Introductory Chapter: Insight into the OMICS Technologies and Molecular Medicine

Nalbantoglu, Sinem; Karadağ, Abdullah

doi:10.5772/intechopen.86450

Cited by 8 publications

(5 citation statements)

References 50 publications

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“…The term ‘omic’ derives from the suffix –ome, which means ‘whole’, and is added to terms like gene, transcript, and protein to create names that encompass the entire set of biological molecules in a system, such as genome, transcriptome, and proteome. The addition of ‘omics’ to the terms (genomics, transcriptomics, and proteomics) refers to the comprehensive assessment of these molecules in a non-targeted and unbiased manner ( Nalbantoglu and Karadag, 2019 ). An overview of omics approaches used to study STB biology is provided in Figure 2 .…”

Section: Omics: An Overviewmentioning

confidence: 99%

Omics Approaches to Study Formation and Function of Human Placental Syncytiotrophoblast

Jaremek

Jeyarajah

Bhattad

et al. 2021

Front. Cell Dev. Biol.

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Proper development of the placenta is vital for pregnancy success. The placenta regulates exchange of nutrients and gases between maternal and fetal blood and produces hormones essential to maintain pregnancy. The placental cell lineage primarily responsible for performing these functions is a multinucleated entity called syncytiotrophoblast. Syncytiotrophoblast is continuously replenished throughout pregnancy by fusion of underlying progenitor cells called cytotrophoblasts. Dysregulated syncytiotrophoblast formation disrupts the integrity of the placental exchange surface, which can be detrimental to maternal and fetal health. Moreover, various factors produced by syncytiotrophoblast enter into maternal circulation, where they profoundly impact maternal physiology and are promising diagnostic indicators of pregnancy health. Despite the multifunctional importance of syncytiotrophoblast for pregnancy success, there is still much to learn about how its formation is regulated in normal and diseased states. ‘Omics’ approaches are gaining traction in many fields to provide a more holistic perspective of cell, tissue, and organ function. Herein, we review human syncytiotrophoblast development and current model systems used for its study, discuss how ‘omics’ strategies have been used to provide multidimensional insights into its formation and function, and highlight limitations of current platforms as well as consider future avenues for exploration.

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Section: Omics: An Overviewmentioning

confidence: 99%

Omics Approaches to Study Formation and Function of Human Placental Syncytiotrophoblast

Jaremek

Jeyarajah

Bhattad

et al. 2021

Front. Cell Dev. Biol.

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“…Biorepositories play a vital role in modern biomedical research by overseeing the acquisition, preservation, handling, and organization of biological specimens and clinical information derived from human participants [5,6]. They also leverage advanced technologies such as omics data, bioinformatics, AI, and systems biology to enhance their value, ultimately contributing to the expedited understanding of diseases, the advancement of treatments, and the support of precision medicine initiatives, particularly as we approach the era of smart healthcare systems [6][7][8][9][10]. The integration of comprehensive biological pro les is crucial for revealing disease-related patterns, mechanisms, and biomarkers, supporting targeted screening, diagnostics, therapeutics, and early risk evaluation [11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

LUNGBANK: A Novel Biorepository Strategy Tailored for Comprehensive Multi-Omics Analysis and P-Medicine Applications in Lung Cancer

Ceker,

Baysungur,

Evman

et al. 2024

Preprint

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Background: In support of Project LUNGMARK, LUNGBANK was established as a pioneering biorepository dedicated to lung cancer. Designed for streamlined biospecimen handling, it employs high-volume technologies to secure high-quality samples. Fortified with robust data management, LUNGBANK efficiently integrates diverse datasets. This strategic infrastructure positions LUNGBANK as more than a biospecimen repository; it operates as a sophisticated platform for advanced lung cancer research, amplifying the potential for meaningful discoveries. Methods: In support of Project LUNGMARK, the establishment of LUNGBANK, a pioneering biorepository system dedicated to lung cancer, was undertaken. LUNGBANK is intricately designed to streamline the collection, transfer, storage, and processing of biospecimens, employing high-volume technologies to ensure the acquisition of high-quality biological specimens. The system is fortified with robust data management protocols, facilitating efficient integration of diverse datasets. This strategic infrastructure ensures that LUNGBANK not only serves as a repository of biospecimens but also operates as a sophisticated platform for advanced lung cancer research, enhancing the potential for meaningful discoveries in the field. Results: LUNGBANK, serving as a groundbreaking biorepository system, plays a pivotal role in furnishing a rich collection of biospecimens essential for unraveling the molecules and mechanisms linked to lung cancer. Rigorous standard operating procedures guided the meticulous collection of biospecimens, subjecting them to stringent quality control measures before inclusion in the study. Moreover, LUNGBANK has proven valuable in the establishment of patient-derived systems. The incorporation of cutting-edge technologies guarantees the acquisition of top-tier data, thereby amplifying the likelihood of substantial breakthroughs in both contemporary translational research and traditional histological evaluations. Conclusion: The establishment of LUNGBANK marks a significant stride towards addressing the pressing need for effective diagnostic and therapeutic systems in lung cancer research. By facilitating the collection and analysis of high-quality biospecimens, LUNGBANK serves as a valuable resource for unraveling the molecular intricacies of lung cancer initiation and progression. This comprehensive system not only supports Project LUNGMARK but also contributes to the broader landscape of personalized medicine, tailoring interventions to the specific needs of lung cancer patients.

