Introduction of Sb (V)-metalloid ion supported on mesoporous Nano- γ-alumina as an effective catalytic system for the synthesis of highly substituted tetrahydropyridines under ultrasonic and thermal conditions

Abstract

Background In this research work, Nano-γ-Al2O3/Sb(V) was synthesized and characterized as a heterogeneous Lewis acid catalyst. Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscopy, Brunauer–Emmett–Teller plot, Energy Dispersive X-ray Spectroscopy and Thermo Gravimetric Analysis were used to characterization of Nano-γ-Al2O3/Sb(V). Tetrahydropyridine, is known as the nuclear structure in some natural products and drugs. Results Poly substituted tetrahydropyridine-3-carboxylates are synthesized via one pot multi component reaction of ethyl acetoacetate, aldehyde and aniline derivative. This present study introduces synthesis of tetrahydropyridine-3-carboxylate in the presence of Nano-γ-Al2O3/Sb(V) under ultrasonic and thermal conditions. Conclusion Compared to the previously reported methods, our attitude is suitable and offers several benefits such as milder reaction conditions, shorter reaction time, excellent yields and use of reusable catalyst.