Introduction to the biliary tract, the gallbladder, and gallstones

Gilloteaux, Jacques

doi:10.1002/(sici)1097-0029(19970915)38:6<547::aid-jemt1>3.0.co;2-c

Cited by 10 publications

(15 citation statements)

References 60 publications

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“…Other cholesterol deposits can be fibrillar or curve-shaped accretions in lysosomes (Figs. 15,17) and resemble morphologically the intracellular types detected in cholecystitis (Kouroumalis et al, 1983b;Gilloteaux et al, 1997Gilloteaux et al, ,b, 2003Gilloteaux et al, , 2004 or cholesterolosis (Nevalainen and Laitio, 1972;Koga et al, 1975;Koga, 1985;Gilloteaux et al, 1997Gilloteaux et al, ,a, 2003Gilloteaux et al, , 2004Satoh and Koga, 1997). Some of those can reach more than 2 lm in diameter and are usually oblong in shape.…”

Section: Discussionmentioning

confidence: 84%

“…Having studied and surveyed the same organ in omnivorous types of fish and other vertebrates (Gilloteaux et al, 1995;Gilloteaux, 1997;Oldham-Ott and Gilloteaux, 1997), we were curious as to how this gallbladder would be organized morphologically, considering this species with its exclusively carnivorous and predatory habits. This gallbladder histological architecture corresponds well to the classic pattern as described in most vertebrates (Oldham-Ott and Gilloteaux, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…Following capture, all fishes were kept and transported in running sea water tanks and, less than an hour later, were placed in the laboratory aquaria where, after decapitation, they were dissected following our previous protocol (Oldham-Ott and Gilloteaux, 1997). One specimen was discarded, because it contained a parasitic worm.…”

Section: Methodsmentioning

confidence: 99%

“…During our ongoing laboratory research studies to understand the origin of gallstones in humans, a preliminary, comparative morphological study of the bile tract was undertaken in several vertebrate representatives (Oldham-Ott and Gilloteaux, 1997) as part of a literature review of the chordates verifying the presence or absence of a gallbladder in various species. We also studied various fish gallbladders (Gilloteaux et al, 1995, Oldham-Ott andGilloteaux, 1997) where it was reported that the most complex epithelial morphologies were observed in fishes, probably as adaptations to their respective diets.…”

mentioning

confidence: 99%

“…We also studied various fish gallbladders (Gilloteaux et al, 1995, Oldham-Ott andGilloteaux, 1997) where it was reported that the most complex epithelial morphologies were observed in fishes, probably as adaptations to their respective diets.…”

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confidence: 99%

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The Gallbladder ofUranoscopus ScaberL. (Teleost Perciform Fish) is Lined by Specialized Cholecystocytes

Gilloteaux

Ott

Oldham-Ott

2011

The Anatomical Record

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The gallbladder of Uranoscopus exhibits a mucosal surface layer of simple columnar epithelium composed of specialized cholecystocytes. The apices show storage and mucous secretions, typical microvilli, and very apical projections extending deep into the luminal contents. Many organelles and heterogeneous vesicles of diverse size fill the cytoplasm, including neutral mucins, mitochondria, peroxisomes, lysosomal bodies, and lipid-rich deposits with cholesterol inclusions. The fibromuscular layer shows little blood supply and contains scattered lymph-like walls with minute cholesterol inclusions. The remaining muscular, subserosal, and serosal or adventitial layers of this species do not show any histologic differences to those of other Vertebrates. It was unexpected to find cholesterol inclusions in the fatty deposits of the cholecystocytes, similar to those noted in human cholesterolosis and in some forms of hypercholesterolemia, in this teleostean. In addition, aggregations of mitochondria and anomalous mitochondrial morphologies were found that resemble oncocytoma-like changes. Anat Rec, 294:1890Rec, 294: -1903Rec, 294: , 2011. V V C 2011 WileyLiss, Inc.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The Gallbladder ofUranoscopus ScaberL. (Teleost Perciform Fish) is Lined by Specialized Cholecystocytes

Gilloteaux

Ott

Oldham-Ott

2011

The Anatomical Record

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The Gallbladder of the Electric Ray Torpedo Marmorata Risso Displays Excrescent Cholecystocytes with Merocrine and Apocrine‐Like Secretions

Gilloteaux

Ott

Oldham-Ott

2012

The Anatomical Record

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The gallbladder of Torpedo marmorata exhibits a mucosal surface layer of simple columnar epithelium with very tall cholecystocytes. The apical domain of each cell has few microvilli, but many mucous vesicles that are secreted by exocytosis at the cell apices. The apical regions may also elongate and undergo self-excision while shedding mucus and cell debris into the gallbladder lumen in a manner similar to that described in mammals as a result of sex steroid treatment to induce gallstones and to that found in the cholecystitis associated with cholelithiasis. Numerous small mitochondria, spherical to elongated, are distributed throughout the cells, while the nuclei are often located in the lower third of each cell. In the lower part of the cholecystocytes, large and very densely contrasted lysosomes can be found. All cells are tightly joined by junctional complexes, including long, highly contrasted desmosomes. The fibromuscular layer is made of a loose stroma with a limited muscular component and a poor blood supply. Large diameter blood vessels can only be found in the subserosal layer. It is hypothesized that the obligatorily carnivorous diet of this ureotelic fish has resulted in the evolution of a gallbladder ultrastructure resembling that found in cholecystitis but without the associated cholelithiasis. Anat Rec,

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Abnormalities of the gallbladder, clinical effects

et al. 2008

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The aim of this review of the literature was to present and discuss the anatomical and embryological basis of congenital abnormalities of the gallbladder, based on a case of volvulus. In the rare cases of ectopic gallbladder, diagnosis of a biliary disease could be difficult. In such cases surgery can also be dangerous, especially when it is associated with abnormalities of the intra-hepatic biliary and vascular tree. This study, based on the embryology of the extra hepatic bile duct, focused on the most frequent gallbladder abnormalities to keep them in mind.

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Introduction to the biliary tract, the gallbladder, and gallstones

Cited by 10 publications

References 60 publications

The Gallbladder ofUranoscopus ScaberL. (Teleost Perciform Fish) is Lined by Specialized Cholecystocytes

The Gallbladder ofUranoscopus ScaberL. (Teleost Perciform Fish) is Lined by Specialized Cholecystocytes

The Gallbladder of the Electric Ray Torpedo Marmorata Risso Displays Excrescent Cholecystocytes with Merocrine and Apocrine‐Like Secretions

Abnormalities of the gallbladder, clinical effects

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