Introduction to Neural Stem Cells

Kornblum, Harley I.

doi:10.1161/01.str.0000255757.12198.0f

Cited by 84 publications

(45 citation statements)

References 76 publications

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“…Among the candidates, cells that have proliferation and differentiation potentials higher than matured cells, so-called stem cells, are promising from the viewpoint of cell-based (Leo & Grande 2006;Docheva et al 2007;Fibbe et al 2007;Picinich et al 2007;Shanti et al 2007). In addition, neural stem cells (Hsu et al 2007;Kornblum 2007) However, one of the problems is the shortage of cells clinically available. Therefore, it is necessary to develop a technology or methodology for the preparation of a large number of stem cells of high quality.…”

Section: Fundamental Biomaterials Technology and Methodology For Tissumentioning

confidence: 99%

Biomaterial technology for tissue engineering applications

Tabata

2009

J. R. Soc. Interface.

297

197

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Tissue engineering is a newly emerging biomedical technology and methodology to assist and accelerate the regeneration and repairing of defective and damaged tissues based on the natural healing potentials of patients themselves. For the new therapeutic strategy, it is indispensable to provide cells with a local environment that enhances and regulates their proliferation and differentiation for cell-based tissue regeneration. Biomaterial technology plays an important role in the creation of this cell environment. For example, the biomaterial scaffolds and the drug delivery system (DDS) of biosignalling molecules have been investigated to enhance the proliferation and differentiation of cell potential for tissue regeneration. In addition, the scaffold and DDS technologies contribute to develop the basic research of stem cell biology and medicine as well as obtain a large number of cells with a high quality for cell transplantation therapy. A technology to genetically engineer cells for their functional manipulation is also useful for cell research and therapy. Several examples of tissue engineering applications with the cell scaffold and DDS of growth factors and genes are introduced to emphasize the significance of biomaterial technology in new therapeutic and research fields.

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Section: Fundamental Biomaterials Technology and Methodology For Tissumentioning

confidence: 99%

Biomaterial technology for tissue engineering applications

Tabata

2009

J. R. Soc. Interface.

297

197

View full text Add to dashboard Cite

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“…The advantages of adult neural stem cells are in the lack of ethical concerns associated with their use, their ability to be cultured, their potential for autologous transplantation, and their predetermined tendency to differentiate into cells of the neural lineage [62][63][64][65]. The disadvantages associated with adult neural stem cells are in the limited number of available cells, difficulty in expansion, cell senescence after several passages, paucity of clinical trial data, and their tendency to form tumors [62,66]. These advantages and disadvantages should be considered within the framework of the relationships between adult NSCs and their niche, their cell compartment, and niche factors influencing their behavior [66,67].…”

Section: Sources Of Stem Cells -Advantages Disadvantages and Other mentioning

confidence: 99%

“…The disadvantages associated with adult neural stem cells are in the limited number of available cells, difficulty in expansion, cell senescence after several passages, paucity of clinical trial data, and their tendency to form tumors [62,66]. These advantages and disadvantages should be considered within the framework of the relationships between adult NSCs and their niche, their cell compartment, and niche factors influencing their behavior [66,67]. A brief synopsis of advantages and disadvantages of ASCs for the treatment of neurodegenerative diseases is included in Table 3.…”

Section: Sources Of Stem Cells -Advantages Disadvantages and Other mentioning

confidence: 99%

Stem Cell Therapy for Brain Tumors

Aleynik

Rameshwar

2015

IJTS

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Glioblastoma multiforme (GBM), the most common and lethal brain cancer, prognosis remains bleak with a median survival of about 15 months despite maximal surgical resection, radiotherapy, and temozolomide treatment. The difficulty associated with safely and effectively delivering therapeutics across the blood brain barrier (BBB) is a major challenge towards GBM treatment. Ongoing research and clinical trials, including attempts to deliver therapeutics within stem cells present possible solutions. The relationships between brain cancer pathology, stem cell properties, therapeutic advantages and disadvantages of various stem cell types, drug delivery methods, cancer stem cells, gene therapy, anti-cancer vaccines, chimeric antigen receptor therapies, and combination therapies are discussed.

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“…Basicamente, essas estruturas são formadas por CTN multipotentes e progenitores neurais com desenvolvimento mais comprometido 9,18,19 . Alguns estudos têm demonstrado que astrócitos da zona subventricular que expressam uma proteína glial também podem ser considerados como CTN 20 .…”

Section: Transplante De Células-tronco Neuraisunclassified

Use of stem cells in perinatal asphyxia: from bench to bedside

Paula¹,

Greggio²,

Costa³

2010

J Pediatr (Rio J)

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Objectives: To present recent scientific evidence on the effects of stem cell transplantation in animal models of neonatal hypoxic-ischemic brain injury and address the translational relevance of cell therapy for clinical application in this context. Sources:The PubMed and Scopus databases were used to select articles. The selection criterion was the specificity of articles regarding the subject studied, preferably articles published from 2000 onward. We also reviewed classic articles from previous years that were applicable to this review. Summary of the findings:Stem cells from different exogenous sources may exhibit neuroprotective properties in experimental models of neonatal hypoxia-ischemia. In most animal experiments, the morphological and functional benefits observed were independent of neural differentiation, suggesting associated mechanisms of action, such as the release of trophic factors and inflammatory modulation. Conclusions:Based on the experimental studies analyzed, cell therapy may become a promising therapeutic approach in the treatment of children with hypoxic-ischemic encephalopathy. However, further studies are warranted to elucidate potential mechanisms of action of these cells and to define safe and effective clinical strategies.J Pediatr (Rio J). 2010;86(6):451-464: Hypoxic-ischemic encephalopathy, stem cells, asphyxia, cell therapy. ResumoObjetivos: Apresentar evidências científicas recentes sobre os efeitos do transplante com células-tronco em modelos animais de lesão cerebral hipóxico-isquêmica neonatal e abordar os aspectos translacionais relevantes à aplicação clínica da terapia celular nesse contexto. Fonte dos dados:Para a seleção dos artigos, utilizou-se a base de dados PubMed e Scopus. O critério de seleção de artigos foi a especificidade em relação ao tema estudado, preferencialmente a partir do ano de 2000. Também foram revisados artigos clássicos de anos anteriores que se aplicavam ao propósito desta revisão. Síntese dos dados:Células-tronco de diferentes fontes exógenas podem exibir propriedades neuroprotetoras em modelos experimentais de hipóxia-isquemia neonatal. Na maioria dos experimentos animais, os benefícios morfológicos e funcionais observados foram independentes da diferenciação neural, sugerindo mecanismos de ação associados, tais como a liberação de fatores tróficos e a modulação inflamatória. Conclusões:Baseado nos estudos experimentais analisados, a terapia celular pode tornar-se uma promissora abordagem terapêutica no tratamento de crianças com encefalopatia hipóxico-isquêmica. No entanto, estudos adicionais necessitam ser realizados a fim de elucidar os possíveis mecanismos de ação dessas células e definir estratégias clínicas seguras e efetivas.J Pediatr (Rio J). 2010;86(6):451-464: Encefalopatia hipóxico-isquêmica, células-tronco, asfixia, terapia celular.

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Introduction to Neural Stem Cells

Cited by 84 publications

References 76 publications

Biomaterial technology for tissue engineering applications

Biomaterial technology for tissue engineering applications

Stem Cell Therapy for Brain Tumors

Use of stem cells in perinatal asphyxia: from bench to bedside

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