Introduction to the Toxins Special Issue “Ricin Toxins”

Tumer, Nilgun E.

doi:10.3390/toxins12010013

Cited by 4 publications

(2 citation statements)

References 14 publications

(9 reference statements)

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“…In our analyses, the dynamics of the C-terminal uL10 variants, irrespective of the modifications tested, resembled that of the wild-type, showing that this region has no role in the interplay of uL10 with the ribosome. In line with this observation are published data showing that this C terminus represents a critical part of the ribosomal stalk, which governs the interaction with translational GTPases or RIPs [31,70,71] and plays a decisive role in the biological activity of P-proteins [25]. Importantly, our recent analyses indicate that the phosphorylation of the C terminus significantly influences the kinetics of the interaction between stalk proteins and external factors (personal communication from M. Tchorzewski, 2020).…”

Section: Discussionsupporting

confidence: 73%

Phosphorylation of the N‐terminal domain of ribosomal P‐stalk protein uL10 governs its association with the ribosome

et al. 2020

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The uL10 protein is the main constituent of the ribosomal P‐stalk, anchoring the whole stalk to the ribosome through interactions with rRNA. The P‐stalk is the core of the GTPase‐associated center (GAC), a critical element for ribosome biogenesis and ribosome translational activity. All P‐stalk proteins (uL10, P1, and P2) undergo phosphorylation within their C termini. Here, we show that uL10 has multiple phosphorylation sites, mapped also within the N‐terminal rRNA‐binding domain. Our results reveal that the introduction of a negative charge within the N terminus of uL10 impairs its association with the ribosome. These findings demonstrate that uL10 N‐terminal phosphorylation has regulatory potential governing the uL10 interaction with the ribosome and may control the activity of GAC.

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Section: Discussionsupporting

confidence: 73%

Phosphorylation of the N‐terminal domain of ribosomal P‐stalk protein uL10 governs its association with the ribosome

et al. 2020

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“…Unfortunately, castor also contains ricin, which represents the most toxic vegetable compound known [11]. The lethal dose for adult humans is 0.35-0.7 mg kg −1 of body weight by inhalation, whereas by ingestion has been estimated to be between 1 and 20 mg kg −1 of body weight.…”

Section: Noxious Compounds: Ricine and Its Homologuementioning

confidence: 99%

Opportunities and Challenges of Castor Bean (Ricinus communis L.) Genetic Improvement

et al. 2023

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Castor bean (Ricinus communis L.) originated in East Africa and then diffused to warm-temperate, subtropical, and tropical regions of the world. The high lipid content in the castor beans is extracted for use in pharmaceutical and industrial applications. The castor oil lipid profile is naturally composed of 90% ricinoleic acid and the remaining 10% is mainly composed of linoleic, oleic, stearic, and linolenic fatty acids. The highly toxic compound ricin within the seeds is insoluble in oil, making castor oil free from this toxin and safe to use for industrial and cosmetic applications. Among the main uses of castor oil are reported industrial uses such as component for lubricants, paints, coatings, polymers, emulsifiers, cosmetics, and medicinal uses as a laxative. There is also significant commercial potential for utilization of the whole castor bean plant such as animal feed, fertilizer, biofuel, and also for phytoremediation. Several breeding programs have been planned to improve the castor’s characteristics needed for its current or potential uses. In this review, after summarizing data on castor bean agronomy and uses, we focus on the main advances in Castor bean classical and biotechnological breeding programs, underlining the high potential of this oil crop. In particular, the main challenges of castor breeding programs are to increase yield, mainly through the selection of growth habits allowing mechanized harvest, and beneficial compound content, mainly the oil, and to decrease the toxic compounds content, mainly ricin.

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Detoxification of three toxins in castor meal by a novel continuous phase-transition extraction in a pilot-scale

Guo

Liao

Guo

et al. 2021

Industrial Crops and Products

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Introduction to the Toxins Special Issue “Ricin Toxins”

Abstract: Ricin toxin isolated from the castor bean (Ricinus communis) is one of the most potent and lethal molecules known [...]

Cited by 4 publications

References 14 publications

Phosphorylation of the N‐terminal domain of ribosomal P‐stalk protein uL10 governs its association with the ribosome

Phosphorylation of the N‐terminal domain of ribosomal P‐stalk protein uL10 governs its association with the ribosome

Opportunities and Challenges of Castor Bean (Ricinus communis L.) Genetic Improvement

Detoxification of three toxins in castor meal by a novel continuous phase-transition extraction in a pilot-scale

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