Introduction to Stem Cell Therapy

Biehl, Jesse K.; Russell, Brenda

doi:10.1097/jcn.0b013e318197a6a5

Cited by 224 publications

(155 citation statements)

References 26 publications

(24 reference statements)

Supporting

Mentioning

137

Contrasting

Order By: Relevance

“…Unipotent cells have the lowest differentiation potential; they can become only one special cell type. These cells are typically found within their organ and guarantee tissue integrity by serving as cell source to replace aged or injured cells if necessary [31].…”

Section: Controlled Expansion Cultivation and Differentiation Of Mesmentioning

confidence: 99%

See 1 more Smart Citation

Use of Encapsulated Stem Cells to Overcome the Bottleneck of Cell Availability for Cell Therapy Approaches

Freimark¹,

Pino-Grace²,

Pöhl³

et al. 2010

Transfus Med Hemother

View full text Add to dashboard Cite

Nowadays cell-based therapy is rarely in clinical practice because of the limited availability of appropriate cells. To apply cells therapeutically, they must not cause any immune response wherefore mainly autologous cells have been used up to now. The amount of vital cells in patients is limited, and under certain circumstances in highly degenerated tissues no vital cells are left. Moreover, the extraction of these cells is connected with additional surgery; also the expansion in vitro is difficult. Other approaches avoid these problems by using allo-or even xenogenic cells. These cells are more stable concerning their therapeutic behavior and can be produced in stock. To prevent an immune response caused by these cells, cell encapsulation (e.g. with alginate) can be performed. Certain studies showed that encapsulated allo-and xenogenic cells achieve promising results in treatment of several diseases. For such cell therapy approaches, stem cells, particularly mesenchymal stem cells, are an interesting cell source. This review deals on the one hand with the use of encapsulated cells, especially stem cells, in cell therapy and on the other hand with bioreactor systems for the expansion and differentiation of mesenchymal stem cells in reproducible and sufficient amounts for potential clinical use.

show abstract

Section: Controlled Expansion Cultivation and Differentiation Of Mesmentioning

confidence: 99%

“…Cancer cells have the property of self-renewal as well, but they divide in an uncontrolled manner, whereas stem cell division is highly regulated. Therefore, a second requirement for stem cells is their ability to differentiate into a specialized cell type that becomes part of the healthy organism [31].…”

Section: Stem Cells Used For Cell Therapy Approachesmentioning

confidence: 99%

Use of Encapsulated Stem Cells to Overcome the Bottleneck of Cell Availability for Cell Therapy Approaches

Freimark¹,

Pino-Grace²,

Pöhl³

et al. 2010

Transfus Med Hemother

View full text Add to dashboard Cite

show abstract

“…Human embryonic stem cells have great potential for self-renewal and the ability to differentiate into all tissues of the body (except embryonic attachments), 1 forming an important source of material for regenerative medicine and cell therapy. However, the use of embryonic stem cells is limited by ethical and religious conflicts, as well as immunological incompatibility.…”

Section: Introductionmentioning

confidence: 99%

Induced pluripotent stem cells reprogramming: Epigenetics and applications in the regenerative medicine

Gomes

Costa

Santos

et al. 2017

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

Induced pluripotent stem cells (iPSCs) are somatic cells reprogrammed into an embryonic-like pluripotent state by the expression of specific transcription factors. iPSC technology is expected to revolutionize regenerative medicine in the near future. Despite the fact that these cells have the capacity to self-renew, they present low efficiency of reprogramming. Recent studies have demonstrated that the previous somatic epigenetic signature is a limiting factor in iPSC performance. Indeed, the process of effective reprogramming involves a complete remodeling of the existing somatic epigenetic memory, followed by the establishment of a "new epigenetic signature" that complies with the new type of cell to be differentiated. Therefore, further investigations of epigenetic modifications associated with iPSC reprogramming are required in an attempt to improve their self-renew capacity and potency, as well as their application in regenerative medicine, with a new strategy to reduce the damage in degenerative diseases. Our review aimed to summarize the most recent findings on epigenetics and iPSC, focusing on DNA methylation, histone modifications and microRNAs, highlighting their potential in translating cell therapy into clinics.

show abstract

“…Stem cells have the ability to build every tissue in the animal body. Therefore, Stem cells have great potential for future therapeutic uses in tissue regeneration and repair [10].…”

Section: Introductionmentioning

confidence: 99%