Introduction to the ZENITH study and summary of baseline results

Coudray, Charles; O’Connor, Jacqueline M.; Maiani, Giuseppe; Cashman, Kevin D.; Simpson, E.; Secker, David L.; Ferry, M.; Roussel, Anne‐Marie

doi:10.1038/sj.ejcn.1602304

Cited by 12 publications

(8 citation statements)

References 15 publications

(12 reference statements)

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“…Reports on vitamin D deficiency in the elderly (Coudray et al, 2005, Annweiler et al, 2010, Annweiler et al, 2012) is extended in the present study where we show that aged animals are deficient in the active form of vitamin D, 1, α25-dihydroxyvitamin D3. The age-related deficiency in vitamin D demonstrated here may be due to decrease production and/or increase metabolic clearance rate because of the high levels of 24-hydroxylase, enzyme that metabolize vitamin D, seen in the elderly [reviewed in (Tuohimaa et al, 2009)].…”

Section: Discussionsupporting

confidence: 65%

“…One of the hormones gaining increasing support as a therapeutic agent to provide neuroprotection in the aging brain is vitamin D. The prevalence of chronic low serum vitamin D concentration in the elderly is estimated to be 50–80% (Nesby-O'Dell et al, 2002, Coudray et al, 2005). More recently, a meta-analysis report shows that vitamin D concentration is even lower in patients with Alzheimer's disease when compared to age-matched controls (Annweiler et al, 2013).…”

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confidence: 99%

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Retraction notice to “DECREASE IN AGE-RELATED TAU HYPERPHOSPHORYLATION AND COGNITIVE IMPROVEMENT FOLLOWING VITAMIN D SUPPLEMENTATION ARE ASSOCIATED WITH MODULATION OF BRAIN ENERGY METABOLISM AND REDOX STATE” Neuroscience 262 (2014) 143–155

Briones

Darwish

2014

Neuroscience

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In the present study we examined whether vitamin D supplementation can reduce age-related tau hyperphosphorylation and cognitive impairment by enhancing brain energy homeostasis and protein phosphatase-2A (PP2A) activity, and modulating the redox state. Male F344 rats age 20 months (aged) and 6 months (young) were randomly assigned to either vitamin D supplementation or no supplementation (control). Rats were housed in pairs and the supplementation group (n=10 young and n=10 aged) received subcutaneous injections of vitamin D (1, α25-dihydroxyvitamin D3) for 21 days. Control animals (N=10 young and n=10 aged) received equal volume of normal saline and behavioral testing in water maze started on day 14 after initiation of vitamin D supplementation. Tau phosphorylation, markers of brain energy metabolism (ADP/ATP ratio and adenosine monophosphate-activated protein kinase) and redox state (levels of reactive oxygen species, activity of superoxide dismutase, and glutathione levels) as well as PP2A activity were measured in hippocampal tissues. Our results extended previous findings that: 1) tau phosphorylation significantly increased during aging; 2) markers of brain energy metabolism and redox state are significantly decreased in aging; and 3) aged rats demonstrated significant learning and memory impairment. More importantly, we found that age-related changes in brain energy metabolism, redox state, and cognitive function were attenuated by vitamin D supplementation. No significant differences were seen in tau hyperphosphorylation, markers of energy metabolism and redox state in the young animal groups. Our data suggests that vitamin D ameliorated the age-related tau hyperphosphorylation and cognitive decline by enhancing brain energy metabolism, redox state, and PP2A activity making it a potentially useful therapeutic option to alleviate the effects of aging.

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Section: Discussionsupporting

confidence: 65%

mentioning

confidence: 99%

Retraction notice to “DECREASE IN AGE-RELATED TAU HYPERPHOSPHORYLATION AND COGNITIVE IMPROVEMENT FOLLOWING VITAMIN D SUPPLEMENTATION ARE ASSOCIATED WITH MODULATION OF BRAIN ENERGY METABOLISM AND REDOX STATE” Neuroscience 262 (2014) 143–155

