Introduction - virally vectored immunocontraception in Australia

Tyndale-Biscoe, Hugh; Hinds, Lyn A.

doi:10.1071/wrv34n7_in

Cited by 13 publications

(10 citation statements)

References 31 publications

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“…Criticism of this approach raised concerns regarding its irreversibility, the difficulty of controlling the vectors once released, possible mutations of the vectors that could affect non-target species and possible development of population resistance to these vectors (e.g. Barlow 2000;Tyndale-Biscoe and Hinds 2007;Williams 2007). For these reasons, none of these systems has been approved for field studies.…”

Section: Delivery Methodsmentioning

confidence: 99%

Fertility control to mitigate human–wildlife conflicts: a review

2014

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Abstract. As human populations grow, conflicts with wildlife increase. Concurrently, concerns about the welfare, safety and environmental impacts of conventional lethal methods of wildlife management restrict the options available for conflict mitigation. In parallel, there is increasing interest in using fertility control to manage wildlife. The present review aimed at analysing trends in research on fertility control for wildlife, illustrating developments in fertility-control technologies and delivery methods of fertility-control agents, summarising the conclusions of empirical and theoretical studies of fertility control applied at the population level and offering criteria to guide decisions regarding the suitability of fertility control to mitigate human-wildlife conflicts. The review highlighted a growing interest in fertility control for wildlife, underpinned by increasing numbers of scientific studies. Most current practical applications of fertility control for wild mammals use injectable single-dose immunocontraceptive vaccines mainly aimed at sterilising females, although many of these vaccines are not yet commercially available. One oral avian contraceptive, nicarbazin, is commercially available in some countries. Potential new methods of remote contraceptive delivery include bacterial ghosts, virus-like particles and genetically modified transmissible and non-transmissible organisms, although none of these have yet progressed to field testing. In parallel, new species-specific delivery systems have been developed. The results of population-level studies of fertility control indicated that this approach may increase survival and affect social and spatial behaviour of treated animals, although the effects are species-and context-specific. The present studies suggested that a substantial initial effort is generally required to reduce population growth if fertility control is the sole wildlife management method. However, several empirical and field studies have demonstrated that fertility control, particularly of isolated populations, can be successfully used to limit population growth and reduce human-wildlife conflicts. In parallel, there is growing recognition of the possible synergy between fertility control and disease vaccination to optimise the maintenance of herd immunity in the management of wildlife diseases. The review provides a decision tree that can be used to determine whether fertility control should be employed to resolve specific human-wildlife conflicts. These criteria encompass public consultation, considerations about animal welfare and feasibility, evaluation of population responses, costs and sustainability.

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Section: Delivery Methodsmentioning

confidence: 99%

Fertility control to mitigate human–wildlife conflicts: a review

2014

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“…Despite concerted efforts over 10-15 years for mice, rabbits and foxes, technical difficulties precluded the full development of species-specific VVIC vaccines for field release. [95] Nevertheless, the approach still offers an excellent promise as a disseminating or non-disseminating delivery system for immunocontraceptive antigens to pest mammals.…”

Section: Formulation Of Non-living Vaccinesmentioning

confidence: 99%

Formulation and delivery of vaccines: Ongoing challenges for animal management

Sharma

Hinds

2012

J Pharm Bioall Sci

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Development of a commercially successful animal vaccine is not only influenced by various immunological factors, such as type of antigen but also by formulation and delivery aspects. The latter includes the need for a vector or specific delivery system, the choice of route of administration and the nature of the target animal population and their habitat. This review describes the formulation and delivery aspects of various types of antigens such as killed microorganisms, proteins and nucleic acids for the development of efficacious and safe animal vaccines. It also focuses on the challenges associated with the different approaches that might be required for formulating and delivering species specific vaccines, particularly if their intended use is for improved animal management with respect to disease and/or reproductive control.

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“…The speciestailoring process can either be achieved through the vaccinecompound itself or the delivery method. Examples of the former include vectored immunocontraception for foxes, rabbits and mice (McLeod et al 2007;Redwood et al 2007;Strive et al 2007;Tyndale-Biscoe and Hinds 2007;Van Leeuwen and Kerr 2007) or the University of Newcastle's phage bio-panning technique (Aitken 2006). Current orally deliverable actives being investigated, such as GnRH or VCD will, however, require specificity in their respective delivery methods.…”

Section: The Species-tailoring Processmentioning

confidence: 99%

Delivering and registering species-tailored oral antifertility products: a review

Humphrys¹,

Lapidge²

2008

Wildl. Res.

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Technologies that induce infertility in wildlife are advancing rapidly. This is due largely to our increasing understanding of reproductive physiology, as well as the demand for management techniques that reduce fertility rather than increase mortality. However, transferring wildlife fertility control from the laboratory into landscape-scale utility for free-ranging animal populations will be highly dependent on products possessing oral activity and cost-effectiveness. A significant challenge to the delivery process is providing the international regulators in each jurisdiction with the most relevant data packages they need to assess new products. An essential part of any product registration for free-ranging animals will be the development of species-tailored delivery systems, especially so for non-specific antifertility actives. This review examines the current range of orally deliverable antifertility options, broadly classifies them according to overall risk compared with alternative vertebrate pesticides, outlines a species-tailoring process that reduces identified risks, and encompasses the data requirements for their registration for sale in Australasia, the USA and Europe.

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Introduction - virally vectored immunocontraception in Australia

Cited by 13 publications

References 31 publications

Fertility control to mitigate human–wildlife conflicts: a review

Fertility control to mitigate human–wildlife conflicts: a review

Formulation and delivery of vaccines: Ongoing challenges for animal management

Delivering and registering species-tailored oral antifertility products: a review

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