Introgression of mitochondrial DNA among Myodes voles: consequences for energetics?

Boratyński, Zbyszek; Alves, Paulo C.; Berto, Stefano; Koskela, Esa; Mappes, Johanna; Melo‐Ferreira, José

doi:10.1186/1471-2148-11-355

Cited by 54 publications

(58 citation statements)

References 64 publications

(77 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surprisingly, of the few studies to assay potential functional differences between mitochondrial types that could influence introgression, most have found only limited support (e.g. Salvelinus by Blier et al 2006; Myodes by Boratynski et al 2011). For example, testing for differences in metabolic rate between sympatric individuals of the bank vole (Myodes glareolus), some with northern red-backed vole (M. rutilus) mitochondria, Boratynski et al (2011) found that mitochondrial type explained very little variation in basal metabolic rate.…”

Section: Untangling Processes Driving Discordance From Biogeographic mentioning

confidence: 99%

“…Salvelinus by Blier et al 2006; Myodes by Boratynski et al 2011). For example, testing for differences in metabolic rate between sympatric individuals of the bank vole (Myodes glareolus), some with northern red-backed vole (M. rutilus) mitochondria, Boratynski et al (2011) found that mitochondrial type explained very little variation in basal metabolic rate. Blier et al (2006) also found little evidence to suggest that functional differences in enzyme activity could explain the introgression of Arctic charr (Salvelinus alpinus) mtDNA into brook charr (S. fontinalis).…”

Section: Untangling Processes Driving Discordance From Biogeographic mentioning

confidence: 99%

See 1 more Smart Citation

The biogeography of mitochondrial and nuclear discordance in animals

2012

View full text Add to dashboard Cite

Combining nuclear (nuDNA) and mitochondrial DNA (mtDNA) markers has improved the power of molecular data to test phylogenetic and phylogeographic hypotheses and has highlighted the limitations of studies using only mtDNA markers. In fact, in the past decade, many conflicting geographic patterns between mitochondrial and nuclear genetic markers have been identified (i.e. mito-nuclear discordance). Our goals in this synthesis are to: (i) review known cases of mito-nuclear discordance in animal systems, (ii) to summarize the biogeographic patterns in each instance and (iii) to identify common drivers of discordance in various groups. In total, we identified 126 cases in animal systems with strong evidence of discordance between the biogeographic patterns obtained from mitochondrial DNA and those observed in the nuclear genome. In most cases, these patterns are attributed to adaptive introgression of mtDNA, demographic disparities and sex-biased asymmetries, with some studies also implicating hybrid zone movement, human introductions and Wolbachia infection in insects. We also discuss situations where divergent mtDNA clades seem to have arisen in the absence of geographic isolation. For those cases where foreign mtDNA haplotypes are found deep within the range of a second taxon, data suggest that those mtDNA haplotypes are more likely to be at a high frequency and are commonly driven by sex-biased asymmetries and ⁄ or adaptive introgression. In addition, we discuss the problems with inferring the processes causing discordance from biogeographic patterns that are common in many studies. In many cases, authors presented more than one explanation for discordant patterns in a given system, which indicates that likely more data are required. Ideally, to resolve this issue, we see important future work shifting focus from documenting the prevalence of mito-nuclear discordance towards testing hypotheses regarding the drivers of discordance. Indeed, there is great potential for certain cases of mitochondrial introgression to become important natural systems within which to test the effect of different mitochondrial genotypes on whole-animal phenotypes.

show abstract

Section: Untangling Processes Driving Discordance From Biogeographic mentioning

confidence: 99%

Section: Untangling Processes Driving Discordance From Biogeographic mentioning

confidence: 99%

The biogeography of mitochondrial and nuclear discordance in animals

2012

View full text Add to dashboard Cite

show abstract

“…In this study we used two closely related but ecologically distinct species of Myodes voles between which introgression of the mitochondrial genome has been described (Tegelström, 1987;Boratyń ski et al, 2011) in order to examine signs of evolution of mtDNA under natural selection.…”

Section: Discussionmentioning

confidence: 99%

“…For example, studies on the Eurasian bank vole Myodes (or Clethrionomys) glareolus have shown that its northeastern, and some eastern, populations harbour an mtDNA lineage that introgressed from its neighbour, Myodes rutilus, that has even become fixed in some populations (Tegelström, 1987;Deffontaine et al, 2005;Boratyń ski et al, 2011). This observation led to the hypothesis that colonization of northeastern Europe and western Asia by M. glareolus was facilitated by the introgression (before or during colonization of currently occupied regions), through hybridization, of physiological mechanisms that allowed it to inhabit more severe habitats (Boratyń ski et al, 2011;Šíchová et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Molecular and ecological signs of mitochondrial adaptation: consequences for introgression?

et al. 2014

View full text Add to dashboard Cite

The evolution of the mitochondrial genome and its potential adaptive impact still generates vital debates. Even if mitochondria have a crucial functional role, as they are the main cellular energy suppliers, mitochondrial DNA (mtDNA) introgression is common in nature, introducing variation in populations upon which selection may act. Here we evaluated whether the evolution of mtDNA in a rodent species affected by mtDNA introgression is explained by neutral expectations alone. Variation in one mitochondrial and six nuclear markers in Myodes glareolus voles was examined, including populations that show mtDNA introgression from its close relative, Myodes rutilus. In addition, we modelled protein structures of the mtDNA marker (cytochrome b) and estimated the environmental envelopes of mitotypes. We found that massive mtDNA introgression occurred without any trace of introgression in the analysed nuclear genes. The results show that the native glareolus mtDNA evolved under past positive selection, suggesting that mtDNA in this system has selective relevance. The environmental models indicate that the rutilus mitotype inhabits colder and drier habitats than the glareolus one that can result from local adaptation or from the geographic context of introgression. Finally, homology models of the cytochrome b protein revealed a substitution in rutilus mtDNA in the vicinity of the catalytic fraction, suggesting that differences between mitotypes may result in functional changes. These results suggest that the evolution of mtDNA in Myodes may have functional, ecological and adaptive significance. This work opens perspective onto future experimental tests of the role of natural selection in mtDNA introgression in this system.

show abstract

“…While most studies involve cybrids created in vitro (Kenyon and Moraes, 1997;McKenzie et al, 2003McKenzie et al, , 2004Cannon et al, 2011) or obtained by directed backcrossing (Sackton et al, 2003;Ellison and Burton, 2006;Harrison and Burton, 2006;Pichaud et al, 2012), some cybrid organisms spontaneously appear in natural environments (Boratynski et al, 2011;Angers et al, 2012;Toews and Brelsford, 2012). Unlike artificially obtained cybrids, natural cybrids must deal with their foreign mitochondria to survive and reproduce in their environment.…”

Section: Introductionmentioning

confidence: 97%