Introduction to a Compendium on Sudden Cardiac Death

Tomaselli, Gordon F.

doi:10.1161/circresaha.115.306515

Cited by 15 publications

(9 citation statements)

References 25 publications

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“…; Goldberger et al . ; Tomaselli, ), one of the most important issues in public health today. In recent years, the identification of ion channel mutations that may trigger fatal arrhythmias in the absence of structural heart disease (SHD) has been an important new area of research (Napolitano et al .…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the occurrence of an event is unpredictable, sudden and often catastrophic. These characteristics make the prevention of sudden cardiac death (SCD), which according to recent data can be attributable to a malignant VA in up to 30-40% of cases (Cobb et al 2002;Goldberger et al 2014;Tomaselli, 2015), one of the most important issues in public health today. In recent years, the identification of ion channel mutations that may trigger fatal arrhythmias in the absence of structural heart disease (SHD) has been an important new area of research (Napolitano et al 2012).…”

Section: Introductionmentioning

confidence: 99%

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Therapy for ventricular arrhythmias in structural heart disease: a multifaceted challenge

Proietti

Joza

Essebag

2016

The Journal of Physiology

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The unpredictable nature and potentially catastrophic consequences of ventricular arrhythmias (VAs) have obligated physicians to search for therapies to prevent sudden cardiac death (SCD). At present, a low left ventricular ejection fraction (LVEF) has been used as a risk factor to predict SCD in patients with structural heart disease and has been consistently adopted as the predominant, and sometimes sole, indication for implantable cardioverter defibrillator (ICD) therapy. Although the ICD remains the mainstay life-saving therapy for SCD, it does not modify the underlying arrhythmic substrate and may be associated with adverse effects from perioperative and long-term complications. Preventative pharmacological therapy has been associated with limited benefits, but anti-arrhythmic medications have significant side effects profiles. Catheter ablation of VAs has greatly evolved over the last few decades. Substrate mapping in sinus rhythm has allowed haemodynamically unstable VAs to be successfully treated. Both LVEF as an indication for ICD therapy and electro-anatomical mapping for substrate modification identify static components of underlying myocardial arrhythmogenicity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapy for ventricular arrhythmias in structural heart disease: a multifaceted challenge

Proietti

Joza

Essebag

2016

The Journal of Physiology

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“…[10] Coronary heart disease is the most common pathology underlying SCA. [11] Despite advances in coronary heart disease treatment, SCA accounts for about 450,000 annual deaths in the United States (US),[12] nearly 100,000 of which are in persons with DM. [13] The pathophysiology of SCA is complex, requiring an underlying substrate and a transient event that induces electric instability and a ventricular arrhythmia (VA) followed by hemodynamic collapse.…”

Section: Sudden Cardiac Arrest An Arrhythmic Sequela In the Settingmentioning

confidence: 99%

Pro- and Antiarrhythmic Actions of Sulfonylureas: Mechanistic and Clinical Evidence

Leonard

Hennessy

Han

et al. 2017

Trends in Endocrinology & Metabolism

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Sulfonylureas are the most commonly-used second line drug class for treating type 2 diabetes mellitus. While the cardiovascular safety of sulfonylureas has been examined in a number of trials and non-randomized studies, little is known of their specific effects on sudden cardiac arrest and related serious arrhythmic outcomes. This knowledge gap is striking, as persons with diabetes mellitus are at increased risk of sudden cardiac arrest. This review explores sulfonylureas’ influence on the risk of serious arrhythmias, with specific foci on ischemic preconditioning, cardiac excitability, and serious hypoglycemia as putative mechanisms. Elucidating the relationship between individual sulfonylureas and serious arrhythmias is critical, especially as the diabetes epidemic intensifies and sudden cardiac arrest incidence increases in persons with diabetes.

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“…Sudden cardiac death (SCD) is considered a major cause of worldwide mortality, yet incidence estimates vary widely because of variable data sources and definitions. 1, 2 Studies based on death certificate review are known to overestimate incidence due to inaccuracies in stated causes of death, 3 and investigations relying on emergency medical system (EMS) records 4 and epidemiologic definitions 5-7 presume cardiac etiology or infer cardiac cause of death. Expert panels have advocated for the use of precise and uniform definitions of SCD and to integrate multiple sources of ascertainment, 8 but non-cardiac and non-arrhythmic conditions leading to sudden death cannot be excluded without a complete autopsy.…”

Section: Introductionmentioning

confidence: 99%

Prospective Countywide Surveillance and Autopsy Characterization of Sudden Cardiac Death

Tseng¹,

Olgin²,

Vittinghoff³

et al. 2018

Circulation

214

175

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Introduction to a Compendium on Sudden Cardiac Death

Cited by 15 publications

References 25 publications

Therapy for ventricular arrhythmias in structural heart disease: a multifaceted challenge

Therapy for ventricular arrhythmias in structural heart disease: a multifaceted challenge

Pro- and Antiarrhythmic Actions of Sulfonylureas: Mechanistic and Clinical Evidence

Prospective Countywide Surveillance and Autopsy Characterization of Sudden Cardiac Death

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