Introduction to biodegradable polylactic acid ureteral stent application for treatment of ureteral war injury

Abstract

These authors contributed equally to the study the other side was debrided and sutured without stenting.• Both IVP and radioactive renography were performed 40, 80 and 120 days postoperatively. The operability and effectiveness of the biodegradable ureteral stent were studied thereafter. RESULTS• In Group A, hydronephrosis and hydroureter occurred and worsened postoperatively on the wounded sides in all nine beagles. The ratio of the renal partial concentration indices (RPCI) between the kidneys (unwounded side : wounded side) increased.• The ratio of the kidney washout half-time between the kidneys (unwounded side : wounded side) decreased. In Group B, neither hydronephrosis nor hydroureter was found postoperatively in the stented ureters but both occurred in the unstented ureters in all nine beagles.• The ratio of RPCI between kidneys (stented side : unstented side) increased whereas the kidney washout half-time ratio between the stented and unstented sides decreased. Differences were significant. CONCLUSION• In Group A, the new canine model for firearm fragment wounds was tested and proved to be operable and effective. In Group B, hydronephrosis and hydroureter were effectively prevented in ureters by biodegradable stent placement compared with the non-stented ureters where hydronephrosis and hydroureter occurred. The renal concentration capacity was effectively protected and the half-time of kidney washout was shortened.

Properties and medical applications of polylactic acid: A review

“…The NB encased the implant and thus enhanced biological fixation of the biomaterials to the host bone (HB) [71,72] surgical sutures, healing dental extraction wounds, and preventing postoperative adhesions. Li et al [74] evaluated the efficacy and feasibility of PLA ureteral stents for the treatment of ureteral war injuries. The stents made of PLA were reliable in the treatment of ureteral war injuries where PLA stents were degraded so that they were removed from the body.…”

Tissue engineering of ureteral grafts by seeding urothelial differentiated hADSCs onto biodegradable ureteral scaffolds

“…They possess good mechanical properties, low toxicity and predictable biodegradation kinetics 28. In previous study, our group had confirmed the good biocompatibility, biodegradable and good mechanicalness of the PLA scaffold in the study of ureteral and urethral engineering in the wound injury model 29–32. According to our previous work, it takes approximately 10 weeks for the hydrolytic degradation process of the stent in canine urine at 37°C, the biodegradable stent finally degraded to a sand‐like substance 32…”

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“…Li et al, (2011) analyzed the capability and contingency of PLA ureteral stents used for treating the ureteral injuries. PLA stents are degradable type that later can be removed from human body 25 . Consequently, PLA stents displayed a promising future in the treatment of ureteral injuries.…”