Introduction to the feature issue on the 25 year anniversary of optical coherence tomography

Izatt, Joseph A.; Boppart, Stephen A.; Bouma, Brett E.; Boer, J. de; Drexler, Wolfgang; Li, Xingde; Yasuno, Yoshiaki

doi:10.1364/boe.8.003289

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…Optical coherence tomography is one of the standard tools to image and measure the retinal thickness ( 15 ) and the anterior chamber for angle closure ( 16 ) for the diagnosis and management of some eye diseases in ophthalmologic clinics. OCT has also been used in animal models to measure biometric properties of the eye longitudinally ( 17 – 19 ), it provides an effective tool to determine anterior segment features, the lens, and the retina in different mouse eye models in vivo ( 20 – 23 ).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal study of microphthalmia in connexin 50 knockout mice using spectral-domain optical coherence tomography

Painter,

Ou,

Gong

et al. 2024

Front. Ophthalmol.

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Connexin 50 (Cx50) mediated signaling is essential for controlling the lens growth and size. Cx50 mutations cause microphthalmia, smaller lenses, and cataracts in humans and animals. These ocular defects have never been investigated in live Cx50 mutant mice by using non-invasive imaging techniques. Here, we report a longitudinal study of the ocular defects in Cx50 knockout (Cx50KO) mice from the ages of 3 weeks to 12 months by using spectral-domain optical coherence tomography (SD-OCT). The anterior chamber depth (ACD), lens thickness (LT), vitreous chamber depth (VCD), and axial length (AL) were measured along the visual axis and adjusted with corresponding refractive indices. The SD-OCT image data confirm age-related reductions of LT and AL in live Cx50KO mice compared to age-matched wild-type (WT) controls, and the reduction values are comparable to the in vitro measurements of Cx50KO eyeballs and lenses reported previously. Moreover, reductions of ACD were observed in Cx50KO mice at all ages studied while VCD changes are statistically insignificant in comparison to the WT controls. Therefore, Cx50KO’s microphthalmia with small lens is selectively associated with delayed ACD development but not the vitreous formation. This work supports the notion that lens size and/or growth is important for anterior chamber development.

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Section: Introductionmentioning

confidence: 99%

Longitudinal study of microphthalmia in connexin 50 knockout mice using spectral-domain optical coherence tomography

Painter,

Ou,

Gong

et al. 2024

Front. Ophthalmol.

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“…And the optical pathlength data can be further converted into various biologically-relevant information [2][3][4]. Kinds of QPI techniques, such as optical coherence tomography (OCT) [5,6], digital holographic microscopy (DHM) [7,8], diffraction phase microscopy (DPM) [9,10], transport of intensity equation (TIE) [11,12], optical diffraction tomography (ODT) [13,14], and so on, have been developed to help access to this valuable phase information.…”

Section: Introductionmentioning

confidence: 99%

Deep-Learning-Based Halo-Free White-Light Diffraction Phase Imaging

Zhang

Zhu

et al. 2021

Front. Phys.

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In white-light diffraction phase imaging, when used with insufficient spatial filtering, phase image exhibits object-dependent artifacts, especially around the edges of the object, referred to the well-known halo effect. Here we present a new deep-learning-based approach for recovering halo-free white-light diffraction phase images. The neural network-based method can accurately and rapidly remove the halo artifacts not relying on any priori knowledge. First, the neural network, namely HFDNN (deep neural network for halo free), is designed. Then, the HFDNN is trained by using pairs of the measured phase images, acquired by white-light diffraction phase imaging system, and the true phase images. After the training, the HFDNN takes a measured phase image as input to rapidly correct the halo artifacts and reconstruct an accurate halo-free phase image. We validate the effectiveness and the robustness of the method by correcting the phase images on various samples, including standard polystyrene beads, living red blood cells and monascus spores and hyphaes. In contrast to the existing halo-free methods, the proposed HFDNN method does not rely on the hardware design or does not need iterative computations, providing a new avenue to all halo-free white-light phase imaging techniques.

