Abstract:Background: a-1,2-Mannosidase is an important enzyme essential for N-glycan processing and plays a significant role in the biosynthesis and organization of fungal cell wall. Lacking of α-1,2-mannosidase leads to cell wall defect in yeast and filamentous fungi. In Trichoderma reesei, a fungus known to be non-toxic to human, its N-glycan on secreted glycoprotein is Man8GlcNAc2, which is different from that in Aspergillus fumigatus. To evaluate the significance of the N-glycan processing in T. reesei, in this stu… Show more
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