Introduction and guidelines on the use of the Handbook

Britton, George; Liaaen-Jensen, h.c. Synnøve; Pfander, Hanspeter

doi:10.1007/978-3-0348-7836-4_1

Cited by 55 publications

(75 citation statements)

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“…Carotenoids are colored (red, orange, and yellow) pigments widely distributed in nature with over 700 structurally different compounds [ 279 ]. These lipophilic molecules are synthesized in photosynthetic organelles as well as in fruits, flowers, seeds, and storage roots.…”

Section: Dietary Natural Pigments With Biological Activitymentioning

confidence: 99%

Natural Dietary Pigments: Potential Mediators against Hepatic Damage Induced by Over-The-Counter Non-Steroidal Anti-Inflammatory and Analgesic Drugs

et al. 2018

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Over-the-counter (OTC) analgesics are among the most widely prescribed and purchased drugs around the world. Most analgesics, including non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen, are metabolized in the liver. The hepatocytes are responsible for drug metabolism and detoxification. Cytochrome P450 enzymes are phase I enzymes expressed mainly in hepatocytes and they account for ≈75% of the metabolism of clinically used drugs and other xenobiotics. These metabolic reactions eliminate potentially toxic compounds but, paradoxically, also result in the generation of toxic or carcinogenic metabolites. Cumulative or overdoses of OTC analgesic drugs can induce acute liver failure (ALF) either directly or indirectly after their biotransformation. ALF is the result of massive death of hepatocytes induced by oxidative stress. There is an increased interest in the use of natural dietary products as nutritional supplements and/or medications to prevent or cure many diseases. The therapeutic activity of natural products may be associated with their antioxidant capacity, although additional mechanisms may also play a role (e.g., anti-inflammatory actions). Dietary antioxidants such as flavonoids, betalains and carotenoids play a preventive role against OTC analgesics-induced ALF. In this review, we will summarize the pathobiology of OTC analgesic-induced ALF and the use of natural pigments in its prevention and therapy.

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Section: Dietary Natural Pigments With Biological Activitymentioning

confidence: 99%

Natural Dietary Pigments: Potential Mediators against Hepatic Damage Induced by Over-The-Counter Non-Steroidal Anti-Inflammatory and Analgesic Drugs

et al. 2018

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“…They are the most widespread group of pigments -the number of naturally occurring carotenoids continues to rise and has reached about 750 (Britton, Liaaen-Jensen, & Pfander, 2004). More than 25 different pigments have been identified in the fruits of paprika: green chlorophylls, yellow-orange lutein, zeaxanthin, violaxanthin, antheraxanthin, b-cryptoxanthin, b-carotene, etc.…”

Section: Introductionmentioning

confidence: 99%

Pigment content and fatty acid composition of paprika oleoresins obtained by conventional and supercritical carbon dioxide extraction

Tepić

Zeković

Kravić

et al. 2009

CyTA - Journal of Food

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“…The essentially structureless spectral form with a 73% yield (62% if we consider 15% of red states are present in dark adapted sample) is very similar to the absorption of echinenone in organic solvents. On the contrary, its difference to the orange OCP O state is more reminiscent of the absorption of the cis isomer of lutein …”

Section: Discussionmentioning

confidence: 99%

Stages of OCP-FRP Interactions in the Regulation of Photoprotection in Cyanobacteria, Part 1: Time-Resolved Spectroscopy

et al. 2023

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Most cyanobacteria utilize a water-soluble Orange Carotenoid Protein (OCP) to protect their light-harvesting complexes from photodamage. The Fluorescence Recovery Protein (FRP) is used to restore photosynthetic activity by inactivating OCP via dynamic OCP–FRP interactions, a multistage process that remains underexplored. In this work, applying time-resolved spectroscopy, we demonstrate that the interaction of FRP with the photoactivated OCP begins early in the photocycle. Interacting with the compact OCP state, FRP completely prevents the possibility of OCP domain separation and formation of the signaling state capable of interacting with the antenna. The structural element that prevents FRP binding and formation of the complex is the short α-helix at the beginning of the N-terminal domain of OCP, which masks the primary site in the C-terminal domain of OCP. We determined the rate of opening of this site and show that it remains exposed long after the relaxation of the red OCP states. Observations of the OCP transitions on the ms time scale revealed that the relaxation of the orange photocycle intermediates is accompanied by an increase in the interaction of the carotenoid keto group with the hydrogen bond donor tyrosine-201. Our data refine the current model of photoinduced OCP transitions and the interaction of its intermediates with FRP.

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Introduction and guidelines on the use of the Handbook

Cited by 55 publications

References 0 publications

Natural Dietary Pigments: Potential Mediators against Hepatic Damage Induced by Over-The-Counter Non-Steroidal Anti-Inflammatory and Analgesic Drugs

Natural Dietary Pigments: Potential Mediators against Hepatic Damage Induced by Over-The-Counter Non-Steroidal Anti-Inflammatory and Analgesic Drugs

Pigment content and fatty acid composition of paprika oleoresins obtained by conventional and supercritical carbon dioxide extraction

Stages of OCP-FRP Interactions in the Regulation of Photoprotection in Cyanobacteria, Part 1: Time-Resolved Spectroscopy

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