Briones

Darwish

2014

Neuroscience

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“…Recently, it has been shown that zinc might play an important role for behavioural and mental function, antioxidant system and metabolism, especially in elderly . Other studies have shown that zinc plays a beneficial effect in terms of reducing adverse psychological conditions Coudray et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Zinc status, psychological and nutritional assessment in old people recruited in five European countries: Zincage study

et al. 2006

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The paper shows the results on the relationship between zinc status, psychological dimensions (cognitive functions, mood, perceived stress) and nutritional aspects in European healthy old subjects recruited for ZINCAGE Project (supported by the European Commission in the Sixth Framework Programme). The old healthy subjects were recruited in Italy, Greece, Germany, France, Poland taking into account the different dietary habits between Northern and Southern European Countries and the pivotal role played by zinc for psychological functions. Measures of the cognitive status, mood and perceived stress level were obtained at baseline, using the "Mini Mental State Examination (MMSE)"; the "Geriatric Depression Scale (GDS - 15 items)" and the "Perceived Stress Scale (PSS)", respectively. Nutritional status was assessed using "Frequency Food Questionnaire". The sample included 853 old subjects, classified in 4 groups of age: 60-69-years-old (n = 359); 70-74-years-old (n = 225); 75-79-years-old (n = 153); 80-84-years-old (n = 116). Subjects were studied on the basis of plasma zinc, in which zinc

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“…The study design parameters of the multi-centre ZENITH study have been reported in detail previously (Coudray et al, 2005;Polito et al, 2005;Simpson et al, 2005). The present study investigated the baseline association between serum 25(OH)D and nonverbal tests of cognitive function within these subjects.…”

Section: Designmentioning

confidence: 99%

Vitamin D status and measures of cognitive function in healthy older European adults

et al. 2010

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Background/Objectives: Data from human studies that have investigated the association between vitamin D status and cognitive function in elderly adults are conflicting. The objective of this study was to assess vitamin D status (reflected by serum 25-hydroxyvitamin D (25(OH)D)) in older European subjects (n ¼ 387; aged 55-87 years) and examine its association with measures of cognitive function. Subjects/Methods: Serum 25(OH)D was assessed using enzyme-linked immunosorbent assay, whereas measures of cognitive function were assessed using a comprehensive Cambridge Neuropsychological Testing Automated Battery (CANTAB). Results: In all, 12, 36 and 64% of subjects had serum 25(OH)D concentrations o30, o50 and o80 nmol/l, respectively, throughout the year. Serum 25(OH)D was significantly and inversely correlated with four assessments within the spatial working memory (SWM) test parameter (SWM between errors (r ¼ À0.166; P ¼ 0.003); SWM between errors 8 boxes (r ¼ À0.134; P ¼ 0.038); SWM strategy (r ¼ À0.246; Po0.0001); and SWM total errors (r ¼ À0.174; Po0.003)). When subjects were stratified on the basis of tertiles (T) of serum 25(OH)D (o47.6 (T 1 ); 47.6-85.8 (T 2 ); and 485.8 (T 3 ) nmol/l), fewer errors in SWM test scores occurred in subjects in the third T when compared with the first T (Po0.05-0.084). Stratification by sex showed that these differences between tertiles strengthened (Po0.001-0.043) in the females, but the differences were not significant (P40.6) in males. Conclusions: Vitamin D insufficiency, but not deficiency, is widespread in the older population of several European countries. Low vitamin D status was associated with a reduced capacity for SWM, particularly in women.

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Introduction to the ZENITH study and summary of baseline results

Cited by 12 publications

References 15 publications

Retraction notice to “DECREASE IN AGE-RELATED TAU HYPERPHOSPHORYLATION AND COGNITIVE IMPROVEMENT FOLLOWING VITAMIN D SUPPLEMENTATION ARE ASSOCIATED WITH MODULATION OF BRAIN ENERGY METABOLISM AND REDOX STATE” Neuroscience 262 (2014) 143–155

Retraction notice to “DECREASE IN AGE-RELATED TAU HYPERPHOSPHORYLATION AND COGNITIVE IMPROVEMENT FOLLOWING VITAMIN D SUPPLEMENTATION ARE ASSOCIATED WITH MODULATION OF BRAIN ENERGY METABOLISM AND REDOX STATE” Neuroscience 262 (2014) 143–155

Zinc status, psychological and nutritional assessment in old people recruited in five European countries: Zincage study

Vitamin D status and measures of cognitive function in healthy older European adults

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