Introducing the thematic series on transcranial direct current stimulation (tDCS) for motor rehabilitation: on the way to optimal clinical use

Vitório, Rodrigo; Stuart, Samuel; Charvet, Leigh; Godfrey, Alan

doi:10.1186/s12984-019-0507-y

Cited by 6 publications

(7 citation statements)

References 10 publications

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“…6,14 tDCS may increase the blood flow and the amount of oxygen available in the subcortical areas involved with the direct pathway (more automatic movement control). 24,50,51 The facilitation of subcortical, and of direct pathway structures after tDCS, may be explained by the change in cortico-reticular drive and the direct change in the excitability of these structures. 6,18 RF and PPN are structures involved in the preparation and generation of postural responses, which are altered in PD, and may be affected by stimulation of M1 with 2 mA.…”

Section: Discussionmentioning

confidence: 99%

“…Future studies should focus on determining the optimal stimulation parameters (eg, number of sessions, stimulation duration, montage, how long the effects remain, etc) and identifying potential predictors of response to tDCS. 24…”

Section: Discussionmentioning

confidence: 99%

“…Establishing the best parameters of tDCS to improve postural control in people with PD is highly relevant to both clinicians and patients since it might optimize/enhance the beneficial effects already observed for this cohort. 23,24 Thus, the study aimed to analyze the effect of different intensities (1 and 2 mA) of anodal tDCS applied over M1 on postural responses and PFC activity during the habituation to the external perturbation in patients with PD. We hypothesized that tDCS with 1 or 2 mA will positively improve postural control of patients with PD, with shorter recovery time and onset latency, and lower range of CoP 6 compared with sham condition (placebo).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Different Intensities of Transcranial Direct Current Stimulation on Postural Response to External Perturbation in Patients With Parkinson’s Disease

Beretta

Vitório

Nóbrega‐Sousa

et al. 2020

Neurorehabil Neural Repair

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Background Habituation of postural response to perturbations is impaired in people with Parkinson’s disease (PD) due to deficits in cortico-basal pathways. Although transcranial direct current stimulation (tDCS) modulate cortico-basal networks, it remains unclear if it can benefit postural control in PD. Objective To analyze the effect of different intensities of anodal tDCS on postural responses and prefrontal cortex (PFC) activity during the habituation to the external perturbation in patients with PD (n = 24). Methods Anodal tDCS was applied over the primary motor cortex (M1) with 1 mA, 2 mA, and sham stimulation in 3 different sessions (~2 weeks apart) during 20 minutes immediately before the postural assessment. External perturbation (7 trials) was applied by a support base posterior translation (20 cm/s and 5 cm). Primary outcome measures included lower limb electromyography and center of pressure parameters. Measures of PFC activity are reported as exploratory outcomes. Analyses of variance (Stimulation Condition × Trial) were performed. Results Habituation of perturbation was evidenced independent of the stimulation conditions. Both active stimulation intensities had shorter recovery time and a trend for lower cortical activity in the stimulated hemisphere when compared to sham condition. Shorter onset latency of the medial gastrocnemius as well as lower cortical activity in the nonstimulated hemisphere were only observed after 2 mA concerning the sham condition. Conclusions tDCS over M1 improved the postural response to external perturbation in PD, with better response observed for 2 mA compared with 1 mA. However, tDCS seems to be inefficient in modifying the habituation of perturbation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Different Intensities of Transcranial Direct Current Stimulation on Postural Response to External Perturbation in Patients With Parkinson’s Disease

Beretta

Vitório

Nóbrega‐Sousa

et al. 2020

Neurorehabil Neural Repair

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“…A growing body of evidence suggests that transcranial direct current stimulation (tDCS), a low-cost method of non-invasive brain stimulation, could potentially become a clinical tool for PD in the near future [11][12][13][14]. tDCS directs, through scalp electrodes, a constant low amplitude electric current (generally between 1 and 2 mA), which has been shown to modulate excitability in both cortical [15] and subcortical brain areas [16,17].…”

Section: Introductionmentioning

confidence: 99%

Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson’s disease: a systematic review

Beretta

Conceição

Nóbrega‐Sousa

et al. 2020

J NeuroEngineering Rehabil

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Background: Pharmacologic therapy is the primary treatment used to manage Parkinson's disease (PD) symptoms. However, it becomes less effective with time and some symptoms do not respond to medication. Complementary interventions are therefore required for PD. Recent studies have implemented transcranial direct current stimulation (tDCS) in combination with other modalities of interventions, such as physical and cognitive training. Although the combination of tDCS with physical and cognitive training seems promising, the existing studies present mixed results. Therefore, a systematic review of the literature is necessary. Aims: This systematic review aims to (i) assess the clinical effects of tDCS when applied in combination with physical or cognitive therapies in people with PD and; (ii) analyze how specific details of the intervention protocols may relate to findings. Methods: The search strategy detailed the technique of stimulation, population and combined interventions (i.e. cognitive and/or physical training). Only controlled studies were included. Results: Seventeen of an initial yield of 408 studies satisfied the criteria. Studies involved small sample sizes. tDCS protocols and characteristics of combined interventions varied. The reviewed studies suggest that synergistic effects may be obtained for cognition, upper limb function, gait/mobility and posture when tDCS is combined with cognitive and/or motor interventions in PD. Conclusion: The reported results encourage further research to better understand the therapeutic utility of tDCS and to inform optimal clinical use in PD. Future studies in this field should focus on determining optimal stimulation parameters and intervention characteristics for maximal benefits in people with PD.

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Transcranial direct current stimulation for balance rehabilitation in neurological disorders: A systematic review and meta-analysis

Beretta¹,

Santos²,

Orcioli‐Silva³

et al. 2022

Ageing Research Reviews

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Introducing the thematic series on transcranial direct current stimulation (tDCS) for motor rehabilitation: on the way to optimal clinical use

Cited by 6 publications

References 10 publications

Effect of Different Intensities of Transcranial Direct Current Stimulation on Postural Response to External Perturbation in Patients With Parkinson’s Disease

Effect of Different Intensities of Transcranial Direct Current Stimulation on Postural Response to External Perturbation in Patients With Parkinson’s Disease

Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson’s disease: a systematic review

Transcranial direct current stimulation for balance rehabilitation in neurological disorders: A systematic review and meta-analysis

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