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“…The en face FFOCT retinal images reveal information about various structures, such as the nerve fiber orientation, the blood vessel distribution, and the photoreceptor mosaic. During its 25 years of development, optical coherence tomography (OCT) has become a powerful imaging modality in biomedical and clinical studies [1,2]. It has achieved great success in ophthalmology [3], especially in retinal imaging for which it has been entitled the "virtual biopsy" for human retina [4].…”

mentioning

confidence: 99%

In vivo high-resolution human retinal imaging with wavefront-correctionless full-field OCT

Xiao¹,

Mazlin²,

Grieve³

et al. 2018

Optica

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As the lateral resolution of full-field optical coherence tomography (FFOCT) with spatially incoherent illumination has been shown to be insensitive to aberrations, we demonstrate high-resolution en face FFOCT retinal imaging without wavefront correction in the human eye in vivo for the first time, to our knowledge. A combination of FFOCT with spectraldomain OCT (SDOCT) is applied for real-time matching of the optical path lengths (OPLs) of FFOCT. Through the realtime cross-sectional SDOCT images, the OPL of the FFOCT reference arm is matched with different retinal layers in the FFOCT sample arm. Thus, diffraction-limited FFOCT images of multiple retinal layers are acquired at both the near periphery and the fovea. The en face FFOCT retinal images reveal information about various structures, such as the nerve fiber orientation, the blood vessel distribution, and the photoreceptor mosaic. During its 25 years of development, optical coherence tomography (OCT) has become a powerful imaging modality in biomedical and clinical studies [1,2]. It has achieved great success in ophthalmology [3], especially in retinal imaging for which it has been entitled the "virtual biopsy" for human retina [4]. Compared with typical retinal imaging modalities like fundus cameras [5] or scanning laser ophthalmoscopy (SLO) [6], in which axial resolution is limited by the finite size of the eye's pupil, OCT offers much higher axial sectioning, as the lateral and axial resolutions are decoupled. The high-resolution cross-sectional depth exploration of the retinal layers offers important information about pathologies for early diagnosis of disease and for tracing disease evolution [7][8][9]. While doctors are capable of interpreting crosssectional OCT slices, there is nevertheless a need for en face views, as shown by the continued use of en face techniques such as fundus cameras or SLO. Thanks to the speed improvement, OCT systems can provide en face retinal images by doing real-time 3Dimaging [10][11][12]. Nevertheless, due to the requirement of large depth of focus, low NA is typically used in traditional OCT, resulting in relatively low spatial resolution compared with high-NA systems. To ensure high transverse resolution, en face flying spot OCT has been applied for human retinal imaging, which achieves retinal en face images with transverse scanning [13,14]. To be able to realize close to diffraction-limited lateral resolution in OCT retinal imaging, complex hardware adaptive optics (AO) [15][16][17][18][19] or computational AO [20][21][22] would also be needed to correct the aberrations induced by the imperfections of the cornea and lens in the anterior chamber.Full-field OCT (FFOCT) is a kind of time-domain en face parallel OCT that takes images perpendicular to the optical axis without scanning. By using high-NA microscope objectives in a Linnik interferometer, FFOCT is able to achieve standard microscope spatial resolution [23]. With spatially incoherent illumination, cross talk is severely inhibited in FFOCT compared with wide-...

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Introduction to the feature issue on the 25 year anniversary of optical coherence tomography

Abstract: Abstract:The guest editors introduce a feature issue commemorating the 25th anniversary of Optical Coherence Tomography.

Cited by 6 publications

References 22 publications

Longitudinal study of microphthalmia in connexin 50 knockout mice using spectral-domain optical coherence tomography

Longitudinal study of microphthalmia in connexin 50 knockout mice using spectral-domain optical coherence tomography

Deep-Learning-Based Halo-Free White-Light Diffraction Phase Imaging

In vivo high-resolution human retinal imaging with wavefront-correctionless full-field OCT

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