2009
DOI: 10.1371/journal.pntd.0000390
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Introduction of Dengue Virus 4 (DENV-4) Genotype I into Brazil from Asia?

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Cited by 38 publications
(40 citation statements)
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References 12 publications
(17 reference statements)
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“…In contrast, the DENV4 from Manaus in 2008 belonged to genotype I, which is Asiatic and has never been described on the American continent. DENV4 isolates from Manaus group together with the Philippines/1956/H241 (AY947539) and China_Guangzhou_B5 (AF289029) strains (7) . This virus has been in Manaus for several years, producing cases of acute febrile illness but most likely not spreading to other parts of Brazil.…”
Section: Dengue Fevermentioning
confidence: 99%
“…In contrast, the DENV4 from Manaus in 2008 belonged to genotype I, which is Asiatic and has never been described on the American continent. DENV4 isolates from Manaus group together with the Philippines/1956/H241 (AY947539) and China_Guangzhou_B5 (AF289029) strains (7) . This virus has been in Manaus for several years, producing cases of acute febrile illness but most likely not spreading to other parts of Brazil.…”
Section: Dengue Fevermentioning
confidence: 99%
“…Infections by DENV1 have the most serious symptoms [4], [5], [6]. Recently, Dengue virus infections are caused by superinfections or by the genetically mutated viruses rather than monoinfections.…”
Section: Dengue Virusmentioning
confidence: 99%
“…However, a distinct DENV-4, belonging to genotype I, that was never reported in the Americas has infected patients from Manaus City, in the Amazon State, since 2005. This rather unexpected virus was likely introduced directly to Manaus by intense economic activity and movement of people from Asian companies, particularly from China (5) . Years later, the same DENV-4 of genotype I was reported in Northeast Brazil.…”
Section: How Are So Many Foreign Arboviruses Introduced In Brazil?mentioning
confidence: 99%