Introduction to Cancer Biology

Paulmurugan, Ramasamy

doi:10.1142/9789814293686_0001

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…When this proliferation is allowed to continue and spread, cancer develops. Almost 90% of cancer-related deaths are due to tumor spreading-a process called metastasis [2]. Cancer genetics can predict the networks and pathways that contribute to tumor development and the mechanism of cancer genes promoting tumor evolution [3].…”

Section: Introductionmentioning

confidence: 99%

Effect of SMAD4 gene polymorphism on breast cancer risk in Bangladeshi women

Rahman

Islam

Apu

et al. 2023

Beni-Suef Univ J Basic Appl Sci

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Background Breast cancer, one of the most prevalent cancer types among women worldwide as well as in Bangladesh, is the leading cause of cancer death in women throughout the globe. The risk of breast cancer development was found to be associated with genetic polymorphism according to several studies. As a convenient prognostic marker, a biomarker helps to identify disease progression, can lead to an effective therapeutic strategy, development of prognostic marker is very important for any cancer to initiate treatment strategy early to increase the possibility of the success rate of the treatment along with reduction of the treatment cost. This study aims to establish the correlation between polymorphism of SMAD4 rs10502913 and risk of breast cancer development in Bangladeshi women. This study was conducted on 70 breast cancer patients and 60 healthy volunteers through blood sample collection followed by DNA separation between the intervals of August 2019–October 2019. The collected DNA sample was arranged for the RFLP analysis of a PCR amplified fragments followed by gel electrophoresis. The obtained data was analyzed by structured multinomial logistic regression model. Results Obtained different fragment size after gel electrophoresis indicated different genotypes in this experiment. Our findings demonstrated that mutant homozygous A/A genotype, plays a significant role in breast cancer development among Bangladeshi women (P = 0.006, OR = 4.9626, 95% CI = 1.9980–12.3261) compared to the reference homozygous G/G genotype. Moreover, heterozygous G/A genotype was also found to be significantly associated with the risk of breast cancer development (P = 0.0252, OR = 2.6574, CI = 1.1295–6.2525). Considering the A/A genotype and G/A genotype combined, it also indicates a strong association of breast cancer development in Bangladeshi women (P = 0.008, OR = 3.5630, CI = 1.6907–7.5068). Conclusion Our study indicated a novel association between SMAD4 (rs10502913) polymorphism and increased risk of breast cancer development in Bangladeshi women.

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Section: Introductionmentioning

confidence: 99%

Effect of SMAD4 gene polymorphism on breast cancer risk in Bangladeshi women

Rahman

Islam

Apu

et al. 2023

Beni-Suef Univ J Basic Appl Sci

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“…Cancer is a disease recognized by uncontrolled cell division to make a malignant tumor that can invade cells and tissues in a process called metastasis . This is the second main cause of death worldwide, causing 9.6 million deaths. , Cancer has various types, and liver cancer is the fourth cause of death followed by breast cancer in the United States .…”

Section: Introductionmentioning

confidence: 99%

Bioactivity Studies of Hesperidin and XAV939

et al. 2021

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The present work aimed to evaluate the reactivity of natural bioflavonoid hesperidin (HSP) and synthetically derived XAV939 (XAV) against human hepatocellular carcinoma (HepG2), human breast cancer (MDA-MB231) cancer cell lines, and related molecular and pathological profiles. Data recorded revealed that the cytotoxic potential of the tested products was found to be cell type-and concentration-dependent. The halfmaximal inhibitory concentration (IC 50 ) value of the HSP-XAV mixture against MDA-MB231 was significantly decreased in the case of using the HSP-XAV mixture against the HepG2 cell line. Also, there was a significant upregulation of the phosphotumor suppressor protein gene (P53) and proapoptotic genes such as B-cell lymphomaassociated X-protein (Bax, CK, and Caspase-3), while antiapoptotic gene B-cell lymphoma (Bcl-2) was significantly downregulated compared with the untreated cell control. The cell cycle analysis demonstrated that DNA accumulation was detected mainly during the G2/ M phase of the cell cycle accompanied with the elevated reactive oxygen species level in the treatment of HepG2 and MDA-MB231 cell lines by the HSP-XAV mixture, more significantly than that in the case of cell control. Finally, our finding suggests that both HSP and XAV939 and their mixture may offer an alternative in human liver and breast cancer therapy.

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“…El cáncer se ha caracterizado como un proceso complejo de múltiples enfermedades que pueden afectar cualquier órgano del cuerpo; involucra diversos cambios dinámicos en el genoma y se establece cuando las células son incapaces de formar estructuras funcionales estables; lo que promueve una división descontrolada (Floor, Dumont, Maenhaut, & Raspe, 2012). La evolución progresiva de modificaciones bioquímicas y biológicas a las que se enfrenta la transformación de la célula normal a un estado neoplásico, radica en la adquisición sin limite de capacidades autónomas de replicación, proliferación, invasión y sobrevivencia, por sólo mencionar algunas (González Angulo et al; 2011 y (Paulmurugan, 2012). La dinámica de estas modificaciones incipientes en las células junto con su microambiente, orquestan de manera conjunta la adquisición de los rasgos necesarios para el establecimiento de la tumorigénesis y a la vez generar eventos cruciales para su mantenimiento y sobrevivencia (Lorusso & Rüegg, 2008).…”

Section: Biología Del Cáncerunclassified

Análisis molecular del tipo de muerte celular inducido por la terapia coadyudante: metformina y el oxamato de sodio como inhibidores de la vía mTOR y la glucólisis en un modelo celular triple negativo de cáncer de mama

Castillo

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De manera particular agradezco al Dr. Carlos Pérez-Plasencia por brindarme un espacio en su grupo de trabajo y proporcionarme todas las herramientas necesarias para concretar exitosamente cada experimento y por todas sus exigencias que lograron hacerme crecer profesionalmente cada día. A la Dra. Nadia J. Jacobo Herrera por su apoyo, asesoría y confianza incondicional; quien siempre estuvo pendiente de mí y proporcionarme todo lo necesario para culminar exitosamente éste proyecto. Al Dr. Luis E. Gómez Quiroz quien siempre estuvo pendiente del desarrollo de éste proyecto; agradezco infinitamente su asesoria, sus consejos y su dedicación en mi formación académica. Al Dr. R. Eduardo López Urrutia por su asesoría y apoyo durante el escrito de esta tesis y en la fase experimental.

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Introduction to Cancer Biology

Cited by 5 publications

References 25 publications

Effect of SMAD4 gene polymorphism on breast cancer risk in Bangladeshi women

Effect of SMAD4 gene polymorphism on breast cancer risk in Bangladeshi women

Bioactivity Studies of Hesperidin and XAV939

Análisis molecular del tipo de muerte celular inducido por la terapia coadyudante: metformina y el oxamato de sodio como inhibidores de la vía mTOR y la glucólisis en un modelo celular triple negativo de cáncer de mama

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