Introduction to biomedical polymers and biocompatibility

Poole-Warren, Laura A.; Patton, Alexander J.

doi:10.1016/b978-1-78242-105-4.00001-8

Cited by 16 publications

(12 citation statements)

References 46 publications

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“…One of the main drawback of the use of polysaccharides in the nanomedicine field is its degradation (oxidation) characteristics at high temperatures (above their melting point) which are often required in industrial processes. Besides, most of the polysaccharides are soluble in water, which limits their application in some fields of nanomedicine, such as tissue engineering [ 182 , 183 ]. However, techniques such as crosslinking of the polymer chains have been employed in order to guarantee stability of the polysaccharide chains, guaranteeing them stability in aqueous environments [ 182 , 183 ].…”

Section: Drug Designing and Drug Delivery Process And Mechanismmentioning

confidence: 99%

Nano based drug delivery systems: recent developments and future prospects

et al. 2018

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Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines. Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc.) in the treatment of various diseases. The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (e.g., natural products) and selective diagnosis through disease marker molecules. The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed. In addition, we have included information regarding the trends and perspectives in nanomedicine area.

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Section: Drug Designing and Drug Delivery Process And Mechanismmentioning

confidence: 99%

Nano based drug delivery systems: recent developments and future prospects

et al. 2018

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“…The most common polypeptides used in biomedicine are collagen and gelatin ( Table 1 ). However, known limitations of natural polymers include their very low dimensional stability, susceptibility to immunogenic responses, possibility of pathogen transmission and high batch-to-batch variability [ 12 , 13 ]. For this reason, biodegradable synthetic polymers are frequently employed as alternatives.…”

Section: Polymers Natural/syntheticmentioning

confidence: 99%

Recent Advances in Fiber–Hydrogel Composites for Wound Healing and Drug Delivery Systems

2021

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In the last decades, much research has been done to fasten wound healing and target-direct drug delivery. Hydrogel-based scaffolds have been a recurrent solution in both cases, with some reaching already the market, even though their mechanical stability remains a challenge. To overcome this limitation, reinforcement of hydrogels with fibers has been explored. The structural resemblance of fiber–hydrogel composites to natural tissues has been a driving force for the optimization and exploration of these systems in biomedicine. Indeed, the combination of hydrogel-forming techniques and fiber spinning approaches has been crucial in the development of scaffolding systems with improved mechanical strength and medicinal properties. In this review, a comprehensive overview of the recently developed fiber–hydrogel composite strategies for wound healing and drug delivery is provided. The methodologies employed in fiber and hydrogel formation are also highlighted, together with the most compatible polymer combinations, as well as drug incorporation approaches creating stimuli-sensitive and triggered drug release towards an enhanced host response.

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“…Biodegradable polymers, such as polycaprolactone (PCL), poly(L-lactic acid) (PLA), poly(glycolide) (PGA) (properties of the named polymers are summarized in Figure 7), and their copolymer poly(L-lactide- co -glycolide) (PLGA), have attracted much attention due to their excellent mechanical properties. These polymers can be used in biomedical applications, such as surgical sutures, drug carriers, tissue—engineering scaffolds, implants for interior bone fixation, and other temporary medical devices [130,131,132,133,134]. The polymers break down into basic components that are not toxic for the body.…”

Section: Biliary Stentmentioning

confidence: 99%

Biocompatible Polymer Materials with Antimicrobial Properties for Preparation of Stents

et al. 2019

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Biodegradable polymers are promising materials for use in medical applications such as stents. Their properties are comparable to commercially available resistant metal and polymeric stents, which have several major problems, such as stent migration and stent clogging due to microbial biofilm. Consequently, conventional stents have to be removed operatively from the patient’s body, which presents a number of complications and can also endanger the patient’s life. Biodegradable stents disintegrate into basic substances that decompose in the human body, and no surgery is required. This review focuses on the specific use of stents in the human body, the problems of microbial biofilm, and possibilities of preventing microbial growth by modifying polymers with antimicrobial agents.

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Introduction to biomedical polymers and biocompatibility

Cited by 16 publications

References 46 publications

Nano based drug delivery systems: recent developments and future prospects

Nano based drug delivery systems: recent developments and future prospects

Recent Advances in Fiber–Hydrogel Composites for Wound Healing and Drug Delivery Systems

Biocompatible Polymer Materials with Antimicrobial Properties for Preparation of Stents

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