Pathogens with multidrug resistance have recently been responsible for widespread disease, fatalities, and economic distress. A nanomaterial with antibacterial characteristics is used to reduce the infection’s resistance. Metal-oxide nanocomposites are nanomaterials that exhibit outstanding physical and chemical characteristics. They are prime candidates for innovative functional materials with antimicrobial activity as one of their main uses. This review will summarize the current progress on the antimicrobial activity of metal-oxide nanocomposite, including widely recognized research outputs and recent findings, as these materials can overcome the limitation of the individual material due to their utterly different properties from the single materials. Additionally, it describes several metal-oxide nanocomposites that are produced using various methods for the application of antimicrobial activity, as well as the variables that can affect such activities and the main inhabitation mechanisms of this materials.