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In man's nature there are several periods which they call ages; infant, child, adolescent. youth, man, elderly man, old man; an infant is up to seven years, the cut,ting of teeth; a boy up to the beginning of puberty, fourteen years; an adolescent, up to the appearance of down on the chin at 21 years; youth, to the end of development. at 28 years; man, up to 49 years; elderlv, up to 56 years, and after this, an old man." Hippocrates By Hippocrates' standards, vitamin E (tu-t.ocophero1 J has achieved "old man" status since it. was originally discovered nearly seven decades ago (1 ). However, in the field of human clinical nutrition, vitamin E is an infant who has only begun "cutting its t.eeth" over the past decade; previously it was considered by most as a "vitamin looking for a disease'' ( 2 ) . Originallv described as a factor that prevented fetal resorption in the laboratory rat (l), the nutritional role of vitamin E expanded when Evans and Burr (3) reported in 1928 a paralysis in t,he suckling offspring of vitamin E-deficient mother rats. This new neurological role for vit,amin E was further substantiated by reports of "nutritional encephalomalacia" in the chick (4) and "nutrit,ional muscular dystrophy" in guinea pigs and rats (5) fed vitamin E-deficient diets. In 1936, Evans et, al. (6) isolated from wheat. germ an alcohol having the biological activity of vitamin E and proposed the term "tocopherol," derived from theGreek "tokos" (offspring) and "pherein" (to bear). Finally, in the 1950's, the antioxidant properties of vitamin E became evident (7,8), and it,s interrelationship t.o the trace mineral, selenium, a component, of the antioxidant enzyme glutathione peroxidase (9, lo), also was discovered. Thus, by 1960 it was well established that vitamin E functioned as a lipid-soluble antioxidant in animals and was essential for the development and maintenance of reproduction and neurological function. Although vitamin E is currently being studied in relation to a number of human diseases and metabolic processes, one area of recent interest and investigation in human nutrition has been the identification of vitamin E malabsorption and deficiency during pathological disorders causing nialabsorption of dietary fat. To this end, in this issue of Hepatology, Muiioz and coworkers ( 11 ) have carefully examined intestinal absorption of vitamin E in pat.ients with primary biliary cirrhosis (PHC) and vitamin E
In man's nature there are several periods which they call ages; infant, child, adolescent. youth, man, elderly man, old man; an infant is up to seven years, the cut,ting of teeth; a boy up to the beginning of puberty, fourteen years; an adolescent, up to the appearance of down on the chin at 21 years; youth, to the end of development. at 28 years; man, up to 49 years; elderlv, up to 56 years, and after this, an old man." Hippocrates By Hippocrates' standards, vitamin E (tu-t.ocophero1 J has achieved "old man" status since it. was originally discovered nearly seven decades ago (1 ). However, in the field of human clinical nutrition, vitamin E is an infant who has only begun "cutting its t.eeth" over the past decade; previously it was considered by most as a "vitamin looking for a disease'' ( 2 ) . Originallv described as a factor that prevented fetal resorption in the laboratory rat (l), the nutritional role of vitamin E expanded when Evans and Burr (3) reported in 1928 a paralysis in t,he suckling offspring of vitamin E-deficient mother rats. This new neurological role for vit,amin E was further substantiated by reports of "nutritional encephalomalacia" in the chick (4) and "nutrit,ional muscular dystrophy" in guinea pigs and rats (5) fed vitamin E-deficient diets. In 1936, Evans et, al. (6) isolated from wheat. germ an alcohol having the biological activity of vitamin E and proposed the term "tocopherol," derived from theGreek "tokos" (offspring) and "pherein" (to bear). Finally, in the 1950's, the antioxidant properties of vitamin E became evident (7,8), and it,s interrelationship t.o the trace mineral, selenium, a component, of the antioxidant enzyme glutathione peroxidase (9, lo), also was discovered. Thus, by 1960 it was well established that vitamin E functioned as a lipid-soluble antioxidant in animals and was essential for the development and maintenance of reproduction and neurological function. Although vitamin E is currently being studied in relation to a number of human diseases and metabolic processes, one area of recent interest and investigation in human nutrition has been the identification of vitamin E malabsorption and deficiency during pathological disorders causing nialabsorption of dietary fat. To this end, in this issue of Hepatology, Muiioz and coworkers ( 11 ) have carefully examined intestinal absorption of vitamin E in pat.ients with primary biliary cirrhosis (PHC) and vitamin E
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