Introduction

Heravi, Majid M.; Zadsirjan, Vahideh

doi:10.1016/b978-0-12-818584-1.00001-x

Cited by 2 publications

(1 citation statement)

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“…Multi-component reactions (MCRs) can condense at least three reactants into a single synthetic operation to produce the final molecule, which provides greater flexibility, novelty, and efficiency for the rapid access to diverse compounds. This protocol has been successfully applied for the synthesis of various nitrogenous heterocyclic compounds (such as the Biginelli, Hantzsch, Asinger, and isocyanide-based Ugi MCRs) . In recent years, our group has been focusing on constructing various heterocycles by using the MCR strategy and developed a series of efficient methodologies for the preparation of aromatic heterocycles. , As a part of our continuous interest in the heterocycle synthesis, herein we report a simple and efficient method to prepare dibenzoxazepinamines and dibenzothiazepinamines via MCRs (Scheme c).…”

Section: Introductionmentioning

confidence: 99%

Three-Component Synthesis of Dibenzoxazepinamines and Dibenzothiazepinamines under Transition-Metal-Free Conditions

et al. 2021

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A convenient and efficient strategy for the synthesis of dibenzoxazepinamines and dibenzothiazepinamines has been developed. This three-component approach started from 2-nitrobenzaldehydes, 2-aminophenols, and methoxyammonium chlorides under metal-free conditions. The protocol has the advantages of readily available starting materials, simple and facile conditions, gram-scale synthesis, and broad substrate scope, providing an efficient and practical strategy for the preparation of potential drug-active dibenzoxazepinamines and dibenzothiazepinamines in one pot.

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Section: Introductionmentioning

confidence: 99%

Three-Component Synthesis of Dibenzoxazepinamines and Dibenzothiazepinamines under Transition-Metal-Free Conditions

et al. 2021

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Catalytic Function of Cu (I) and Cu (II) in Total Synthesis of Alkaloids

et al. 2021

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Recently, Cu-catalyzed carbon-carbon and carbon (sp 2 )-nitrogen bond formation have attracted much attention. Nowadays, they are widely being applied to the total synthesis of an extensive assortment of natural products with complex structures. Natural products chemistry is a discrete part of chemical research, which has been significant in the history of chemistry, the sourcing of substances in early preclinical drug discovery research, pharmacology and discovery of folk medicine. Alkaloids are a class of natural product that contains at least one nitrogen atom. They have diverse and important physiological effects on humans and other animals. In fact, as many as one-quarter of higher plants are estimated to contain alkaloids, of which several thousand (approximately 12000) different types have so far been identified. In this review, we try underscore the total synthesis of naturally occurring alkaloids in which Cu-promoted reaction is at least one of the vital step. Indeed, in this comprehensive review, the impact of Cu-catalyzed cross-coupling reactions in the total synthesis of natural products with a prominence on the evolution of strategies due to copper catalysis will be generally surveyed.

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Introduction

Cited by 2 publications

References 89 publications

Three-Component Synthesis of Dibenzoxazepinamines and Dibenzothiazepinamines under Transition-Metal-Free Conditions

Three-Component Synthesis of Dibenzoxazepinamines and Dibenzothiazepinamines under Transition-Metal-Free Conditions

Catalytic Function of Cu (I) and Cu (II) in Total Synthesis of Alkaloids

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