Introduction: Amine oxidases and polyamines in biological systems

Agostinelli, Enzo

doi:10.1007/s00726-004-0113-5

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…The function of polyamine in symbiotic anthozoans is yet to be demonstrated, although a link with chromatin and RNA stabilization is possible (Igarashi & Kashiwagi 2010), as suggested by the numerous RNA‐ and DNA‐processing enzymes differentially expressed upon stress. Nevertheless, abundant literature in cancer research has associated deregulation of polyamine homeostasis in tumour tissues with oxidation‐induced cellular death (Agostinelli 2004; Casero & Pegg 2009). The enhanced expression of polyamine oxidase in A. viridis is an additional and unexpected source of ROS production.…”

Section: Discussionmentioning

confidence: 99%

The transcriptomic response to thermal stress is immediate, transient and potentiated by ultraviolet radiation in the sea anemone Anemonia viridis

Moya

Ganot²,

Furla

et al. 2012

Molecular Ecology

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Among the environmental threats to coral reef health, temperature and ultraviolet increases have been proposed as major agents, although the relative contribution of each in the cnidarian/zooxanthellae symbiosis breakdown has been poorly addressed. We have investigated the transcriptomic response to thermal stress, with and without ultraviolet radiation (UVR), in the symbiotic sea anemone Anemonia viridis. Using the Oligo2K A. viridis microarray, dedicated to genes potentially involved in the symbiosis interaction, we monitored the gene expression profiles after 1, 2 and 5 days of stresses that further lead to massive losses of zooxanthellae. Each stress showed a specific gene expression profile with very little overlap. We showed that the major response to thermal stress is immediate (24 h) but returns to the baseline gene expression profile after 2 days. UVR alone has little effect but potentiates thermal stress, as a second response at 5 days was observed when the two stresses were coupled. Several pathways were highlighted, such as mesoglea loosening, cell death and calcium homeostasis and described in more details. Finally, we showed that the dermatopontin gene family, potentially involved in collagen fibrillogenesis, issued from actinarian-specific duplication events, with one member preferentially expressed in the gastroderm and specifically responding to stress. Anemonia viridis EST sequences have been deposited into GenBank dbEST ([GenBank:FK719875–FK759813].

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Section: Discussionmentioning

confidence: 99%

The transcriptomic response to thermal stress is immediate, transient and potentiated by ultraviolet radiation in the sea anemone Anemonia viridis

Moya

Ganot²,

Furla

et al. 2012

Molecular Ecology

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“…The reaction of the etherate salts, 1 and 2, with one or two equivalents of 1,4-phenylenedimethanamine (ABM) at room temperature results in immediate formation of the dinuclear complexes [{(h 5 -C 5 R 5 )(CO) 2 Fe} 2 (m-PDA)] 2þ (R ¼ H (15), R ¼ CH 3 (16)) as the only isolable amine complexes. The dimers [(h 5 -C 5 R 5 ) Fe(CO) 2 ] 2 (R ¼ H, CH 3 ) were the only by-products isolated from the mother liquors.…”

Section: Reactions Of 1 and 2 With 14-phenylenedimethanamine (Pda)mentioning

confidence: 99%

Regioselective reactions of electrophilic iron dicarbonyl cations, [(η5-C5R5)(CO)2Fe]+ (R = H, CH3) with heterofunctional amine ligands

M’thiruaine

Friedrich

Changamu

et al. 2012

Journal of Organometallic Chemistry

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Arginase: a modulator of myocardial function

Post¹

2006

American Journal of Physiology-Heart and Circulatory Physiology

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WHEN NITRIC OXIDE (NO) donors were first administered to isolated, normal cardiomyocytes, a negative, cGMP-dependent inotropic effect was observed, whereas inhibitors of NO synthases (NOS) had no effect. Further studies then demonstrated a biphasic contractile response to exogenous NO and cGMP, explained by dose-dependent inhibition or activation of phosphodiesterases modulating cAMP. Also, exogenous NO can, via cGMP, activation of protein kinase G, and phosphorylation of troponin I, decrease myofilamental calcium responsiveness and exert cGMP-independent positive inotropic effects by nitrosylation. These in part contradictory findings are not surprising given the multiple mechanisms (via cGMP, nitrosylation, antioxidation), sites of production (cardiomyocytes, endothelial cells, nerve endings), and targets (mitochondrial respiration, glucose transport, cAMP turnover, L-type calcium channels, sarco(endo)plasmic reticulum Ca 2ϩ -ATPase, ryanodine receptor, myofilaments) of myocardial NO signaling known to date (11).Large animal studies demonstrated that there is a net positive inotropic effect of constitutive myocardial NO synthesis during normoperfusion and ischemia (6) and that basal NO release supports myocardial efficiency, i.e., the amount of myocardial work produced at a given level of oxygen consumption, during normoperfusion, ischemia (6), exercise (2), and pacing-induced heart failure (15). This was ascribed to a counterbalance of xanthine oxidase-derived oxygen radical production by NO (15). Importantly, heart failure represents a NO-deficient state by decreased myocardial production (14) and/or increased oxidative inactivation (1) of NO, whereas in the exercised heart, as the conceptual opposite of the failing myocardium, NO production and antioxidative capacity are increased (4,19). In line with that, upregulation of NO synthesis by statins attenuated heart failure after myocardial infarction in rats (13) or during tachycardic pacing in dogs (20).Knockout models of the constitutive NOS isoforms in mice showed that both endothelial NOS (eNOS) (17) and neuronal NOS (nNOS) (3, 16) support cardiac function after myocardial infarction and that the presence of eNOS is a prerequisite for the salutary effect of statins (9) and angiotensin-converting enzyme antagonism (10). In detail (11), eNOS is subcellularly localized to caveolae in the sarcolemma controlling ß-adrenergic signaling transduction at the level of cAMP and L-type calcium channels. nNOS colocalizes with the cardiac sarcoplasmic reticulum, limiting calcium cycling in the basal state but facilitating it during adrenergic and frequency (8) stimulation, although the precise mechanisms are still under debate. Taken together, constitutive myocardial NO synthesis is protective, sensitive to oxidative stress, and modulates myocardial function at multiple sites.It has been known for some time that in the vasculature, vasodilation by NO does not only depend on the presence of eNOS and is limited by oxidative inactivation of NO but also can be increased by...

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Introduction: Amine oxidases and polyamines in biological systems

Abstract: [No abstract available

Cited by 4 publications

References 4 publications

The transcriptomic response to thermal stress is immediate, transient and potentiated by ultraviolet radiation in the sea anemone Anemonia viridis

The transcriptomic response to thermal stress is immediate, transient and potentiated by ultraviolet radiation in the sea anemone Anemonia viridis

Regioselective reactions of electrophilic iron dicarbonyl cations, [(η5-C5R5)(CO)2Fe]+ (R = H, CH3) with heterofunctional amine ligands

Arginase: a modulator of myocardial function

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