Introduction to the Global Scenario of Marine Sponge Research

Bramhachari, Pallaval Veera; Ehrlich, Hermann; Pallela, Ramjee

doi:10.1007/978-81-322-2794-6_1

Cited by 3 publications

(4 citation statements)

References 194 publications

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“…The unique conditions of the marine environment, such as high pressure and salinity, coupled with the need to defend against predators and microorganisms, have led to a wide range of secondary metabolites in sponges. These metabolites possess medicinal properties that are distinct from those found in terrestrial plants [ 3 ]. The number of such metabolites found in sponges by now is more than 5300.…”

Section: Introductionmentioning

confidence: 99%

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Triterpene and Steroid Glycosides from Marine Sponges (Porifera, Demospongiae): Structures, Taxonomical Distribution, Biological Activities

Ivanchina

Kalinin

2023

Molecules

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The article is a comprehensive review concerning tetracyclic triterpene and steroid glycosides from sponges (Porifera, Demospongiae). The extensive oxidative transformations of the aglycone and the use of various monosaccharide residues, with up to six possible, are responsible for the significant structural diversity observed in sponge saponins. The saponins are specific for different genera and species but their taxonomic distribution seems to be mosaic in different orders of Demospongiae. Many of the glycosides are membranolytics and possess cytotoxic activity that may be a cause of their anti-predatory activities. All these data reveal the independent origin and parallel evolution of the glycosides in different taxa of the sponges. The information concerning chemical structures, biological activities, biological role, and taxonomic distribution of the sponge glycosides is discussed.

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Section: Introductionmentioning

confidence: 99%

“…It is known that many sponge metabolites may be synthesized by symbiotic microorganisms [ 3 ]. However, the enzymes responsible for terpene biosynthesis were found recently in sponges but not in symbiotic microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Triterpene and Steroid Glycosides from Marine Sponges (Porifera, Demospongiae): Structures, Taxonomical Distribution, Biological Activities

Ivanchina

Kalinin

2023

Molecules

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“…To date, more than 20,000 compounds have been isolated from marine sponges (phylum Porifera) of which more than 5,300 show a diverse range of bioactivities including antimicrobial, antitumor, and anti-inflammatory activities [1]. The production of sponge bioactive compounds may be partly used by the marine sponges for chemical defences in response to various environmental challenges [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation: Isolation of bromopyrrole alkaloids from Stylissa massa

Kosgahakumbura,

Gamage,

Robertson

et al. 2024

PLoS ONE

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Sri Lanka is a biodiversity hotspot and one of the richest geographical locations of marine sponges in the Indian ocean. However, the most extensive taxonomical study on Sri Lankan sponge biodiversity dates back ~100 years and only a limited number of studies have been conducted on sponge natural products. In the current study, 35 marine sponge specimens (collected from 16 sponge habitats around Sri Lanka) were identified, microfractionated and evaluated for antibacterial and anticancer assays. In total, 30 species were characterized, of which 19 species gave extracts with antibacterial and/or cytotoxic activities. Microfractionated organic extract of Aciculites orientalis gave the most potent antibacterial activity against Staphylococcus aureus and strongest lymphoma cell toxicity was exhibited by the organic extract of Acanthella sp. Guided by the molecular ion peaks in the bioactive fractions, large-scale extraction of Stylissa massa led to the isolation of three bromopyrrole alkaloids, sceptrin, hymenin and manzacidin A/C. Of these, sceptrin exhibited broad spectrum antibacterial activity against both Escherichia coli and S. aureus (MIC of 62.5 μM against both species). Based on natural product literature, seven promising species were identified as understudied. Their further exploration may lead to the discovery of structurally novel compounds.

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“…Aside from the many abiotic factors, the sponge must also deter predators, such as fish (Dunlap and Pawlik, 1996), molluscs (Pawlik et al, 1988), echinoderms (Waddell and Pawlik, 2000), and urchins (Ayling, 1981), as well as compete for space in a constant battle of arms against other marine organisms within the reef ecosystem (Alino et al, 1992;Aerts, 2000). Due to the sponge's simplistic anatomy, it is limited in its capability to protect itself from many of these environmental constraints (Bramhachari et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Prodiginine Pathway in Marine Sponge-Associated Pseudoalteromonas sp. PPB1 in Hilo, Hawai‘i

Sakai-Kawada

Hagiwara

et al. 2020

Front. Sustain. Food Syst.

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Interest in bioactive pigments stems from their ecological role in adaptation, as well as their applications in various consumer products. The production of these bioactive pigments can be from a variety of biological sources, including simple microorganisms that may or may not be associated with a host. This study is particularly interested in the marine sponges, which have been known to harbor microorganisms that produce secondary metabolites like bioactive pigments. In this study, marine sponge tissue samples were collected from Puhi Bay off the Eastern shore of Hilo, Hawai‘i and subsequently were identified as Petrosia sp. with red pigmentation. Using surface sterilization and aseptic plating of sponge tissue samples, sponge-associated microorganisms were isolated. One isolate (PPB1) produced a colony with red pigmentation like that of Petrosia sp., suggesting an integral relationship between this particular isolate and the sponge of interest. 16S characterization and sequencing of PPB1 revealed that it belonged to the Pseudoalteromonas genus. Using various biological assays, both antimicrobial and antioxidant bioactivity was shown in Pseudoalteromonas sp. PPB1 crude extract. To further investigate the genetics of pigment production, a draft genome of PPB1 was sequenced, assembled, and annotated. This revealed a prodiginine biosynthetic pathway and the first cited-incidence of a prodiginine-producing Pseudoalteromonas species isolated from a marine sponge host. Further understanding into the bioactivity and biosynthesis of secondary metabolites like pigmented prodiginine may uncover the complex ecological interactions between host sponge and microorganism.

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Introduction to the Global Scenario of Marine Sponge Research

Cited by 3 publications

References 194 publications

Triterpene and Steroid Glycosides from Marine Sponges (Porifera, Demospongiae): Structures, Taxonomical Distribution, Biological Activities

Triterpene and Steroid Glycosides from Marine Sponges (Porifera, Demospongiae): Structures, Taxonomical Distribution, Biological Activities

Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation: Isolation of bromopyrrole alkaloids from Stylissa massa

Characterization of Prodiginine Pathway in Marine Sponge-Associated Pseudoalteromonas sp. PPB1 in Hilo, Hawai‘i

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