Intubation Attempts Increase the Risk for Severe Intraventricular Hemorrhage in Preterm Infants—A Retrospective Cohort Study

Sauer, Charles W.; Kong, Juin Yee; Vaucher, Yvonne E.; Finer, Neil N.; Proudfoot, James; Boutin, Mallory A.; Leone, Tina A.

doi:10.1016/j.jpeds.2016.06.051

Cited by 95 publications

(67 citation statements)

References 27 publications

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“…This occurred even though the infants were breathing lower FiO 2 than in the prestudy group, and the level was even lower in poststudy group when SIM was also used. The lowest rate of IVH in the study group could be consistent with the studies that have drawn attention to the association between delivery room intubation and a higher risk of IVH development .…”

Section: Discussionsupporting

confidence: 89%

Oropharyngeal surfactant can improve initial stabilisation and reduce rescue intubation in infants born below 25 weeks of gestation

et al. 2017

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Section: Discussionsupporting

confidence: 89%

Oropharyngeal surfactant can improve initial stabilisation and reduce rescue intubation in infants born below 25 weeks of gestation

et al. 2017

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“…The narrow oropharyngeal cavity in the most preterm infants does not always allow the visualization of the vocal cords once the tube is in place. Emergency intubation of a preterm infant is stressful for most operators, and the skills to integrate multiples depth markers at that time might be lacking for less experienced practioners . Finally, the tube may be displaced during the removal of the laryngoscope or at time of taping.…”

Section: Discussionmentioning

confidence: 99%

Distances from vocal cords to mid‐trachea for optimizing endotracheal tubes depth markers according to gestational age

Rigo

Fayoux

2018

Pediatric Anesthesia

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“…Sauer et al [33], in a retrospective cohort study including infants with less than 1500 g of birth weight, found that increased intubation attempts in the delivery room were associated with increased incidence of severe IVH. In our study group, the need for resuscitation in the delivery room is evident as a risk factor for IVH, given that 46.5% of intubations in the delivery room occurred in the case group compared with only 26.7% in the control group.…”

Section: Discussionmentioning

confidence: 99%

Low-grade intraventricular hemorrhage and neurodevelopment at 24 months of age

Peixoto

Amaral

Resende

et al. 2018

Sci Med

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AIMS: To evaluate the impact of low-grade intraventricular hemorrhage on neurodevelopmental outcome in preterm infants at 24 months of age. METHODS: We conducted a retrospective case-control study of infants with gestational age less than 34 weeks, admitted to a Neonatal Intensive Care Unit between January/2006 and December/2015. Cases were defined as those with low-grade intraventricular hemorrhage (grades I or II), diagnosed by cranial ultrasonography. For each case, a control with the same gestational age but without intraventricular hemorrhage was selected. Follow-up examinations of neurodevelopment were performed at 24 months of age in cases and controls using the Griffiths Mental Development Scale. Cerebral palsy, neurodevelopmental delay (developmental quotient <2 side deviations below the mean), hearing impairment and/or blindness were considered as severe neurodevelopmental impairment. RESULTS: The study included 172 preterm infants: 86 cases and 86 controls. In the univariate analysis, a difference between the two groups was identified for the following clinical findings: antenatal corticosteroid complete cycle (57% in cases vs. 80% in controls; p=0.001; OR: 0.33, 95%CI 0.17-0.64); male gender (63% cases vs. 41% controls; p=0.004; OR: 2.45, 95%CI 1.3-4.5); outborn (26% cases vs. 9% controls; p=0.005; OR: 3.3 95%CI 1.4-8.0); Clinical Risk Index for Babies higher than 5 (24% in cases vs. 12% in controls; p=0.029; OR: 2.4 95%CI 1.1-5.6); intubation in the delivery room (47% cases vs. 27% controls; p=0.007; OR: 2.38 95%CI 1.3-4.5); and neonatal sepsis (34% in cases vs. 20% in controls; p=0.039; OR: 2.1 95%CI 1.03-4.1). After logistic regression, differences were only maintained for antenatal corticosteroid (p=0.005; OR 0.34, 95%CI 0.16-0.72) and male gender (p=0.002; OR 2.9, 95%CI 1.4-5.8). A severe neurodevelopmental deficit was present in three cases (3.5%) and one control (1.2%). No statistically significant differences in outcome were found between cases and controls. CONCLUSIONS: In this sample, preterm infants with low-grade intraventricular hemorrhage diagnosed by cranial ultrasonography had no difference in early neurodevelopmental outcome when compared with controls.KEYWORDS: cerebral intraventricular hemorrhage; preterm infant; neurodevelopmental disorders. RESUMOOBJETIVOS: Avaliar o impacto da hemorragia intraventricular de baixo grau no neurodesenvolvimento de lactentes prematuros aos 24 meses de idade. MÉTODOS: Foi conduzido um estudo de caso-controle retrospectivo em lactentes com idade gestacional inferior a 34 semanas, internados em uma Unidade de Terapia Intensiva Neonatal entre janeiro de 2006 e dezembro de 2015. Os casos foram definidos como aqueles com hemorragia intraventricular de baixo grau (graus I ou II), diagnosticada por ultrassonografia craniana. Para cada caso, foi selecionado um controle com a mesma idade gestacional, mas sem hemorragia intraventricular. A avaliação do neurodesenvolvimento foi realizada aos 24 meses de idade, em casos e controles, com a Escala de Desen...

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Intubation Attempts Increase the Risk for Severe Intraventricular Hemorrhage in Preterm Infants—A Retrospective Cohort Study

Cited by 95 publications

References 27 publications

Oropharyngeal surfactant can improve initial stabilisation and reduce rescue intubation in infants born below 25 weeks of gestation

Oropharyngeal surfactant can improve initial stabilisation and reduce rescue intubation in infants born below 25 weeks of gestation

Distances from vocal cords to mid‐trachea for optimizing endotracheal tubes depth markers according to gestational age

Low-grade intraventricular hemorrhage and neurodevelopment at 24 months of age

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