Introduction of blastocyst culture and transfer for all patients in an in vitro fertilization program

Marek, D.; Langley, M.; Gardner, David K.; Confer, Nils; Doody, K.M.; Doody, Kevin J.

doi:10.1016/s0015-0282(99)00409-4

Cited by 176 publications

(68 citation statements)

References 16 publications

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“…Also, some prospective studies have shown that a significantly higher implantation rate in SBET compared to that in eSCET in fresh cycles [12,20]. However, the biggest drawback of extended culture is related to a higher incidence of embryo transfer cancellation and fewer embryos cryopreserved due to failed blastocysts development [17,20]. According to a recent prospective study comparing DBET with SBET in women under 36 years of old without top-quality embryos on day 2, the ET cancellation rate of SBET was significantly higher than that of DCET (12 % vs. 0 %, p<0.001) [11], but the pregnancy rate and delivery rate per oocyte retrieval of SBET were similar to those of DCET.…”

Section: Discussionmentioning

confidence: 99%

Comparison of clinical outcomes between single and double vitrified-warmed blastocyst embryo transfer according to the day of vitrification

Kang

Lee

Yoon

et al. 2013

J Assist Reprod Genet

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Purpose To compare the efficacy of single vitrified-warmed blastocyst embryo transfer (SVBT) versus double vitrifiedwarmed blastocyst embryo transfer (DVBT) according to the day of vitrification. Methods This retrospective study included a total of 1,051 cycles in women less than 37 years of age with their autologous SVBT cryopreserved on day 5 (5d-SVBT, n=737) or day 6 (6d-SVBT, n=154) and DVBT on day 5 (5d-DVBT, n=129) or day 6 (6d-DVBT, n=31) from January 2009 to December 2011. Results The clinical pregnancy rate (41.8 % vs. 48.1 %, p=0.184) and ongoing pregnancy rate (36.6 % vs. 45.0 %, p=0.072) were not significantly different between the 5d-SVBT group and the 5d-DVBT group. However, the clinical pregnancy (29.9 % vs. 58.1 %, p=0.003) and ongoing pregnancy rates (23.4 % vs. 51.6 %, p=0.001) were significantly lower in the 6d-SVBT group compared with those in the 6d-DVBT group. The implantation rate (42.2 % vs. 34.5 %, p=0.03) of the 5d-SVBT group was significantly higher than that of the 5d-DVBT group, while the implantation rate (29.9 % vs. 37.1 %, p=0.303) of the 6d-SVBT group was not statistically different compared with that in the 6d-DVBT group. The multiple pregnancy rates (1.0 % in the 5d-SVBT group vs. 38.7 % in the 5d-DVBT group, p<0.001 and 0 % in the 6d-SVBT group vs. 22.2 % in the 6d-DVBT group, p=0.001) were statistically significantly lower in the SVBT group compared with those in the DVBT group regardless of the day of vitrification. Conclusions This study showed that the 5d-SVBT resulted in comparable clinical outcomes compared to the 5d-DVBT while the 6d-SVBT yielded significantly lower clinical outcomes compared to the 6d-DVBT.

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Section: Discussionmentioning

confidence: 99%

Comparison of clinical outcomes between single and double vitrified-warmed blastocyst embryo transfer according to the day of vitrification

Kang

Lee

Yoon

et al. 2013

J Assist Reprod Genet

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“…Improved pregnancy rates by virtue of making the IVF-ET environment closer to the physiological state were anticipated. Nevertheless, in its early stages BT did not yield significantly higher implantation and pregnancy rates, compared with D2/3 ET [4]. The exponential growth in the clinical application of BT in recent years, with improved implantation and pregnancy rates, is considered to be due to the recent advances in the culture system based on clarification of important nutrients required for early human embryogenesis [5].…”

Section: Blastocyst Transfer -Its Efficacy and Problemsmentioning

confidence: 99%

Blastocyst Transfer - Its Efficacy and Problems

2003

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“…Therefore, the Assisted Reproductive Technology clinics have to decide which day to perform the embryo transfer after an in vitro fertilization (IVF). Blastocyst transfer has beenassociated with a significant increase in the implantation rate, resulting in a reduction of the number of embryos transferred to attain acceptable pregnancy rates, 1,2 Certainly, in younger patients, and those with good ovarian reserve, blastocyst transfer appearsto be a more effective treatment and lookslike the most promising stage, to replace inthe uterus when one considers the move tosingle embryo transfer. Conventionally, human embryos conceived through IVF are transferred after fertilizationon the second or third day of developmentwhile at the 4-to 8-cell stage.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Pregnancy Outcome in Day 2 Embryo Transfer versus Day 5 Transfer

Lele¹,

Dnb²

2017

jmscr

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Introduction of blastocyst culture and transfer for all patients in an in vitro fertilization program

Cited by 176 publications

References 16 publications

Comparison of clinical outcomes between single and double vitrified-warmed blastocyst embryo transfer according to the day of vitrification

Comparison of clinical outcomes between single and double vitrified-warmed blastocyst embryo transfer according to the day of vitrification

Blastocyst Transfer - Its Efficacy and Problems

Comparative Study of Pregnancy Outcome in Day 2 Embryo Transfer versus Day 5 Transfer

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