Introduction of oxygenated side chain into imidazolium ionic liquids: Evaluation of the effects at different biological organization levels

Samorì, Chiara; Malferrari, Danilo; Valbonesi, Paola; Montecavalli, Adele; Moretti, Fabio; Galletti, Paola; Sartor, Giorgio; Tagliavini, Emilio; Fabbri, Elena; Pasteris, Andrea

doi:10.1016/j.ecoenv.2010.07.020

Cited by 115 publications

(83 citation statements)

References 81 publications

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“…Recent toxicological studies have focused on a new class of ILs with increased biodegradability through the incorporation of oxygen atoms [26]. It was previously shown that the introduction of one oxygen atom into the lateral chain of imidazolium-based ILs seemed to decrease the toxicity of the IL with respect to alkyl counter parts towards the crustacean Daphnia magna and the bacterium Vibrio fischeri [27,28]. This observation is in agreement with our observation -the low anti-microbial activity of [Cho][Ser] compared to the other ILs in the present study.…”

Section: Acute Toxicity Of Ilmentioning

confidence: 99%

Understanding the physical properties, toxicities and anti-microbial activities of choline-amino acid-based salts: Low-toxic variants of ionic liquids

Foulet

Ghanem

El‐Harbawi

et al. 2016

Journal of Molecular Liquids

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Section: Acute Toxicity Of Ilmentioning

confidence: 99%

Understanding the physical properties, toxicities and anti-microbial activities of choline-amino acid-based salts: Low-toxic variants of ionic liquids

Foulet

Ghanem

El‐Harbawi

et al. 2016

Journal of Molecular Liquids

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“…With reference to this problem, along with scientific reports on the synthesis, physical and chemical properties and the potential for practical utilization of ionic liquids, a large number of studies have come up, which are concerned with the examination of the potential toxicity of these substances. Studies described in available literature reveal varied influences of ionic liquids on microorganisms [1,2,[17][18][19][20][21][22], plankton [21,[23][24][25][26], invertebrates [27][28][29], vertebrates [27,30], algae [2,21,23,29,[31][32][33], fungi [19,34,35] or higher land plants [8,21,31,[36][37][38][39]. The quoted literature shows that a likely toxic influence of a ionic liquid is determined by a number of factors, of which the primary role is played the cation type and the length of the substituent in the cation (as a rule, the longer alkyl chain, the higher toxicity).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Phytotoxicity of Selected Phosphonium Ionic Liquid

Biczak

Bałczewski

Pawłowska

et al. 2014

Ecological Chemistry and Engineering S

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Ionic liquids have attracted considerable interest in various areas as new, non-volatile and nonflammable organic solvents, catalysts, reaction additives, ligands, drugs and other dedicated materials etc. Their general use, sometimes in bulky quantities, requires determination of their potential ecotoxicity on selected organisms. In the present work, influence of triphenylmethylphosphonium iodide (1) and triphenylhexadecylphosphonium iodide (2), introduced to soil, on germination and early stages of growth and development of superior plants was investigated using the plant growth test based on the OECD/OCDE 208/2006. In this test, the seeds of selected species, i.e. land superior plants -spring barley (Hordeum vulgare) and common radish (Raphanus sativus L. subvar. radicula Pers.) were planted in pots containing soil to which a test chemical compound had been added and in pots with control soil. To evaluate the phytotoxicity of ionic liquids 1 and 2 germination and weight (dry and fresh) of control plant seedlings were determined and compared with the germination and weight (dry and fresh) of the seedlings of plants grown in the soil watered with appropriate amounts of the test chemicals. The visual assessment of any types of damage to the test species, such as growth inhibition, chlorosis and necrosis, was also carried out and documented by digital photographs. Based on the obtained results, magnitudes of the LOEC -the lowest concentration causing observable effects in the form of reduction in growth and germination compared with the control and the NOEC -the highest concentration not causing observable, toxic effects -were also determined.

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“…It is suggested that cytotoxicity tests using dedifferentiated cancer cells provide a quick and convenient fi rst information about the toxic potential of chemical substances (6). The effects of ionic liquids on cell viability have already been reported in wellcharacterised tumour mammalian cell lines such as HeLa (7), CaCo-2 (8), MCF7 (9), and PC12 (10). Investigations of the effects of ionic liquids on the aquatic environment have mostly been based on the evaluation of the growth and survival of different aquatic organisms (11)(12).…”

mentioning

confidence: 99%

Cytotoxic Effects of Imidazolium Ionic Liquids on Fish and Human Cell Lines

Cvjetko

Radošević

Tomica

et al. 2012

Archives of Industrial Hygiene and Toxicology

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Ionic liquids bring a promise of a wide range of "green" applications that could replace conventional volatile solvents. However, before these applications become large-scale, their toxicity needs to be investigated in order to predict the impact on human health and environment. In this study we assessed the cytotoxicity of imidazolium ionic liquids (in the concentrations between 0.1 mmol L -1 and 10 mmol L -1 ) in the ovarian fi sh cell line CCO and the human tumour cell line HeLa using the MTT cell viability assay. Our results showed that the most cytotoxic ionic liquid was 1-n-butyl-3-methylimidazolium bis(trifl uoro methylsulphonyl)imide, [BMIM][Tf 2 N], followed by 1-n-butyl-3-methylimidazolium tetrafl uoroborate [BMIM] [BF 4 ], 1-n-butyl-3-methylimidazolium hexafluorophosphate [BMIM] [PF 6 ], and 1,3-dimethylimidazolium hexafl uorophosphate [MMIM] [PF 6 ]. Generally, the effects were concentrationdependent. They also depended on the type of anion and the n-alkyl chain length. The comparison between the fi sh CCO and human HeLa cell lines suggests that CCO cells provide a good biological system for initial toxicity testing of ionic liquids that could replace in vivo bioassays.

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Introduction of oxygenated side chain into imidazolium ionic liquids: Evaluation of the effects at different biological organization levels

Cited by 115 publications

References 81 publications

Understanding the physical properties, toxicities and anti-microbial activities of choline-amino acid-based salts: Low-toxic variants of ionic liquids

Understanding the physical properties, toxicities and anti-microbial activities of choline-amino acid-based salts: Low-toxic variants of ionic liquids

Comparison of Phytotoxicity of Selected Phosphonium Ionic Liquid

Cytotoxic Effects of Imidazolium Ionic Liquids on Fish and Human Cell Lines

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