Introductory Chapter: Phosphorus - Nature’s Versatile Pentavalent and Tetrahedral Covalent Building Block and Agent for Energy, Disease and Health

Lee, Won Chul; Abdillah, Ariq; Palma, Jaymee; Churchill, David G.

doi:10.5772/intechopen.93009

Cited by 3 publications

(4 citation statements)

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“…All living creatures, irrespective of being either the simplest monocellular forms of algae or the most complex mammals, share the same fundamental constituents and the same few molecular bricks that combine with each other to form an infinite variety of complex macromolecular systems: amino acids for proteins, lipids for the lipidic membranes of the cells, sugars, and nucleobases for DNA and RNA. These macromolecules are mostly formed by few macroelements (SONCH), to whom P deserves to be added because, although it represents only 1% w/w in terms of abundance with respect to the other macroelements, it is a key element in the form of phosphate (PO 4 3– ) devoted to activating and deactivating the specific function of a protein, forming the cell membranes (phospholipids), connecting the nucleobases with each other, thus forming, together with ribose molecules, the outermost part of the double helix, 1 forming nucleotides essential for the bioenergetic of the cell. …”

Section: Introductionmentioning

confidence: 99%

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Computational Study on the Water Corrosion Process at Schreibersite (Fe₂NiP) Surfaces: from Phosphide to Phosphates

Pantaleone,

Corno,

Rimola

et al. 2023

ACS Earth Space Chem.

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Phosphorus (P) is a fundamental element for whatever form of life, in the same way as the other biogenic macroelements (SONCH). The prebiotic origin of P is still a matter of debate, as the phosphates present on earth are trapped in almost insoluble solid matrixes (apatites) and, therefore, hardly available for inclusion in living systems in the prebiotic era. The most accepted theories regard a possible exogenous origin during the Archean Era, through the meteoritic bombardment, when tons of reactive P in the form of phosphide ((Fe,Ni)3P, schreibersite mineral) reached the primordial earth, reacting with water and providing oxygenated phosphorus compounds (including phosphates). In the last 20 years, laboratory experiments demonstrated that the corrosion process of schreibersite by water indeed leads to reactive phosphates that, in turn, react with other biological building blocks (nucleosides and simple sugars) to form more complex molecules (nucleotides and complex sugars). In the present paper, we study the water corrosion of different crystalline surfaces of schreibersite by means of periodic DFT (density functional theory) simulations. Our results show that water adsorbs molecularly on the most stable (110) surface but dissociates on the less stable (001) one, giving rise to further reactivity. Indeed, subsequent water adsorptions, up to the water monolayer coverage, show that, on the (001) surface, iron and nickel atoms are the first species undergoing the corrosion process and, in a second stage, the phosphorus atoms also get involved. When adsorbing up to three and four water molecules per unit cell, the most stable structures found are the phosphite and phosphate forms of phosphorus, respectively. Simulation of the vibrational spectra of the considered reaction products revealed that the experimental band at 2423 cm–1 attributed to the P–H stretching frequency is indeed predicted for a phosphite moiety attached to the schreibersite (001) surface upon chemisorption of up to three water molecules.

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Section: Introductionmentioning

confidence: 99%

“…connecting the nucleobases with each other, thus forming, together with ribose molecules, the outermost part of the double helix, 1 …”

Section: Introductionmentioning

confidence: 99%

Computational Study on the Water Corrosion Process at Schreibersite (Fe₂NiP) Surfaces: from Phosphide to Phosphates

Pantaleone,

Corno,

Rimola

et al. 2023

ACS Earth Space Chem.

