Introduction: Feature Issue on Phantoms for the Performance Evaluation and Validation of Optical Medical Imaging Devices

Optical phantoms are widely used for evaluating the performance of biomedical optical modalities, and hence, absorbing and scattering materials are required for the construction of optical phantoms. Towards that aim, new readily available and inexpensive black Ink (Parker) as a simulating absorber as well as Intralipid 20% as a simulating scatterer are thoroughly investigated. Broadband Transmittance and Diffuse reflectance spectroscopic measurements were performed in the visible range 400 -700 nm. Optical properties of the phantom materials are determined. Analytical expressions for absorption and scattering coefficient related to the concentrations and wavelength of the Parker ink and Intralipid are also presented and discussed. The results show nonlinear trend in the absorption coefficient of Parker ink over the examined visible spectral range. Furthermore, Intralipid scattering coefficient variation across the mentioned spectral range shows a tissue-like scattering trend. The findings demonstrate the capability of the broadband transmission and diffuse reflectance for characterizing tissue-like phantom materials in the examined spectral range.

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“…Since biological tissue is a turbid medium, optical phantom must have scattering and absorbing components [3].…”

Section: Introductionmentioning

confidence: 99%

Broadband spectroscopy for characterization of tissue-like phantom optical properties

Shahin

Bachir

2017

Polish Journal of Medical Physics and Engineering

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“…Such optical measurement systems for biomedical applications rely on tissue-equivalent phantoms for testing system design and comparing di®erent measurement methods. [2][3][4][5][6][7][8][9] Use of real human tissues is impractical since the optical properties of such samples change in various atmospheric conditions (i.e., humidity, temperature) and rapidly degrade over time, thus they are unusable as standards with known and stable properties. Therefore, optical properties of phantoms (scattering coe±cient s , absorption coe±cient a , scattering anisotropy factor g, refractive index n, and thickness L) should be properly tuned to correspond to that of tissues they mimic.…”

Section: Introductionmentioning

confidence: 99%

Multi-layered tissue head phantoms for noninvasive optical diagnostics

Wróbel

Попов

Bykov

et al. 2015

J. Innov. Opt. Health Sci.

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Extensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with optical properties similar to those of living human tissues. Development and improvement of in vivo optical measurement systems requires the use of stable tissue phantoms with known characteristics, which are mainly used for calibration of such systems and testing their performance over time. Optical and mechanical properties of phantoms depend on their purpose. Nevertheless, they must accurately simulate speci¯c tissues they are supposed to mimic. Many tissues and organs including head possess a multi-layered structure, with speci¯c optical properties of each layer. However, such a structure is not always addressed in the presentday phantoms. In this paper, we focus on the development of a plain-parallel multi-layered phantom with optical properties (reduced scattering coe±cient 0 s and absorption coe±cient a ) corresponding to the human head layers, such as skin, skull, and gray and white matter of the brain tissue. The phantom is intended for use in noninvasive di®use near-infrared spectroscopy (NIRS) of human brain. Optical parameters of the fabricated phantoms are reconstructed using spectrophotometry and inverse adding-doubling calculation method. The results show that polyvinyl chloride-plastisol (PVCP) and zinc oxide (ZnO) nanoparticles are suitable materials for fabrication of tissue mimicking phantoms with controlled scattering properties. Good matching

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“…15,16 A key requirement for such applications to grow and gain a more widespread clinical or industrial acceptance is to achieve a high grade of reliability, reproducibility, accuracy in quantification, and comparability of clinical results. 17 There is a compelling need to nurture the culture of quality assessment and quantitative grading of instruments in diffuse optics to support the parallel development of new instruments/techniques and applications on a stringent basis. [18][19][20] The main path to reach these goals is the adoption of protocols for performance assessment to measure and characterize the system behavior.…”

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confidence: 99%

“…Different solutions for the construction of inhomogeneous phantoms were proposed, as shown in the review papers 25,26 and in a recent special issue of Biomedical Optics Express, 17 adopting liquid-liquid, 27 liquid-solid, [28][29][30] and solid-solid structures, [31][32][33][34] each of them with different advantages and criticalities. To comply with the requirements (1), (2), and (4) we opted for a solid-solid approach, obviously more practical than liquid-liquid or mixed approaches.…”

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confidence: 99%

Mechanically switchable solid inhomogeneous phantom for performance tests in diffuse imaging and spectroscopy

et al. 2015

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Abstract. A mechanically switchable solid inhomogeneous phantom simulating localized absorption changes was developed and characterized. The homogeneous host phantom was made of epoxy resin with black toner and titanium dioxide particles added as absorbing and scattering components, respectively. A cylindrical rod, movable along a hole in the block and made of the same material, has a black polyvinyl chloride cylinder embedded in its center. By varying the volume and position of the black inclusion, absorption perturbations can be generated over a large range of magnitudes. The phantom has been characterized by various timedomain diffuse optics instruments in terms of absorption and scattering spectra, transmittance images, and reflectance contrast. Addressing a major application of the phantom for performance characterization for functional near-infrared spectroscopy of the brain, the contrast was measured in reflectance mode while black cylinders of volumes from ≈20 mm 3 to ≈270 mm 3 were moved in lateral and depth directions, respectively. The new type of solid inhomogeneous phantom is expected to become a useful tool for routine quality check of clinical instruments or implementation of industrial standards provided an experimental characterization of the phantom is performed in advance.

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Introduction: Feature Issue on Phantoms for the Performance Evaluation and Validation of Optical Medical Imaging Devices

Cited by 40 publications

References 44 publications

Broadband spectroscopy for characterization of tissue-like phantom optical properties

Broadband spectroscopy for characterization of tissue-like phantom optical properties

Multi-layered tissue head phantoms for noninvasive optical diagnostics

Mechanically switchable solid inhomogeneous phantom for performance tests in diffuse imaging and spectroscopy

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