Introduction

Liscombe, Rhodri Windsor

doi:10.2307/j.ctv6cfrdh.4

Cited by 2 publications

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“…3A, Fig. S3) [1,25]. In addition to the elucidation of the apo structure, cocrystallisation with SAM and different catechol substrates was carried out.…”

Section: Resultsmentioning

confidence: 99%

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Functional and structural characterisation of a bacterial O‐methyltransferase and factors determining regioselectivity

et al. 2017

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Mg -dependent catechol-O-methyltransferases occur in animals as well as in bacteria, fungi and plants, often with a pronounced selectivity towards one of the substrate's hydroxyl groups. Here, we show that the bacterial MxSafC exhibits excellent regioselectivity for para as well as for meta methylation, depending on the substrate's characteristics. The crystal structure of MxSafC was solved in apo and in holo form. The structure complexed with a full set of substrates clearly illustrates the plasticity of the active site region. The awareness that a wide range of factors influences the regioselectivity will aid the further development of catechol-O-methyltransferases as well as other methyltransferases as selective and efficient biocatalysts for chemical synthesis.

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“…3A, Fig. S3) [1,25]. In addition to the elucidation of the apo structure, cocrystallisation with SAM and different catechol substrates was carried out.…”

Section: Resultsmentioning

confidence: 99%

“…The irreversible methyl transfer onto one of the catechol hydroxyl groups follows an S N 2-type mechanism and often occurs with high regioselectivity (Fig. 1) [1]. The molecular basis for the regioselectivity in combination with a well-balanced substrate promiscuity is of particular interest regarding catechol OMT-catalysed reactions [7,[10][11][12].…”

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confidence: 99%

Functional and structural characterisation of a bacterial O‐methyltransferase and factors determining regioselectivity

et al. 2017

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“…55 It is not entirely clear when the work began but Liscombe's suggestion of 1809 seems most likely. 56 Drummond's neighbour Sir Francis Baring had commissioned George Dance to enlarge his house at East Stratton with the addition of a large portico, and this 'aroused the ire and contempt of Mr Henry Drummond [who] determined to show the country a real portico', at the cost of about £30,000. 57 Wilkins had recently produced his drawings of The Antiquities of Magna Graecia (1807) and won the competition to build Downing College, Cambridge, with a design in the Greek style.…”

Section: IImentioning

confidence: 99%

“…(1805-08). 58 The result was imposing though poorly articulated and impractical. At The Grange he was given the chance to integrate all his elevations into an academically accurate temple.…”

Section: IImentioning

confidence: 99%

The Grange, Northington

Geddes¹

1983

Architectural History

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In July 1972 the Hon. John Baring, owner of The Grange, Northington, Hampshire, held an auction to strip the house of all its saleable fittings: the staircase, doors, fireplaces and marble cladding were all removed. He then proposed to demolish the building, one of the earliest Greek Revival country houses in Europe, but the public outcry was so considerable that in 1975 it was taken into guardianship by the Department of the Environment. The house remained roofless and derelict until 1979–80 when the Department commissioned an independent architect, Donald Hankey, to restore the roof and exterior of the main east block and conservatory. The restoration presented a unique opportunity to examine the building in detail, revealing a great deal about the original seventeenth-century mansion, and how it had been converted to a Greek temple. The following account concentrates on the structural changes which took place in the main east block and in the conservatory. Some new information has also come to light about the gardens. The nineteenth-century extensions to the west of the house are omitted because they were demolished between 1972 and 1979, before restoration began.

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Introduction

Cited by 2 publications

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Functional and structural characterisation of a bacterial O‐methyltransferase and factors determining regioselectivity

Functional and structural characterisation of a bacterial O‐methyltransferase and factors determining regioselectivity

The Grange, Northington

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