Careful consideration of the preform shape is essential when designing a forging process. A high-quality forging process must promote process-related grain re nement, and an unbroken grain ow devoid of cavities or folding besides minimizing the amount of generated ash while achieving a complete die ll.The desired forged part properties can be obtained by optimizing the preform shape. However, threedimensional shape optimization presents challenges in design generation and design evaluation due to the resource-intensive demands of each task. To address these challenges, we propose a multi-objective optimization framework consisting of a parametric computer-aided design (CAD) model for shape generation, data-driven models for shape evaluation, and a multi-objective evolutionary optimization algorithm to search the design space effectively. This computational framework is used to evolve an optimal preform shape which was ultimately cast using permanent mould casting (PMC) and then hot forged under elevated temperature conditions. We compared the forging outcome of the optimal preform with a baseline cylindrical billet which was produced according to the same sequence of manufacturing steps. Comparative analysis of the laboratory-scale forging results revealed that the cast-preform and cast-billet produced about 6% and 12% ash material, respectively. Quasi-static tensile and stresscontrolled cyclic tests were also conducted to evaluate mechanical properties. While comparable yield and ultimate tensile strengths were observed in both forgings, a signi cant increase in fracture strain was observed in the preform forging, suggesting improved toughness. In general, the forging outcome of the optimized preform proved to be superior to the billet forging.