Introduction to the Symposium--Keeping Time During Evolution: Conservation and Innovation of the Circadian Clock

Tarrant, Ann M.; Reitzel, Adam M.

doi:10.1093/icb/ict062

Cited by 4 publications

(3 citation statements)

References 15 publications

(5 reference statements)

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“…Since the circadian clock is conserved across species (25), we sought to investigate whether these seven largely uncharacterized genes have functional homologs that might play a role in the mammalian clock pacemaker. We found that five of them (Amph, Gclm, CG14688, CG31324, and CG2277) have orthologs in mouse (Mus musculus), baboon (Papio anubis), and human (Homo sapiens) (table S5).…”

Section: Tissue-specific Cycling Genes and Putative Core Circadian Co...mentioning

confidence: 99%

Extensive tissue-specific expression variation and novel regulators underlying circadian behavior

et al. 2021

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Natural genetic variation affects circadian rhythms across the evolutionary tree, but the underlying molecular mechanisms are poorly understood. We investigated population-level, molecular circadian clock variation by generating >700 tissue-specific transcriptomes of Drosophila melanogaster (w1118) and 141 Drosophila Genetic Reference Panel (DGRP) lines. This comprehensive circadian gene expression atlas contains >1700 cycling genes including previously unknown central circadian clock components and tissue-specific regulators. Furthermore, >30% of DGRP lines exhibited aberrant circadian gene expression, revealing abundant genetic variation–mediated, intertissue circadian expression desynchrony. Genetic analysis of one line with the strongest deviating circadian expression uncovered a novel cry mutation that, as shown by protein structural modeling and brain immunohistochemistry, disrupts the light-driven flavin adenine dinucleotide cofactor photoreduction, providing in vivo support for the importance of this conserved photoentrainment mechanism. Together, our study revealed pervasive tissue-specific circadian expression variation with genetic variants acting upon tissue-specific regulatory networks to generate local gene expression oscillations.

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Section: Tissue-specific Cycling Genes and Putative Core Circadian Co...mentioning

confidence: 99%

Extensive tissue-specific expression variation and novel regulators underlying circadian behavior

et al. 2021

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“…The circadian pattern is evolutionarily conserved in human and other organisms, setting daily rhythms in behaviors and physiology (89,119). In mammals, neurons in the suprachiasmatic nucleus (SCN) of the hypothalamus undergo synchronized daily oscillations to generate diurnal patterns of rhythmic circuits of action potential firing (41,132).…”

Section: Circadian Clockmentioning

confidence: 99%

Ball-and-Chain Inactivation in Potassium Channels

Sukomon

Chen

Nimigean

2023

Annu. Rev. Biophys.

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Carefully orchestrated opening and closing of ion channels controls the diffusion of ions across cell membranes, generating the electrical signals required for fast transmission of information throughout the nervous system. Inactivation is a parsimonious means for channels to restrict ion conduction without the need to remove the activating stimulus. Voltage-gated channel inactivation plays crucial physiological roles, such as controlling action potential duration and firing frequency in neurons. The ball-and-chain moniker applies to a type of inactivation proposed first for sodium channels and later shown to be a universal mechanism. Still, structural evidence for this mechanism remained elusive until recently. We review the ball-and-chain inactivation research starting from its introduction as a crucial component of sodium conductance during electrical signaling in the classical Hodgkin and Huxley studies, through the discovery of its simple intuitive mechanism in potassium channels during the molecular cloning era, to the eventual elucidation of a potassium channel structure in a ball-and-chain inactivated state. Expected final online publication date for the Annual Review of Biophysics, Volume 52 is May 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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“…Hypoxia signaling and the circadian clock are closely related and heavily cross-communicating pathways ( 5 ). Both pathways are evolutionarily ancient, presenting the first molecular mechanisms allowing living organisms to adapt to environmental stimuli on earth (light/dark cycles and the strongly oxidative environment respectively) ( 47 – 50 ). Interestingly, the core components of these pathways belong to the same family of transcription factors and are regulated in a very similar fashion.…”

Section: Hypoxia and The Circadian Clock–to Sides Of The Same Coin?mentioning

confidence: 99%

Hypoxia Signaling and Circadian Disruption in and by Pheochromocytoma

2018

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Disruption of the daily (i.e., circadian) rhythms of cell metabolism, proliferation and blood perfusion is a hallmark of many cancer types, perhaps most clearly exemplified by the rare but detrimental pheochromocytomas. These tumors arise from genetic disruption of genes critical for hypoxia signaling, such as von Hippel-Lindau and hypoxia-inducible factor-2 or cellular metabolism, such as succinate dehydrogenase, which in turn impacts on the cellular circadian clock function by interfering with the Bmal1 and/or Clock transcription factors. While pheochromocytomas are often non-malignant, the resulting changes in cellular physiology are coupled to de-regulated production of catecholamines, which in turn disrupt circadian blood pressure variation and therefore circadian entrainment of other tissues. In this review we thoroughly discuss the molecular and physiological interplay between hypoxia signaling and the circadian clock in pheochromocytoma, and how this underlies endocrine disruption leading to loss of circadian blood pressure variation in the affected patients. We furthermore discuss potential avenues for targeting these tumor-specific pathophysiological mechanisms therapeutically in the future.

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Introduction to the Symposium--Keeping Time During Evolution: Conservation and Innovation of the Circadian Clock

Cited by 4 publications

References 15 publications

Extensive tissue-specific expression variation and novel regulators underlying circadian behavior

Extensive tissue-specific expression variation and novel regulators underlying circadian behavior

Ball-and-Chain Inactivation in Potassium Channels

Hypoxia Signaling and Circadian Disruption in and by Pheochromocytoma

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