small Intestine Caused by a Primary Melanoma?

Schoneveld, Martijn; Vogelaere, Kristel De; Winkel, Nele Van De; Hoorens, Anne; Delvaux, Georges

doi:10.1159/000335882

Cited by 11 publications

(9 citation statements)

References 9 publications

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“…Although a limited number of studies, intestinal obstruction secondary to intussusception is the most frequent clinical presentation of primary melanoma. 1,9,10,11,12 The presentation of our patient was ileocecal intussusception due to metastatic melanoma of the intestines.…”

Section: Discussionmentioning

confidence: 94%

Ileocecal Intussusception Secondary to Bowel Metastases from Cutaneous Melanoma: Case Report

Yücel¹,

Filiz²,

Kurt³

et al. 2017

TJCD

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Altmış üç yaşındaki erkek hasta karın ağrısı, kanlı dışkılama, bulantı ve kusma şikayetleri ile hastaneye müracaat etti. Yapılan muayene ve tetkiklerinde; bilgisayarlı tomografide intestinal intussusepsiyon ve karın içi lenf düğümleri saptandı. Kolonoskopik inceleme sonrası redüksiyon sağlanamadı. Laparotomide, çekuma invajine ince barsak segmentleri redükte olmaması üzerine sağ hemikolektomi ve palpasyonda ince barsakta lümen içi saptanan tümöral kitleleri içine alan 60 cm ince barsak segmenti rezeke edildi. Patolojik inceleme sonrasında kolonda 1 ve ince barsaklarda 8 toplamda 9 adet polipoid lezyon saptandı. Histolojik incelemede sitoplazmik melanin birikimi ile epiteloid ve iğsi tümör hücreleri izlendi. İmmünohistokimyasal boyamada tümör hücrelerinde S-100, HMB-45 ve melan-A pozitif olarak bulundu. Moleküler incelenmesi BRAF geni 15 Ekzonlar c.1799> a (p.v600 A) mutasyon saptanan hastanın malign melonom olarak rapor edilmesi sonrası hasta yeniden değerlendirildi ve göğüs ön duvarında deride malign melanom saptandı. Anahtar Kelimeler: İntussusepsiyon, metastaz, melanom ÖZ ABSTRACTA 63-year-old man presented to the emergency department with abdominal pain, episodes of bloody stool, nausea, and vomiting. Abdominal computed tomography showed lower intestinal intussusception and enlarged lymph nodes. Colonoscopic reduction was not possible. Exploratory laparotomy revealed a 15-cm mass comprised of the ileocecal region that had intussuscepted secondary to the small bowel. Palliative right hemicolectomy and resection of 60 cm segments of the small bowel were performed. Pathologic examination of the excised specimen revealed polypoid masses. There were 9 polyps, 1 in the ascending colon and the others in the ileum. Histopathological examination demonstrated obvious features of melanoma associated with epitheloid and spindle tumor cells and cytoplasmic melanin deposition. The tumor cells showed positivity for S-100, HMB-45 and Melan-A. Molecular examination revealed a c.1799> A (p.v600 A) mutation in exon 15 of the BRAF gene. The patient was re-examined and a nevus was found on the left anterior chest wall.

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Section: Discussionmentioning

confidence: 94%

Ileocecal Intussusception Secondary to Bowel Metastases from Cutaneous Melanoma: Case Report

Yücel¹,

Filiz²,

Kurt³

et al. 2017

TJCD

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“…Although small and large intestines typically contain no melanocytes, a few theories try to explain the origin of melanoma in the bowel. 4 , 7 The occurrence of primary colonic melanoma (PCM) – an extremely rare tumor of the gastrointestinal tract – could be explained by the fact that melanocytes have occasionally been found in the digestive and respiratory tracts. 7 Tumor regression could be another explanation for the occurrence of "metastatic melanoma in the colon" with unknown primary site.…”

Section: Discussionmentioning

confidence: 99%

“… 4 , 7 The occurrence of primary colonic melanoma (PCM) – an extremely rare tumor of the gastrointestinal tract – could be explained by the fact that melanocytes have occasionally been found in the digestive and respiratory tracts. 7 Tumor regression could be another explanation for the occurrence of "metastatic melanoma in the colon" with unknown primary site. Infection or other changes in the immune system can be associated with spontaneous regression of the melanomas' primary site.…”

Section: Discussionmentioning

confidence: 99%

Melanoma as a surprising solution to the puzzle of intestinal obstruction

Gajda

Kamińska‐Winciorek

Grzesiak

et al. 2016

An. Bras. Dermatol.

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We present a case of a 71-year-old man with an advanced melanoma of the right colon. The final diagnosis was determined based on histopathological examination of the material collected during urgent laparotomy performed due to ileus. Although we considered the tumor to be a disseminated primary melanoma of the colon, the possibility of unknown primary origin could not be excluded. Palliative chemotherapy and radiotherapy reduced symptoms associated with the disease and prolonged patient's survival.

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“…Cutaneous melanoma arises from transformed melanocytes and can appear anywhere that melanocytes have migrated from during embryogenesis. The eyes [81], central nervous system [82], gastrointestinal tract [83,84], and even the gallbladder [85] have been reported as primary sites of the disease. More than 90% of melanomas are found on the skin and four percent are discovered as metastases without an identifiable primary site.…”

Section: Clinical Diagnosismentioning

confidence: 99%

Melanoma Review: Epidemiology, Risk Factors, Diagnosis and Staging

Arrangoiz¹

2016

JCTR

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Study Aim: Cutaneous melanoma accounts for approximately 4% of all skin cancers diagnosis each year in the USA but is responsible for 75% of skin cancer deaths. Physicians need to have an up to date knowledge about the epidemiology, risk factors, and clinical features of melanoma in order to make an early diagnosis and provide appropriate management decisions to improve survival in this aggressive malignancy. We will be presenting an extensive, up to date, literature review of cutaneous melanoma including the epidemiology, risk factors, diagnosis and staging. Method: An extensive literature review was performed using the following search engines: Pubmed, Ovid, Miromedex, and Dynamed. We limited our literature search to research papers written in English using the following keywords: cutaneous melanoma, epidemiology of melanoma, risk factors for melanoma, diagnosis of melanoma, clinical classification and staging of melanoma. Results: As a result of our extensive literature review we present an up to date review on the epidemiology, pathogenesis, risk factors, diagnosis, classification and staging of cutaneous melanoma. Conclusion: Physicians need to have an up to date knowledge about the epidemiology, risk factors, and clinical features in order to make an early diagnosis and provide appropriate management decisions in order to improve the survival patients with this aggressive malignancy.

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Intussusception of the Small Intestine Caused by a Primary Melanoma?

Cited by 11 publications

References 9 publications

Ileocecal Intussusception Secondary to Bowel Metastases from Cutaneous Melanoma: Case Report

Ileocecal Intussusception Secondary to Bowel Metastases from Cutaneous Melanoma: Case Report

Melanoma as a surprising solution to the puzzle of intestinal obstruction

Melanoma Review: Epidemiology, Risk Factors, Diagnosis and Staging

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