Introduction to, and classification of, the systemic vasculitides

Luqmani, Raashid; Robinson, Helen M.

doi:10.1053/berh.2001.0139

Cited by 18 publications

(12 citation statements)

References 50 publications

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“…The concordance of these two systems for HSP was very low, with only 12 out of 71 patients fulfilling criteria for both classifications. Furthermore, according to the ACR criteria, HSP can easily be misclassified as other forms of vasculitis [8].…”

Section: Henoch-schönlein Purpuramentioning

confidence: 99%

“…To define a disease is to identify the essential elements of the disease that are present in all cases [8]. In Chapel Hill, an international group led by rheumatologists, nephrologists and pathologists gathered to reach consensus in constructing root definitions for vasculitides [2].…”

Section: Introductionmentioning

confidence: 99%

“…Another limitation of CHCC in adults is with the term polyarteritis nodosa (PAN). With polyarteritis the CHCC restricts the definition of PAN to a disease involving medium or small arteries and excludes smaller vessel involvement [2,8]. Again, in a number of adult series it has been shown that this elimination poses problems since adult patients with classical PAN occasionally do have small arterial involvement as well.…”

Section: Introductionmentioning

confidence: 99%

“…The same is true in children. PAN, as restricted according to CHCC, may therefore be exceedingly rare [8]. Clinical diagnosis of PAN depends on the findings at biopsy and/or arteriography, which in certain settings may not be possible.…”

Section: Introductionmentioning

confidence: 99%

“…In the case of Takayasu arteritis, patients with early symptoms may not meet the CHCC or the ACR criteria [8]. An elevated ESR is not included in either criteria although it is very useful in the diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Problems in classifying vasculitis in children

Özen

2005

Pediatr Nephrol

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Vasculitis is inflammation of blood vessels, which may also affect the arteries of the kidney. The definition and classification of vasculitides derive from the Chapel Hill nomenclature criteria (CHCC) and American College of Rheumatology (ACR) criteria, respectively. These criteria are not perfect, and adult literature refers to problems with misclassification and a low concordance between the two criteria. The problems associated with defining a child patient according to these criteria are even more apparent, since both sets of criteria have been based on adult data alone and have never been validated in children. When classifying their patients as having polyarteritis, paediatricians do not keep strictly to the CHCC or ACR criteria. A recent series has shown that the microscopic polyarteritis associated with MPO-ANCA and the HBs associated with classic polyarteritis nodosa are rarer in children than in adults. Paediatricians should revise the existing criteria based on registries and international consensus in the field.

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Section: Henoch-schönlein Purpuramentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Problems in classifying vasculitis in children

Özen

2005

Pediatr Nephrol

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Screening of serum samples from Wegener's granulomatosis patients using antibody microarrays

Olle

Deogracias

Messamore

et al. 2007

Proteomics Clinical Apps

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Wegener's Granulomatosis (WG) is an idiopathic granulomatosis autoimmune vasculitis that primarily affects small vessels and is associated with glomerulonephritis and pulmonary granulomatous vasculitis. Anti-neutrophil cytoplasmic auto-antibodies (cANCA) against proteinase-3 are used to identify WG, but ANCA titers are not present in some patients with the localized disease. The objective of this study was to develop an antibody array to help identify protein expression patterns in serum from patients with WG as compared to normals. The arrays were tested for limits of detection, background, and cross reactivity using standard proteins. The arrays were hybridized with either normal patient serum (n = 30) or with serum samples from a population of WG patients (n = 26) that were age and sex matched. Data analysis and curve fitting of the standard dilution series calculated r(2) values and determined a sensitivity of <50 pg/mL for the majority of proteins. A total of 24 proteins were assessed. Several statistically significant increases (p<0.05) were seen in the expression of: angiotensin converting enzyme-I, IFN-γ, IL-8, s-ICAM-1 and s-VCAM in WG patients as compared to controls. Utilizing the antibody microarray technology has led to the identification of potential biomarkers of vascular injury in the serum of WG patients.

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A new international classification of childhood vasculitis

Dillon¹,

Özen

2006

Pediatr Nephrol

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There has been, for many years, a need for an acceptable classification of childhood vasculitis as well as criteria for classifying specific sub-categories of vasculitic disease affecting the young. Hitherto, there has been, with certain exceptions, much reliance on adult classification systems and criteria that have not proved entirely satisfactory. A recent International Consensus Conference held in Vienna in June 2005 attempted to rectify this state of affairs. It resulted in a new proposal for childhood vasculitis classification and proposals of classification criteria for several important categories of childhood vasculitis including Henoch-Schonlein purpura, Kawasaki disease, polyarteritis nodosa (with additionally definitions for cutaneous and microscopic polyarteritis), Wegener granulomatosis and Takayasu arteritis. The process involved the Delphi technique to gather a wide spectrum of opinion from pediatric rheumatologists and nephrologists followed by the Consensus Conference attended by a group of pediatricians with extensive vasculitis experience where nominal group techniques were utilized to agree on a general classification and classification criteria for individual childhood vasculitides. The consensus that was reached will hopefully provide pediatricians with a valuable tool in the study of childhood vasculitides but will require appropriate validation using patient and control groups.

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Introduction to, and classification of, the systemic vasculitides

Cited by 18 publications

References 50 publications

Problems in classifying vasculitis in children

Problems in classifying vasculitis in children

Screening of serum samples from Wegener's granulomatosis patients using antibody microarrays

A new international classification of childhood vasculitis

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