Introduction

Czernin, Johannes

doi:10.2967/jnumed.111.097071

Cited by 4 publications

(3 citation statements)

References 15 publications

(9 reference statements)

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“…Dramatic impact of PET-CT on patient management has been recognized by Medicare and Medicaid Services 12. This can be illustrated by the evidence that the course of considerable number of patient treatments (50-60 %) was changed or adjusted on the basis of 68 Ga/PET-CT examinations using somatostatin (SST) ligand analogues in diagnosis and staging of neuroendocrine tumours (NETs) 2, 13.…”

Section: Role Of Pet In Nuclear Medicinementioning

confidence: 99%

Prospective of ⁶⁸Ga-Radiopharmaceutical Development

Velikyan¹

2014

Theranostics

264

249

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Positron Emission Tomography (PET) experienced accelerated development and has become an established method for medical research and clinical routine diagnostics on patient individualized basis. Development and availability of new radiopharmaceuticals specific for particular diseases is one of the driving forces of the expansion of clinical PET. The future development of the 68Ga-radiopharmaceuticals must be put in the context of several aspects such as role of PET in nuclear medicine, unmet medical needs, identification of new biomarkers, targets and corresponding ligands, production and availability of 68Ga, automation of the radiopharmaceutical production, progress of positron emission tomography technologies and image analysis methodologies for improved quantitation accuracy, PET radiopharmaceutical regulations as well as advances in radiopharmaceutical chemistry. The review presents the prospects of the 68Ga-based radiopharmaceutical development on the basis of the current status of these aspects as well as wide range and variety of imaging agents.

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Section: Role Of Pet In Nuclear Medicinementioning

confidence: 99%

Prospective of ⁶⁸Ga-Radiopharmaceutical Development

Velikyan¹

2014

Theranostics

264

249

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“…The hybrid PET-MRI scanners have also entered market providing advantages of MRI over CT in higher soft tissue contrast and absence of radiation dose to the patient. PET has demonstrated efficiency and profitability in individualized patient diagnostics especially in oncology, and its impact on patient management has been recognized by Medicare and Medicaid Services [ 29 ].…”

Section: Infection and Inflammationmentioning

confidence: 99%

“…They accumulate at infection but not sterile inflammation sites. The most thoroughly studied antimicrobial peptide, ubiquicidin UBI [ 29 – 41 ] labelled with 99m Tc [ 199 ], demonstrated promising results in human clinical trials [ 200 , 201 ]. It has the potential for quantification of viable infecting microorganisms and consequently for monitoring the efficacy of antimicrobial therapy in patients.…”

Section: Imaging Infectionmentioning

confidence: 99%

Prospective of⁶⁸Ga Radionuclide Contribution to the Development of Imaging Agents for Infection and Inflammation

Velikyan

2018

Contrast Media & Molecular Imaging

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During the last decade, the utilization of 68Ga for the development of imaging agents has increased considerably with the leading position in the oncology. The imaging of infection and inflammation is lagging despite strong unmet medical needs. This review presents the potential routes for the development of 68Ga-based agents for the imaging and quantification of infection and inflammation in various diseases and connection of the diagnosis to the treatment for the individualized patient management.

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Precision of SPECT/CT Allows the Diagnosis of a Hidden Brodie’s Abscess of the Talus in a Patient with Sickle Cell Disease

Al-Jafar

Al-Shemmeri

et al. 2014

Nucl Med Mol Imaging

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Brodie’s abscess is a rare subacute osteomyelitis that can be found in sickle cell disease along with other bone complications. A 21-year-old female with sickle cell disease was presenting frequently to the medical casualty department for painful vasoocclusive crises and for persistent ankle pain and swelling. Hybrid imaging with single-photon emission computed tomography-computed tomography (SPECT-CT) incidentally revealed Brodie’s abscess in the talus bone of the ankle, causing persisting long-standing pain. SPECT-CT is a modern technology used to scan bone to detect both anatomical and functional abnormalities with high specificity. Brodie’s abscess is a rare bone inflammation that could be a hidden cause of pain and infection in sickle cell disease. Although rare, this lesion requires more attention in patients with sickle cell disease because their immunocompromised status renders them prone to this infection.

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Introduction

Cited by 4 publications

References 15 publications

Prospective of ⁶⁸Ga-Radiopharmaceutical Development

Prospective of ⁶⁸Ga-Radiopharmaceutical Development

Prospective of⁶⁸Ga Radionuclide Contribution to the Development of Imaging Agents for Infection and Inflammation

Precision of SPECT/CT Allows the Diagnosis of a Hidden Brodie’s Abscess of the Talus in a Patient with Sickle Cell Disease

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Introduction

Cited by 4 publications

References 15 publications

Prospective of 68Ga-Radiopharmaceutical Development

Prospective of 68Ga-Radiopharmaceutical Development

Prospective of68Ga Radionuclide Contribution to the Development of Imaging Agents for Infection and Inflammation

Precision of SPECT/CT Allows the Diagnosis of a Hidden Brodie’s Abscess of the Talus in a Patient with Sickle Cell Disease

Contact Info

Product

Resources

About

Prospective of ⁶⁸Ga-Radiopharmaceutical Development

Prospective of ⁶⁸Ga-Radiopharmaceutical Development

Prospective of⁶⁸Ga Radionuclide Contribution to the Development of Imaging Agents for Infection and Inflammation