Introgression of Brown Norway Chromosome 13 Improves Visual Spatial Memory in the Dahl S Rat

Kerr, Abigail L.; Hensel, Megan L.; Peterson, Todd C.; Villatoro, Lee O.; Nye, Steven H.; Swain, Rodney A.

doi:10.1007/s10519-009-9296-6

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…Learning and memory of the new platform location was examined to assess the animals' abilities to reacquire the learned strategy when the platform was moved to a new location (reversal). 29 Rats in the nanoZnO-treated group spent more time finding the hidden platform. It is worth noting that nano-ZnO-treated rats spent less time in the new quadrant (NE) and spent more time in the original quadrant (SW) than the control group in temporal distribution.…”

Section: Effects Of Nano-zno On Reacquisition Phase In Mwmmentioning

confidence: 92%

Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats

Han¹,

Tian²,

Zhang³

et al. 2011

IJN

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This study focused on the effects of zinc oxide nanoparticles (nano-ZnO) on spatial learning and memory and synaptic plasticity in the hippocampus of young rats, and tried to interpret the underlying mechanism. Rats were randomly divided into four groups. Nano-ZnO and phosphate-buffered saline were administered in 4-week-old rats for 8 weeks. Subsequently, performance in Morris water maze (MWM) was determined, and then long-term potentiation (LTP) and depotentiation were measured in the perforant pathway to dentate gyrus (DG) in anesthetized rats. The data showed that, (1) in MWM, the escape latency was prolonged in the nano-ZnO group and, (2) LTP was significantly enhanced in the nano-ZnO group, while depotentiation was barely influenced in the DG region of the nano-ZnO group. This bidirectional effect on long-term synaptic plasticity broke the balance between stability and flexibility of cognition. The spatial learning and memory ability was attenuated by the alteration of synaptic plasticity in nano-ZnO-treated rats.

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Section: Effects Of Nano-zno On Reacquisition Phase In Mwmmentioning

confidence: 92%

Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats

Han¹,

Tian²,

Zhang³

et al. 2011

IJN

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show abstract

“…25,26 The platform was submerged in the southwest quadrant, opposite to its initial location in the reference memory task. Each rat was given four trials per day, starting from one of four randomly selected release points (intertrial interval was 15 min).…”

Section: Mwm: Reversal Learning Taskmentioning

confidence: 99%

A Comparison of the Effects of Nicotinamide and Progesterone on Functional Recovery of Cognitive Behavior following Cortical Contusion Injury in the Rat

Peterson

Anderson

Kantor

et al. 2012

Journal of Neurotrauma

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The primary goal of this study was to compare clinically relevant doses of progesterone and nicotinamide within the same injury model. Progesterone has been shown to reduce edema and inflammation and improve functional outcomes following brain injury. Nicotinamide has also been shown to be an effective neuroprotective agent in a variety of neurological injury models. In the current study, nicotinamide was administered beginning 4 h post-cortical contusion injury (CCI) with a loading dose (75 mg/kg, i.p.) combined with continuous infusion (12 mg/h/kg, s.c.) for 72 h post-injury. Progesterone was administered beginning 4 h post-CCI at a dose of 10 or 20 mg/kg, i.p. every 12 h for 72 h. This resulted in the following groups: Injured-nicotinamide treated, Injured-progesterone-10 treated, Injured-progesterone-20 treated, Injured-vehicle treated, and Sham. Functional recovery was assessed with two spatial memory tasks in the Morris water maze (MWM) the acquisition of a reference memory task and a reversal learning task. Neuropathological assessments were conducted in the cortex and hippocampus. It was found that both progesterone (10 mg/kg) and nicotinamide improved reference memory acquisition and reversal learning in the MWM compared with vehicle treatment. The lower dose of progesterone and nicotinamide also reduced tissue loss in the injured cortex and ipsilateral hippocampus compared with vehicle. The beneficial effects of progesterone appear to be dose dependent with the lower 10 mg/kg dose producing significant effects that were not observed at the higher dose. Direct comparison between nicotinamide and low dose progesterone appears to suggest that both are equally effective. The general findings of this study suggest that both nicotinamide and progesterone produce significant improvements in recovery of function following CCI.

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Introgression of Brown Norway Chromosome 13 Improves Visual Spatial Memory in the Dahl S Rat

Cited by 2 publications

References 35 publications

Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats

Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats

A Comparison of the Effects of Nicotinamide and Progesterone on Functional Recovery of Cognitive Behavior following Cortical Contusion Injury in the Rat

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