Introduction

Agarwal, Ashok; Durairajanayagam, Damayanthi; Virk, Gurpriya; Plessis, Stefan S. du

doi:10.1007/978-3-319-10259-7_1

Cited by 4 publications

(4 citation statements)

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“…The activities of antioxidative enzymes in this study displayed similar trends or findings to those observed in former studies, suggesting that iron status may mediate testicular antioxidants and affect redox hemostasis. It has been reported that oxidative stress causes greater harmful effects in spermatozoa than in other cells [ 12 , 44 ], whereas both human and animal studies have demonstrated that SOD is present at relatively higher levels than other antioxidative enzymes, protecting spermatozoa via reduction of ROS [ 11 , 45 , 46 ]. The components of SOD contain metal ions [ 47 ], and our results showed that the iron-deficient rats had lower Mn-SOD and higher extracellular Cu/Zn-SOD protein expressions.…”

Section: Discussionmentioning

confidence: 99%

Effects of Iron Supplementation on Testicular Function and Spermatogenesis of Iron-Deficient Rats

et al. 2022

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Iron deficiency is the most common micronutrient deficiency in the world. Previous studies have shown that iron deficiency increases oxidative stress and decreases antioxidant enzymes, and studies of male infertility indicated that oxidative stress may affect male reproductive functions. The aim of this study was to investigate the effects of iron supplementation on spermatogenesis and testicular functions in iron-deficient rats. Three-week-old male Sprague Dawley (SD) rats were randomly divided into two groups: an iron-adequate control (AI group, 35 ppm FeSO4) and an iron-deficient group (ID group, <5 ppm FeSO4). After three weeks, the iron-deficient group was divided into an original iron-deficient group and five iron-supplemented groups, the latter fed diets containing different doses of FeSO4 (6, 12, 18, 24, and 35 ppm). After five weeks, blood and testis tissue were analyzed. We presented as median (interquartile range, IQR) for continuous measurements and compared their differences using the Kruskal–Wallis test followed by the Mann–Whitney U test among groups. The results showed that as compared with the AI group, the ID group had significantly lower serum testosterone and poorer spermatogenesis (The medians (QR) were 187.4 (185.6–190.8) of AI group vs. 87.5 (85.7–90.4) of ID group in serum testosterone, p < 0.05; 9.3 (8.8–10.6) of AI group vs. 4.9 (3.4–5.4) of ID group in mean testicular biopsy score (MTBS], p < 0.05); iron supplementation reversed the impairment of testis tissue. In the testosterone biosynthesis pathway, iron supplementation improved the lowered protein expressions of hydroxysteroid dehydrogenases caused by iron deficiency. Additionally, decreased activities of glutathione peroxidase and catalase, and increased cleaved-caspase 8 and caspase 3 expression, were found in the iron-deficient rats. The iron-supplemented rats that received > 12 ppm FeSO4 exhibited improvements in antioxidant levels. In conclusion, iron supplementation can abrogate testis dysfunction due to iron deficiency through regulation of the testicular antioxidant capacity.

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Section: Discussionmentioning

confidence: 99%

Effects of Iron Supplementation on Testicular Function and Spermatogenesis of Iron-Deficient Rats

et al. 2022

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“…Due to inadequate cell repair systems, spermatozoa have very little cytoplasmic content and consequently, the insufficient antioxidant content is exposed to OS (Dutta et al., 2019 ). Spermatozoa contain high levels of polyunsaturated fatty acids (PUFAs) in their plasma membranes and are susceptible to membrane lipid peroxidation (LPO), which reduces membrane fluidity (Agarwal et al., 2017 ). As a result, the membrane structure of sperm is damaged, leading to reduced motility and fertilization (Cho et al., 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Lycopene improves testicular damage and sperm quality in experimentally induced varicocele: Relationship with apoptosis, hypoxia, and hyperthermia

Babaei

Asadpour

Mansouri

et al. 2022

Food Science & Nutrition

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Varicocele is defined as high pressure, stasis in the spermatic veins, and venous enlargement of the scrotal pampiniform plexus (Yetkin & Ozturk, 2018). The prevalence of varicocele disease is about 35% and 80% with primary and secondary infertility, respectively (Alsaikhan et al., 2016). The relationship between varicocele and infertility is unclear, but several articles have demonstrated that varicocele has

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“…OS can also negatively influence other sperm components (i.e., nucleic acids and proteins), inducing sperm DNA fragmentation (SDF) and low sperm motility [ 43 ]. Furthermore, compared with somatic cells, there is a lack of cytoplasm and poorer antioxidant capacity in mature spermatozoa, thereby rendering it more vulnerable to OS [ 44 ]. Nevertheless, it is entirely possible for sperm suffering from oxidative DNA damage to fertilise an oocyte and thus possibly exert adverse effects on the offspring [ 45 ], especially in the context of ICSI [ 46 ].…”

Section: Origins Of Osmentioning

confidence: 99%

Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review

Yang

Kühn

Kolben

et al. 2020

IJMS

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Assisted reproductive technology (ART) has rapidly developed and is now widely practised worldwide. Both the characteristics of ART (handling gametes/embryos in vitro) and the infertility backgrounds of ART parents (such as infertility diseases and unfavourable lifestyles or diets) could cause increased oxidative stress (OS) that may exert adverse influences on gametogenesis, fertilisation, and foetation, even causing a long-lasting influence on the offspring. For these reasons, the safety of ART needs to be closely examined. In this review, from an ART safety standpoint, the origins of OS are reviewed, and the long-lasting cardiovascular effects and potential mechanisms of OS on the offspring are discussed.

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Introduction

Cited by 4 publications

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Effects of Iron Supplementation on Testicular Function and Spermatogenesis of Iron-Deficient Rats

Effects of Iron Supplementation on Testicular Function and Spermatogenesis of Iron-Deficient Rats

Lycopene improves testicular damage and sperm quality in experimentally induced varicocele: Relationship with apoptosis, hypoxia, and hyperthermia

Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review

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