Introduction to the Special Issue on the Exposome—Understanding Environmental Impacts on Brain Development and Risk for Psychopathology

Barch, Deanna M.

doi:10.1016/j.bpsgos.2022.05.007

Cited by 6 publications

(5 citation statements)

References 33 publications

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“…Epidemiological studies show that most children with neurodevelopmental disorders live in countries in the Global South [108]. Infants who experience early social adversity are at increased risk for behavioral, emotional, and cognitive disturbances [113]. This vulnerability results from the complex interaction between endogenous and exogenous factors that occur more frequently in these countries and that include, as described in this work, genetic and epigenetic mechanisms and environmental stressors such as exposure to maternal infections, obstetric complications, exposure to natural or synthetic chemicals, exposure to environmental stressors, exposure to natural or synthetic chemicals and nutritional deficiencies during preconception and pregnancy, as well as demographic variables such as sex, socioeconomic status, parental education level, poverty, or living in a neighborhood with a high crime rate or with low access to green spaces free of environmental pollution [114][115][116].…”

Section: Discussionmentioning

confidence: 99%

Neuropsychology and Electroencephalography in Rural Children at Neurodevelopmental Risk: A Scoping Review

Galindo-Aldana,

Torres-González

2023

Pediatric Reports

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Children from rural areas face numerous possibilities of neurodevelopmental conditions that may compromise their well-being and optimal development. Neuropsychology and electroencephalography (EEG) have shown strong agreement in detecting correlations between these two variables and suggest an association with specific environmental and social risk factors. The present scoping review aims to describe studies reporting associations between EEG features and cognitive impairment in children from rural or vulnerable environments and describe the main risk factors influencing EEG abnormalities in these children. The method for this purpose was based on a string-based review from PubMed, EBSCOhost, and Web of Science, following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Qualitative and quantitative analyses were conducted from the outcomes that complied with the selected criteria. In total, 2280 records were identified; however, only 26 were eligible: 15 for qualitative and 11 for quantitative analysis. The findings highlight the significant literature on EEG and its relationship with cognitive impairment from studies in children with epilepsy and malnutrition. In general, there is evidence for the advantages of implementing EEG diagnosis and research techniques in children living under risk conditions. Specific associations between particular EEG features and cognitive impairment are described in the reviewed literature in children. Further research is needed to better describe and integrate the state of the art regarding EEG feature extraction.

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Section: Discussionmentioning

confidence: 99%

Neuropsychology and Electroencephalography in Rural Children at Neurodevelopmental Risk: A Scoping Review

Galindo-Aldana,

Torres-González

2023

Pediatric Reports

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“…Ultimately, more work is needed that embeds the developing brain within a multilevel model of influence. At the very least, a recent focus on broader structural factors (e.g., neighborhood disadvantage, structural racism; Barch, 2022;Dumornay et al, 2023;Tomlinson et al, 2020) demonstrates increasing appreciation that more distal factors influence brain development. Looking forward, a shift in where the field focuses (e.g., structural vs. family factors) and an appreciation for how risk filters across levels, is important in terms of the policy implications that will follow from this work (Hyde et al, 2020).…”

Section: Applications To Developmental Neurosciencementioning

confidence: 99%

The future of neuroscience in developmental psychopathology

Hyde,

Bezek,

Michael

2024

Dev Psychopathol

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Developmental psychopathology started as an intersection of fields and is now a field itself. As we contemplate the future of this field, we consider the ways in which a newer, interdisciplinary field – human developmental neuroscience – can inform, and be informed by, developmental psychopathology. To do so, we outline principles of developmental psychopathology and how they are and/or can be implemented in developmental neuroscience. In turn, we highlight how the collaboration between these fields can lead to richer models and more impactful translation. In doing so, we describe the ways in which models from developmental psychopathology can enrich developmental neuroscience and future directions for developmental psychopathology.

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“…The period encompassing pregnancy and the first two years after birth -the perinatal period- has also been termed ‘the first 1000 days’ or ‘the first 1001 critical days’. Furthermore, preclinical, epidemiological, and clinical studies indicate that perinatal adaptations to adverse environmental factors (e.g., parental psychosocial stress, health problems, unhealthy life style factors, toxic chemicals, air pollution) and to promotive factors (e.g., parental resilience, health, stable and supportive context, green space), in interaction with genetic susceptibility and timing, intensity and duration of the exposure, may influence offspring endocrine, immune, metabolic, microbiome, and other biological systems, which in turn can affect offspring neurobehavioral development [5 ▪ ,6–13].…”

Section: Introductionmentioning

confidence: 99%

Current perspectives on perinatal mental health and neurobehavioral development: focus on regulation, coregulation and self-regulation

Van den Bergh,

Antonelli,

Stein

2024

Current Opinion in Psychiatry

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Purpose of review Perinatal mental health research provides an important perspective on neurobehavioral development. Here, we aim to review the association of maternal perinatal health with offspring neurodevelopment, providing an update on (self-)regulation problems, hypothesized mechanistic pathways, progress and challenges, and implications for mental health. Recent findings (1) Meta-analyses confirm that maternal perinatal mental distress is associated with (self-)regulation problems which constitute cognitive, behavioral, and affective social-emotional problems, while exposure to positive parental mental health has a positive impact. However, effect sizes are small. (2) Hypothesized mechanistic pathways underlying this association are complex. Interactive and compensatory mechanisms across developmental time are neglected topics. (3) Progress has been made in multiexposure studies. However, challenges remain and these are shared by clinical, translational and public health sciences. (4) From a mental healthcare perspective, a multidisciplinary and system level approach employing developmentally-sensitive measures and timely treatment of (self-)regulation and coregulation problems in a dyadic caregiver-child and family level approach seems needed. The existing evidence-base is sparse. Summary During the perinatal period, addressing vulnerable contexts and building resilient systems may promote neurobehavioral development. A pluralistic approach to research, taking a multidisciplinary approach to theoretical models and empirical research needs to be fostered.

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Introduction to the Special Issue on the Exposome—Understanding Environmental Impacts on Brain Development and Risk for Psychopathology

Cited by 6 publications

References 33 publications

Neuropsychology and Electroencephalography in Rural Children at Neurodevelopmental Risk: A Scoping Review

Neuropsychology and Electroencephalography in Rural Children at Neurodevelopmental Risk: A Scoping Review

The future of neuroscience in developmental psychopathology

Current perspectives on perinatal mental health and neurobehavioral development: focus on regulation, coregulation and self-regulation

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