Introduction to Multimodality Intravascular Imaging

Chen, Zhongping; Zhou, Qifa

doi:10.1007/978-981-10-6307-7_1

Cited by 2 publications

(2 citation statements)

References 83 publications

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“…In this case, fluorescence imaging provided the surface projection of the targeted Cetuximab-IRDye800 agent, PA imaging showed the depth resolved optical absorption contrast from the IRDye800 and surrounding vasculature, and ultrasound imaging revealed the underlying tissue anatomy. For imaging atherosclerosis, a cardiovascular disease characterized by the accumulation of lipid plaques and several fibrous and cellular constituents, intravascular ultrasound (IVUS) and optical coherence tomography (OCT) technologies are commonly used in the clinics [16][17][18]. Recently, intravascular PA (IVPA) is also being actively studied for mapping deep tissue atherosclerosis based on high optical absorption contrast of plaque lipids in the NIR-IIb (1.5 μm-1.7 μm) optical window [19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

A Transparent Ultrasound Array for Real-Time Optical, Ultrasound, and Photoacoustic Imaging

et al. 2022

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Objective and Impact Statement. Simultaneous imaging of ultrasound and optical contrasts can help map structural, functional, and molecular biomarkers inside living subjects with high spatial resolution. There is a need to develop a platform to facilitate this multimodal imaging capability to improve diagnostic sensitivity and specificity. Introduction. Currently, combining ultrasound, photoacoustic, and optical imaging modalities is challenging because conventional ultrasound transducer arrays are optically opaque. As a result, complex geometries are used to coalign both optical and ultrasound waves in the same field of view. Methods. One elegant solution is to make the ultrasound transducer transparent to light. Here, we demonstrate a novel transparent ultrasound transducer (TUT) linear array fabricated using a transparent lithium niobate piezoelectric material for real-time multimodal imaging. Results. The TUT-array consists of 64 elements and centered at ~6 MHz frequency. We demonstrate a quad-mode ultrasound, Doppler ultrasound, photoacoustic, and fluorescence imaging in real-time using the TUT-array directly coupled to the tissue mimicking phantoms. Conclusion. The TUT-array successfully showed a multimodal imaging capability and has potential applications in diagnosing cancer, neurological, and vascular diseases, including image-guided endoscopy and wearable imaging.

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Section: Introductionmentioning

confidence: 99%

A Transparent Ultrasound Array for Real-Time Optical, Ultrasound, and Photoacoustic Imaging

et al. 2022

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show abstract

“…In this case, fluorescence imaging provided the surface projection of the targeted Cetuximab-IRDye800 agent, PA imaging showed the depth resolved optical absorption contrast from the IRDye800 and surrounding vasculature, and ultrasound imaging revealed the underlying tissue anatomy. For imaging atherosclerosis, a cardiovascular disease characterized by the accumulation of lipid plaques and several fibrous and cellular constituents, intravascular ultrasound (IVUS) and optical coherence tomography (OCT) technologies are commonly used in the clinics [13][14][15]. Recently, intravascular PA (IVPA) is also being actively studied for mapping deep tissue atherosclerosis based on high optical absorption contrast of plaque lipids in the NIR-IIb (1.5 µm -1.7 µm) optical window [16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

A Transparent Ultrasound Array for Real-time Optical, Ultrasound and Photoacoustic Imaging

Chen

Agrawal

Osman

et al. 2021

Preprint

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Objective and Impact StatementSimultaneous imaging of ultrasound and optical contrasts can help map structural, functional and molecular biomarkers inside living subjects with high spatial resolution. There is a need to develop a platform to facilitate this multimodal imaging capability to improve diagnostic sensitivity and specificity.IntroductionCurrently, combining ultrasound, photoacoustic and optical imaging modalities is challenging because con-ventional ultrasound transducer arrays are optically opaque. As a result, complex geometries are used to co-align both optical and ultrasound waves in the same field of view.MethodsOne elegant solution is to make the ultrasound transducer transparent to light. Here, we demonstrate a novel transparent ultrasound transducer (TUT) liner array fabricated using a transparent lithium niobate piezoelectric material for real-time multimodal imaging.ResultsThe TUT array consisted of 64 elements and centered at ∼ 6 MHz frequency. We demonstrate a quad-mode ultrasound, Doppler ultrasound, photoacoustic and fluorescence imaging in real-time using the TUT array directly coupled to the tissue mimicking phantoms.ConclusionThe TUT array successfully showed a multimodal imaging capability, and has potential applications in diagnosing cancer, neuro and vascular diseases, including image-guided endoscopy and wearable imaging.

show abstract

Introduction to Multimodality Intravascular Imaging

Cited by 2 publications

References 83 publications

A Transparent Ultrasound Array for Real-Time Optical, Ultrasound, and Photoacoustic Imaging

A Transparent Ultrasound Array for Real-Time Optical, Ultrasound, and Photoacoustic Imaging

A Transparent Ultrasound Array for Real-time Optical, Ultrasound and Photoacoustic Imaging

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