Introduction to the special section on proteins and proteomics

Normal Mouse Brain Proteome II: Analysis of Brain Regions by High-resolution Mass Spectrometry

“…Protein levels cannot be extrapolated from mRNA levels, making increasing the sensitivity of proteomics techniques mandatory. Apart from the large numbers of splice variants, the enormous complexity and diversity of proteins is also a result of their post-translational modifications (PTMs), which cannot be assessed using transcriptional studies (14).…”