Introduction to Chemical Ligation Reactions

Rosa, Lucía De; Romanelli, Alessandra; D’Andrea, Luca Domenico

doi:10.1002/9781119044116.ch1

Cited by 1 publication

(1 citation statement)

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“…Various techniques for anchoring a chelating agent to a molecule of interest are described in the literature, each of them requiring the presence of a dedicated reactive group on the chelator to undergo this functionalization [37,38]. In the AAZTA structure, the methyl group on the sp 3 central carbon atom of the propylene endocyclic moiety is particularly suitable for derivatization as it is exocyclic and not involved in metal ion complexation.…”

Section: Aazta Modulations To Obtain Bifunctional Chelating Agents (Bca)mentioning

confidence: 99%

AAZTA-Derived Chelators for the Design of Innovative Radiopharmaceuticals with Theranostic Applications

et al. 2022

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With the development of 68Ga and 177Lu radiochemistry, theranostic approaches in modern nuclear medicine enabling patient-centered personalized medicine applications have been growing in the last decade. In conjunction with the search for new relevant molecular targets, the design of innovative chelating agents to easily form stable complexes with various radiometals for theranostic applications has gained evident momentum. Initially conceived for magnetic resonance imaging applications, the chelating agent AAZTA features a mesocyclic seven-membered diazepane ring, conferring some of the properties of both acyclic and macrocyclic chelating agents. Described in the early 2000s, AAZTA and its derivatives exhibited interesting properties once complexed with metals and radiometals, combining a fast kinetic of formation with a slow kinetic of dissociation. Importantly, the extremely short coordination reaction times allowed by AAZTA derivatives were particularly suitable for short half-life radioelements (i.e., 68Ga). In view of these particular characteristics, the scope of this review is to provide a survey on the design, synthesis, and applications in the nuclear medicine/radiopharmacy field of AAZTA-derived chelators.

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Section: Aazta Modulations To Obtain Bifunctional Chelating Agents (Bca)mentioning

confidence: 99%