Introduction to Radiation Biology When Treating Hyperproliferative Benign Diseases

Rödel, Franz; Seegenschmiedt, M. Heinrich

doi:10.1007/978-3-319-32199-8_45

Cited by 1 publication

(3 citation statements)

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“…This adds to the concept of treating hyperproliferative benign diseases by low and moderate doses of IR [144]. NK cells play a significant role in antitumor reactions triggered by ionising radiation plus hyperthermia [145].…”

Section: Links Of Non-targeted Effects To Immunological (Inflammatorymentioning

confidence: 99%

“…On the basis of clonogenic assays on different glioblastoma cell lines, it could be shown that fractionated RT stimulates the induction of glioblastoma cell death forms with immunogenic potential [168]. It was also recognized that RT can also exert beneficial effects on non-malignant diseases [144,247] and [248][249][250][251][252][253][254]. Indeed, several positive effects of low doses of IR were also reported in patients with benign painful elbow or shoulder syndrome, achillodynia, calcaneodynia, possibly due to anti-inflammatory and immune modulating IR effects [248][249][250][251][252][253][254][255].…”

Section: Involvement Of Non-targeted and Immunological Effects (Inflamentioning

confidence: 99%

“…Non-targeted and systemic effects play a significant role and also DNA damage and repair are involved. The involvement of immunological processes in successful radiotherapeutic treatments of cancer starts to be well documented [129,140,141,144].…”

Section: Progress In the Understanding Of Radiation Induced Effects Omentioning

confidence: 99%

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Progress in low dose health risk research

Averbeck

Salomaa

Bouffler

et al. 2018

Mutation Research/Reviews in Mutation Research

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People are more often exposed to low as opposed to high doses of ionising radiation (IR). Knowledge on the health risks associated with exposures to ionising radiation above 100 mGy is quite well established, while lower dose risks are inferred from higher level exposure information (ICRP). The health risk assessments are mainly based on epidemiological data derived from the atomic bombing of Hiroshima and Nagasaki, medical exposure studies and follow-up studies after nuclear accidents. For the estimation of long-term stochastic radiation health effects (such as cancer) and radiation protection purposes, a linear non-threshold (LNT) model is applied. However, the general validity of the LNT hypothesis for extrapolations from effects of high to low doses (<100 mGy) and low dose-rates (<6 mGy/h) has been questioned as epidemiological studies are statistically limited at low doses and unable to evaluate low dose and low dose-rate health risks (UNSCEAR). Thus, uncertainties on health risks need to be clarified with the help of mechanistic studies. The European Network of Excellence DoReMi (2010-2016) was designed to address some of the existing uncertainties and to identify research lines that are likely to be most informative for low dose risk assessment. The present review reports the results obtained from studies addressing the induction of cancer and non-cancer effects by low dose IR as well as on individual radiation sensitivity. It is shown that low dose and low dose-rate effects are the result of complex network responses including genetic, epigenetic, metabolic and immunological regulation. Evidence is provided for the existence of nonlinear biological responses in the low and medium dose range as well as effects other than the classical DNA damage. Such effects may have a bearing on the quantitative and qualitative judgements on health effects induced by low dose radiations.

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Section: Links Of Non-targeted Effects To Immunological (Inflammatorymentioning

confidence: 99%