Intussusception as a complication of rotavirus infection in children

Grzybowska-Chłebowczyk, Urszula; Kałużna-Czyż, Monika; Kalita, Barbara; Gruszczyńska, Katarzyna; Więcek, Sabina; Dębowska, Monika; Chlebowczyk, Wojciech; Woś, Halina

doi:10.1016/j.pepo.2015.08.004

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…64 In 1998, a vaccine designed to prevent rotavirus gastroenteritis was associated with childhood intussusception after being vaccinated. 65 , 66 Finally, in the early 2000s, a hepatitis B vaccine product was linked to multiple sclerosis. 67 …”

Section: Discussionmentioning

confidence: 99%

Determinants of COVID-19 vaccine-induced myocarditis

Rose,

Hulscher,

McCullough

2024

Therapeutic Advances in Drug Safety

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Background: Following the roll-out of the Pfizer-BioNTech BNT162b2, Moderna mRNA-1273, and Janssen Ad26.COV2.S coronavirus disease 2019 (COVID-19) injections in the United States, millions of individuals have reported adverse events (AEs) using the vaccine adverse events reports system (VAERS). The objective of this analysis is to describe the myocarditis data in VAERS and the COVID-19 vaccines as potential determinants of myocarditis. Methods: We used VAERS data to examine the frequency of reporting myocarditis since the beginning of the mass vaccination campaign and compared this with historical values in VAERS and COVID-19 vaccine administration data from the Our World in Data database. We examined myocarditis reports in VAERS in the context of sex, age, and dose. Statistical analysis was done using the Student’s t-test to determine statistically significant differences between ages among myocarditis adverse events (AEs) and the chi-square test to determine relationships between categorical variables with statistical significance. Results: We found the number of myocarditis reports in VAERS after COVID-19 vaccination in 2021 was 223 times higher than the average of all vaccines combined for the past 30 years. This represented a 2500% increase in the absolute number of reports in the first year of the campaign when comparing historical values prior to 2021. Demographic data revealed that myocarditis occurred most in youths (50%) and males (69%). A total of 76% of cases resulted in emergency care and hospitalization. Of the total myocarditis reports, 92 individuals died (3%). Myocarditis was more likely after dose 2 ( p < 0.00001) and individuals less than 30 years of age were more likely than individuals older than 30 to acquire myocarditis ( p < 0.00001). Conclusion: COVID-19 vaccination is strongly associated with a serious adverse safety signal of myocarditis, particularly in children and young adults resulting in hospitalization and death. Further investigation into the underlying mechanisms of COVID-19 vaccine-induced myocarditis is imperative to create effective mitigation strategies and ensure the safety of COVID-19 vaccination programs across populations.

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Section: Discussionmentioning

confidence: 99%

Determinants of COVID-19 vaccine-induced myocarditis

Rose,

Hulscher,

McCullough

2024

Therapeutic Advances in Drug Safety

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Impact of Routine Rotavirus Vaccination in Germany

Marquis¹,

Koch

2020

Pediatric Infectious Disease Journal

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Background: Routine rotavirus (RV)-vaccination is recommended in Germany since August 2013. Five years later, we evaluated the recommendation by examining vaccine uptake and the impact on RV-gastroenteritis (RVGE) burden in all age groups and on intussusceptions in infants. Methods: We estimated RV-vaccine uptake in the 2014–2018 birth cohorts using statutory health insurance prescription data. For impact assessment, we analyzed RVGE-surveillance data of the German infectious diseases notification system. We compared age-specific RVGE-incidences of different severity between pre-vaccination (2005/06–2007/08) and routine vaccination period (2013/14–2017/18) calculating incidence rate ratios (IRR) using Poisson regression. To determine the effect on intussusception, we used hospital discharge data (2006–2017) and compared incidences between pre-vaccination and routine vaccination period using Poisson regression. Results: Vaccination coverage increased from 59% (2014) to 80% (2018). Incidences of RVGE-outpatient cases, RVGE-hospitalization and nosocomial RVGE among <5-year-olds decreased by 74% (IRR = 0.26; 95% CI: 0.26–0.27), 70% (IRR = 0.30; 95% CI: 0.30–0.31) and 70% (IRR = 0.30; 95% CI: 0.30–0.31), respectively. Incidence of RVGE-outpatient cases in age groups ineligible for RV-vaccination decreased by 38% (IRR 0.62; 95% CI: 0.61–0.63). Compared with the pre-vaccination period, incidence of intussusception in the first year of life decreased by 28% (IRR = 0.73; 95% CI: 0.68–0.79) while at age of the first vaccine-dose (7th–12th week of age) increase in incidence of intussusception was non-significant (IRR = 1.29; 95% CI: 0.93–1.78). Conclusions: Routine RV-vaccination is well accepted in Germany. Since implementation of routine RV-vaccination, RVGE significantly decreased in <5-year-olds and in non-vaccinated older age groups through herd protection. The decline of intussusceptions in the first life year suggests a potential vaccination-associated protection against gastrointestinal infections that might trigger intussusceptions. These encouraging results should be communicated to doctors and parents for further improvement of vaccine uptake and protection of more infants.

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Intussusception as a complication of rotavirus infection in children

Cited by 2 publications

References 38 publications

Determinants of COVID-19 vaccine-induced myocarditis

Determinants of COVID-19 vaccine-induced myocarditis

Impact of Routine Rotavirus Vaccination in Germany

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