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“…Biorepositories play a vital role in modern biomedical research by overseeing the acquisition, preservation, handling, and organization of biological specimens and clinical information derived from human participants ( Day and Stacey, 2008 ; Kinkorová and Topolčan, 2020 ). They also leverage advanced technologies such as omics data, bioinformatics, artificial intelligence, and systems biology to enhance their value, ultimately contributing to the expedited understanding of diseases, the advancement of treatments, and the support of precision medicine initiatives, particularly as we approach the era of smart healthcare systems ( Han et al, 2014 ; Carey et al, 2016 ; Kinkorová, 2016 ; Nalbantoglu and Karadag, 2019 ; Kinkorová and Topolčan, 2020 ). The integration of comprehensive biological profiles is crucial for revealing disease-related patterns, mechanisms, and biomarkers, supporting targeted screening, diagnostics, therapeutics, and early risk evaluation ( Bayat 2002 ; Horgan and Kenny, 2011 ; Goossens et al, 2015 ; Coppola et al, 2019 ; Biswas and Chakrabarti, 2020 ; Bhardwaj et al, 2022 ; Poetsch and Li, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

LUNGBANK: A Novel Biorepository Strategy Tailored for Comprehensive Multi-Omics Analysis and P-Medicine Applications in Lung Cancer

DEMİRCAN ÇEKER,

BAYSUNGUR,

EVMAN

et al. 2024

Turkish Journal of Biology

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Background/aim LUNGBANK was established as part of Project LUNGMARK, pioneering a biorepository dedicated exclusively to lung cancer research. It employs cutting-edge technologies to streamline the handling of biospecimens, ensuring the acquisition of high-quality samples. This infrastructure is fortified with robust data management capabilities, enabling seamless integration of diverse datasets. LUNGBANK functions not merely as a repository but as a sophisticated platform crucial for advancing lung cancer research, poised to facilitate significant discoveries. Materials and methods LUNGBANK was meticulously designed to optimize every stage of biospecimen handling, from collection and storage to processing. Rigorous standard operating procedures and stringent quality control measures guarantee the integrity of collected biospecimens. Advanced data management protocols facilitate the efficient integration and analysis of various datasets, enhancing the depth and breadth of research possibilities in lung cancer. Results LUNGBANK has amassed a comprehensive collection of biospecimens essential for unraveling the intricate molecular mechanisms of lung cancer. The integration of state-of-the-art technologies ensures the acquisition of top-tier data, fostering breakthroughs in translational and histological research. Moreover, the establishment of patient-derived systems by LUNGBANK underscores its pivotal role in personalized medicine approaches. Conclusion The establishment of LUNGBANK marks a significant milestone in addressing the critical challenges of lung cancer research. By providing researchers with high-quality biospecimens and advanced research tools, LUNGBANK not only supports Project LUNGMARK’s objectives but also contributes extensively to the broader landscape of personalized medicine. It promises to enhance our understanding of lung cancer initiation, progression, and therapeutic interventions tailored to individual patient needs, thereby advancing the field towards more effective diagnostic and therapeutic strategies.

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Introductory Chapter: Insight into the OMICS Technologies and Molecular Medicine

Cited by 8 publications

References 50 publications

Omics Approaches to Study Formation and Function of Human Placental Syncytiotrophoblast

Omics Approaches to Study Formation and Function of Human Placental Syncytiotrophoblast

LUNGBANK: A Novel Biorepository Strategy Tailored for Comprehensive Multi-Omics Analysis and P-Medicine Applications in Lung Cancer

LUNGBANK: A Novel Biorepository Strategy Tailored for Comprehensive Multi-Omics Analysis and P-Medicine Applications in Lung Cancer

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