Introducing sexual dysfunction in mental care

Gombert, Marie; Ballester, Pura; Segura, Ana; Peiró, Ana M.

doi:10.1080/14740338.2020.1849135

Cited by 6 publications

(3 citation statements)

References 96 publications

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“…There are several factors that can also influence these differences [ 49 , 50 ], such as the connection between hormones [ 51 ], a different pattern of co-prescribed medications, or other gender issues [ 52 , 53 ] that are nowadays undetected [ 54 ]. What is more, differences between males and women in sexual side-effects highlight the need for introducing this component in analgesic AE monitoring [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in Oxycodone/Naloxone vs. Tapentadol in Chronic Non-Cancer Pain: An Observational Real-World Study

et al. 2022

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Despite the large body of research on sex differences in pain, there is a lack of translation to real-world pain management. Our aim was to analyse the sex differences in the analgesic response to oxycodone/naloxone (OXN) and tapentadol (TAP), in comparison with other opioids (OPO) commonly prescribed for chronic non-cancer pain (CNCP). An observational and cross-sectional study was conducted on ambulatory CNCP patients (n = 571). Sociodemographic, clinical (pain intensity, relief, and quality of life), safety (adverse events (AEs), adverse drug reactions), hospital frequentations and pharmacological (morphine equivalent daily dose (MEDD)) variables were collected. Multiple linear regressions were carried out to assess the association between sex and outcomes. Sex differences were observed, with lower female tolerability and higher hospital frequentation, especially in the OXN group (OR AEs report = 2.8 [1.8–4.4], p < 0.001). Here, females showed higher hospital use (23% hospital admission, 30% prescription change, p < 0.05), requiring a higher MEDD (127 ± 103 mg/day, p < 0.05), compared to OXN men. Regardless of the opioid group, CNCP women were significantly older than men (three years), with significantly higher benzodiazepine use (OR = 1.6 [1.1–2.3]), more constipation (OR = 1.34 [0.93–1.90]) and headache (OR = 1.45 [0.99–2.13]) AEs, than men who were more likely to refer sexual dysfunction (OR = 2.77 [1.53–5.01]), and loss of libido (OR = 1.93 [1.22–3.04]). Sex-differences were found related to poorer female drug tolerability and higher hospital resources, even worst in OXN female users. Other differences related to older female ages and benzodiazepine prescription, need to be further analysed from a gender perspective.

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Section: Discussionmentioning

confidence: 99%

Sex Differences in Oxycodone/Naloxone vs. Tapentadol in Chronic Non-Cancer Pain: An Observational Real-World Study

et al. 2022

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“…A common reason for medication non-compliance is sexual dysfunction due to adverse reactions to several psychotropic medications. 4 Most categories of psychotropic drugs (eg, antidepressants, antipsychotics, anxiolytics and mood stabilisers) are reported to be associated with sexual dysfunction. 5 Moreover, psychiatric disorders can manifest as sexual dysfunction, such as hyposexuality in major depressive disorder with anhedonia 6 7 or sexual aversion in anxiety disorder.…”

Section: Introductionmentioning

confidence: 99%

Sexual dysfunction and associated factors in Thai patients with psychiatric disorders

2023

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BackgroundSexual dysfunction is common among patients with psychiatric disorders but might be under-reported due to Asian sociocultural factors. Recognition of sexual dysfunction and associated factors in this vulnerable population would help clinicians properly assess and manage related conditions.AimsWe aimed to examine the prevalence of sexual dysfunction and its associated factors among patients with psychiatric disorders in Thailand.MethodsThis was a cross-sectional study. We enrolled participants aged 18 and older who visited the psychiatry clinic at King Chulalongkorn Memorial Hospital in Bangkok, Thailand between August 2020 and December 2021. Demographic and clinical data were assessed, and all psychiatric disorders and sexual dysfunctions were diagnosed by clinical interview using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Statistical analysis was done to explore the association between sexual dysfunction and related factors.ResultsSexual dysfunction was diagnosed in 101 (50.0%) of the total 202 participants. The mean (standard deviation, SD) age was 30.2 (9.0) years, and the majority of patients were men (54.5%), single (81.2%), employed (47.5%) and had a coexisting depressive disorder (48.0%). Multivariable logistic regression analysis showed a significant association between sexual dysfunction and quality of life, unemployment, and the dosage of antidepressants and benzodiazepines.ConclusionsThe prevalence of sexual dysfunction among this population was relatively high. However, the findings may represent only a portion of affected psychiatric patients for others with sexual dysfunction symptoms but without functional impairment did not meet the diagnostic criteria for sexual dysfunction. Improvement of quality of life and optimising antidepressant/benzodiazepine dosage should be further investigated for promoting sexual function in patients with mental disorders.

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“…In this study, we also found pED patients accompanied by depression and anxiety compared to HCs. Previous literatures have suggested that autonomic arousal and physiological anxiety are not fully correlated with erectile function(Gombert, Ballester, Segura, & Peiró, 2021). Cognitive responses may be of functional signi cance in sexual dysfunction if the correlation between autonomic arousal and other response systems is not complete (Dusenbury, Palm Johansen, Mosack, & Steinke, 2017).…”

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confidence: 99%

Altered functional connectivity of large-scale brain networks in psychogenic erectile dysfunction associated with cognitive impairments

Feng

Dong

Yan

et al. 2023

Preprint

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Several studies have demonstrated that psychogenic erectile dysfunction (pED) patients potentially suffer from cognitive dysfunction. Despite that previous neuroimaging studies have reported abnormal functional connections of brain areas associated with cognitive function in pED, the underlying mechanisms of cognitive dysfunction in pED remain elusive. Large-scale brain networks might shed light on the neuropsychological cognitive functions in pED. The functional connectivity (FC) of large-scale brain networks was calculated in 30 pED patients and 30 healthy controls. The relationship among cognitive functions and altered FC of large-scale brain networks was further explored in pED patients. Our results showed that the decreased FC within visual network, and between visual network and default mode network, visual network and frontoparietal network, and ventral attention and default mode network were found in pED patients. Furthermore, there was the positive correlation between immediate memory score and FC within visual network. And visuospatial score was negatively correlated with decreased FC between ventral attention network and default mode network. Taken together, our findings revealed the relationship between cognitive impairments and altered FC between large-scale brain networks in pED patients, providing the new evidence about the neural mechanisms of cognitive dysfunction in pED patients.

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Introducing sexual dysfunction in mental care

Cited by 6 publications

References 96 publications

Sex Differences in Oxycodone/Naloxone vs. Tapentadol in Chronic Non-Cancer Pain: An Observational Real-World Study

Sex Differences in Oxycodone/Naloxone vs. Tapentadol in Chronic Non-Cancer Pain: An Observational Real-World Study

Sexual dysfunction and associated factors in Thai patients with psychiatric disorders

Altered functional connectivity of large-scale brain networks in psychogenic erectile dysfunction associated with cognitive impairments

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