Introduction

Amiard‐Triquet, Claude

doi:10.1016/b978-0-12-800949-9.00001-2

Cited by 5 publications

(3 citation statements)

References 86 publications

(72 reference statements)

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“…The environmental pollution has become a global crucial issue. Several pollutants and contaminants enter the environment either because of anthropogenic activities like industry, agriculture, transport, everyday life, etc., or through naturally occurring event [ 59 , 60 ]. Pollutants and contaminants can be air-, soil-, or waterborne, and may move from one medium to other (for example, soil to water).…”

Section: Applicationsmentioning

confidence: 99%

Ten Years of Lateral Flow Immunoassay Technique Applications: Trends, Challenges and Future Perspectives

Nardo

Chiarello

Cavalera

et al. 2021

Sensors

234

162

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The Lateral Flow Immunoassay (LFIA) is by far one of the most successful analytical platforms to perform the on-site detection of target substances. LFIA can be considered as a sort of lab-in-a-hand and, together with other point-of-need tests, has represented a paradigm shift from sample-to-lab to lab-to-sample aiming to improve decision making and turnaround time. The features of LFIAs made them a very attractive tool in clinical diagnostic where they can improve patient care by enabling more prompt diagnosis and treatment decisions. The rapidity, simplicity, relative cost-effectiveness, and the possibility to be used by nonskilled personnel contributed to the wide acceptance of LFIAs. As a consequence, from the detection of molecules, organisms, and (bio)markers for clinical purposes, the LFIA application has been rapidly extended to other fields, including food and feed safety, veterinary medicine, environmental control, and many others. This review aims to provide readers with a 10-years overview of applications, outlining the trends for the main application fields and the relative compounded annual growth rates. Moreover, future perspectives and challenges are discussed.

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Section: Applicationsmentioning

confidence: 99%

Ten Years of Lateral Flow Immunoassay Technique Applications: Trends, Challenges and Future Perspectives

Nardo

Chiarello

Cavalera

et al. 2021

Sensors

234

162

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“…Aquatic ecotoxicity is of primary regulatory concern as it is one of the major determinants in the well-being of terrestrial and aquatic species alike [93]. We identified 2 cadmium-AOPs namely ‘Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2’ (AOP:21) and ‘Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF’ (AOP:150), that are part of LCC (C1), and have ‘High’ evidence of applicability in aquatic species (Supplementary Table S7).…”

Section: Resultsmentioning

confidence: 99%

An integrative data-centric approach to derivation and characterization of an adverse outcome pathway network for cadmium-induced toxicity

Sahoo,

Chivukula,

Ramesh

et al. 2023

Preprint

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Cadmium is a prominent toxic heavy metal that contaminates both terrestrial and aquatic environments. Owing to its high biological half-life and low excretion rates, cadmium causes a variety of adverse biological outcomes. Adverse outcome pathway (AOP) networks were envisioned to systematically capture toxicological information to enable risk assessment and chemical regulation. Here, we leveraged AOP-Wiki and integrated heterogeneous data from four other exposome-relevant resources to build the first AOP network relevant for inorganic cadmium-induced toxicity. From AOP-Wiki, we filtered 309 high confidence AOPs, identified 312 key events (KEs) associated with inorganic cadmium, and thereafter, curated 30 cadmium relevant AOPs (cadmium-AOPs), using a data-centric approach. By constructing the undirected AOP network, we identified a large connected component of 18 cadmium-AOPs. Further, we analyzed the directed network of 59 KEs and 82 key event relationships (KERs) in the largest component using graph-theoretic approaches. Subsequently, we mined published literature using artificial intelligence-based tools to provide auxiliary evidence of cadmium association for all KEs in the largest component. Finally, we performed case studies to verify the rationality of cadmium-induced toxicity in humans and aquatic species. Overall, cadmium-AOP network constructed in this study will aid ongoing research in systems toxicology and chemical exposome.

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“…It is estimated that around 100,000 molecules are introduced into aquatic environments from different sources, where mixtures of several classes of contaminants are present concurrently, and can interact additively, synergistically or antagonistically (Amiard-Triquet, 2015). Chemical analyses of these environments provide only information about the nature of a limited number of target substances and their concentrations in the environment, disregarding their bioavailability and potential harmful effects on biota.…”

Section: Introductionmentioning

confidence: 99%

Zebrafish as a biological model for assessing water quality along tropical hydrographic river basins in Northeast Brazil

Alves,

Mariz,

de Melo Alves

et al. 2023

Ecotoxicology

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Tropical rivers are the main destinations for tailings from urban, industrial and agricultural activities. The present study aimed to investigate if early stages of zebra sh (Danio rerio) development is a viable biological model to assess the toxicity of surface waters of tropical rivers, and whether that toxicity could be correlated to standard water quality indexes. Embryos were exposed to samples from 55 sites from 10 hydrographic basins of rivers in Pernambuco State, northeastern Brazil. Lethality rates, sublethal toxicity based on the general morphology score (GMS) and frequencies of abnormalities were analyzed. Signi cant mortality was observed in samples of 7 basins. The GMS indicated signi cant delay in embryo-larval development in 50% of the samples. Highest toxicity was detected in basins within Recife metropolitan area, where 61% of the samples caused sublethal toxicity. Most frequent developmental abnormalities included non-in ation of the swim bladder, delayed hatching and blood stasis. Highest frequencies of blood stasis were detected in samples with highest NH 3 concentrations, corroborated by a positive correlation suggesting the existence of a causal relationship. A signi cant correlation was detected between water quality indexes and GMS with a greater toxic effect being observed in samples collected in areas of greater urban density and greater contamination by domestic sewage. This study demonstrates that the early stages of the zebra sh is a viable ecotoxicological model to assess the toxicity of surface waters and can contribute to a better understanding between the chemical composition and the adverse effects suffered by sh early life stages in tropical rivers.

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Introduction

Cited by 5 publications

References 86 publications

Ten Years of Lateral Flow Immunoassay Technique Applications: Trends, Challenges and Future Perspectives

Ten Years of Lateral Flow Immunoassay Technique Applications: Trends, Challenges and Future Perspectives

An integrative data-centric approach to derivation and characterization of an adverse outcome pathway network for cadmium-induced toxicity

Zebrafish as a biological model for assessing water quality along tropical hydrographic river basins in Northeast Brazil

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