Introductory Chapter: Update on Mesenchymal and Induced Pluripotent Stem Cells

Al-Anazi, Khalid Ahmed

doi:10.5772/intechopen.90236

Cited by 2 publications

(1 citation statement)

References 69 publications

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“…Based on their origin and potency, stem cells are classified into either embryonic and adult stem cells or unipotent, oligopotent, totipotent, multipotent, and pluripotent stem cells [45,46,48,49]. Mesenchymal Stem Cells (MSCs) are heterogenous adult multipotent stromal cells that can be isolated from various sources including: BM, Peripheral Blood (PB), Umbilical Cord Blood (UCB), and Adipose Tissue (AT) [50,51]. They have certain immunomodulatory, immunosuppressive, and antimicrobial properties that enable them to have several clinical applications including: their role in transplantation of Hematopoietic Stem Cells (HSCs) as well as regenerative medicine and treatment of autoimmune disorders [50,51].…”

Section: Stem Cell and Their Role In The Therapy Of Sscmentioning

confidence: 99%

Stem Cell Therapies in Systemic Sclerosis: An Updated Review

Al-Ansari¹,

Al-Anazi²

2020

JRMBR

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Section: Stem Cell and Their Role In The Therapy Of Sscmentioning

confidence: 99%

Stem Cell Therapies in Systemic Sclerosis: An Updated Review

Al-Ansari¹,

Al-Anazi²

2020

JRMBR

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MSCs vs. iPSCs: Potential in therapeutic applications

Thanaskody¹,

Jusop²,

Tye³

et al. 2022

Front. Cell Dev. Biol.

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Over the past 2 decades, mesenchymal stem cells (MSCs) have attracted a lot of interest as a unique therapeutic approach for a variety of diseases. MSCs are capable of self-renewal and multilineage differentiation capacity, immunomodulatory, and anti-inflammatory properties allowing it to play a role in regenerative medicine. Furthermore, MSCs are low in tumorigenicity and immune privileged, which permits the use of allogeneic MSCs for therapies that eliminate the need to collect MSCs directly from patients. Induced pluripotent stem cells (iPSCs) can be generated from adult cells through gene reprogramming with ectopic expression of specific pluripotency factors. Advancement in iPS technology avoids the destruction of embryos to make pluripotent cells, making it free of ethical concerns. iPSCs can self-renew and develop into a plethora of specialized cells making it a useful resource for regenerative medicine as they may be created from any human source. MSCs have also been used to treat individuals infected with the SARS-CoV-2 virus. MSCs have undergone more clinical trials than iPSCs due to high tumorigenicity, which can trigger oncogenic transformation. In this review, we discussed the overview of mesenchymal stem cells and induced pluripotent stem cells. We briefly present therapeutic approaches and COVID-19-related diseases using MSCs and iPSCs.

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Introductory Chapter: Update on Mesenchymal and Induced Pluripotent Stem Cells

Cited by 2 publications

References 69 publications

Stem Cell Therapies in Systemic Sclerosis: An Updated Review

Stem Cell Therapies in Systemic Sclerosis: An Updated Review

MSCs vs. iPSCs: Potential in therapeutic applications

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