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“…They provide stable ligation necessary for fixing information in RNA and DNA, contribute to cellular structure in phospholipids, serve as the main source of biochemical energy (e.g., ATP, phosphoenolpyruvate, creatinephosphate), and are present in a large number of metabolites. Phosphates retain a central place in biological systems, which allows us to conclude that they played an important role in the emergence of life on Earth [1][2][3][4]. In recent years, a large number of natural phosphorus compounds have been isolated from living organisms and significant advances have been made in understanding the effects of phosphates on prebiotic chemistry.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, a large number of natural phosphorus compounds have been isolated from living organisms and significant advances have been made in understanding the effects of phosphates on prebiotic chemistry. A number of natural phosphorus compounds have practical applications (Figure 1) [2].…”

Section: Introductionmentioning

confidence: 99%

Phosphorus Compounds of Natural Origin: Prebiotic, Stereochemistry, Application

Kolodiazhnyi

2021

Symmetry

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Organophosphorus compounds play a vital role as nucleic acids, nucleotide coenzymes, metabolic intermediates and are involved in many biochemical processes. They are part of DNA, RNA, ATP and a number of important biological elements of living organisms. Synthetic compounds of this class have found practical application as agrochemicals, pharmaceuticals, bioregulators, and others. In recent years, a large number of phosphorus compounds containing P-O, P-N, P-C bonds have been isolated from natural sources. Many of them have shown interesting biological properties and have become the objects of intensive scientific research. Most of these compounds contain asymmetric centers, the absolute configurations of which have a significant effect on the biological properties of the products of their transformations. This area of research on natural phosphorus compounds is still little-studied, that prompted us to analyze and discuss it in our review. Moreover natural organophosphorus compounds represent interesting models for the development of new biologically active compounds, and a number of promising drugs and agrochemicals have already been obtained on their basis. The review also discusses the history of the development of ideas about the role of organophosphorus compounds and stereochemistry in the origin of life on Earth, starting from the prebiotic period, that allows us in a new way to consider this most important problem of fundamental science.

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Catalytic Asymmetric Synthesis of C-Chiral Phosphonates

Kolodiazhna

Kolodiazhnyi

2022

Symmetry

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The current review is devoted to the achievements in the development of methods for the catalytic asymmetric synthesis of phosphonates containing a chiral center in the side chain. C-chiral phosphonates are widely represented among natural compounds with various biological activities as insecticides, herbicides, antibiotics, and bioregulators. Synthetic representatives of this class have found practical application as biologically active compounds. The review summarizes methods of asymmetric metal complex catalysis and organocatalysis as applied to such reactions as phospha-aldol reaction, two-component and three-component phospha-Mannich reaction, phospha-Michael reaction, as well as hydrogenation of unsaturated phosphonates and phosphine oxides, ketophosphonates, and iminophosphonates. Methods for the asymmetric hydride reduction of C=X phosphonates (X=O, S, NR) are also discussed in detail. The review presents updated literature reports, as well as original research by the author.

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Introductory Chapter: Phosphorus - Nature’s Versatile Pentavalent and Tetrahedral Covalent Building Block and Agent for Energy, Disease and Health

Cited by 3 publications

References 50 publications

Computational Study on the Water Corrosion Process at Schreibersite (Fe₂NiP) Surfaces: from Phosphide to Phosphates

Computational Study on the Water Corrosion Process at Schreibersite (Fe₂NiP) Surfaces: from Phosphide to Phosphates

Phosphorus Compounds of Natural Origin: Prebiotic, Stereochemistry, Application

Catalytic Asymmetric Synthesis of C-Chiral Phosphonates

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Introductory Chapter: Phosphorus - Nature’s Versatile Pentavalent and Tetrahedral Covalent Building Block and Agent for Energy, Disease and Health

Cited by 3 publications

References 50 publications

Computational Study on the Water Corrosion Process at Schreibersite (Fe2NiP) Surfaces: from Phosphide to Phosphates

Computational Study on the Water Corrosion Process at Schreibersite (Fe2NiP) Surfaces: from Phosphide to Phosphates

Phosphorus Compounds of Natural Origin: Prebiotic, Stereochemistry, Application

Catalytic Asymmetric Synthesis of C-Chiral Phosphonates

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Computational Study on the Water Corrosion Process at Schreibersite (Fe₂NiP) Surfaces: from Phosphide to Phosphates

Computational Study on the Water Corrosion Process at Schreibersite (Fe₂NiP) Surfaces: from Phosphide to Phosphates