Introducing GRADE across the NICE clinical guideline program

Thornton, Judith; Alderson, Phil; Tan, Toni; Turner, Claire; Latchem, Sue; Shaw, Elizabeth; Ruiz, Francis; Reken, Stefanie; Mugglestone, M. A.; Hill, Jennifer; Neilson, Julie; Westby, Maggie J; Francis, Karen; Whittington, Craig; Siddiqui, Faisal; Sharma, Tarang; Kelly, Victoria; Ayiku, Lynda; Chamberlain, Kathryn

doi:10.1016/j.jclinepi.2011.12.007

Cited by 61 publications

(54 citation statements)

References 17 publications

(10 reference statements)

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“…105 Applicability is dealt with as part of whether evidence is direct or indirect, and judgement of directness is used to assess the strength of the evidence underlying recommendations. 106 In GRADE, indirectness can arise from one or more of four mechanisms:…”

Section: How Does Grading Of Recommendations Assessment Development mentioning

confidence: 99%

“…130 However, a number of important problems have been identified in using absolute benefit and NNT. In practice, the NNT in particular is not routinely calculated or reported in trials, systematic reviews or guidelines (although the increasing use of the GRADE approach means that guidelines increasingly report net benefit of treatments in a standardised way 105,131,132 ).…”

Section: Using Absolute Benefit Expressed In Terms Of Trial Outcomesmentioning

confidence: 99%

See 1 more Smart Citation

Better guidelines for better care: accounting for multimorbidity in clinical guidelines – structured examination of exemplar guidelines and health economic modelling

Guthrie

Thompson

Dumbreck

et al. 2017

Health Serv Deliv Res

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Health Services and Delivery ResearchISSN 2050-4349 (Print) ISSN 2050-4357 (Online) This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: journals.library@nihr.ac.ukThe full HS&DR archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hsdr. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Services and Delivery Research journalReports are published in Health Services and Delivery Research (HS&DR) if (1) they have resulted from work for the HS&DR programme or programmes which preceded the HS&DR programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors. HS&DR programmeThe Health Services and Delivery Research (HS&DR) programme, part of the National Institute for Health Research (NIHR), was established to fund a broad range of research. It combines the strengths and contributions of two previous NIHR research programmes: the Health Services Research (HSR) programme and the Service Delivery and Organisation (SDO) programme, which were merged in January 2012.The HS&DR programme aims to produce rigorous and relevant evidence on the quality, access and organisation of health services including costs and outcomes, as well as research on implementation. The programme will enhance the strategic focus on research that matters to the NHS and is keen to support ambitious evaluative research to improve health services.For more information about the HS&DR programme please visit the website: http://www.nets.nihr.ac.uk/programmes/hsdr This reportThe research reported in this issue of the journal was funded by the HS&DR programme or one of its preceding programmes as project number 11/2003/27. The contractual start date was in October 2012. The final report began editorial review in July 2015 and was accepted for publication in November 2015. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HS&DR editors and production house have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the final report document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, NETSCC, the HS&DR programme or the Department of Health. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, NETSCC, the HS&DR programme or the Department of Hea...

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Section: How Does Grading Of Recommendations Assessment Development mentioning

confidence: 99%

Section: Using Absolute Benefit Expressed In Terms Of Trial Outcomesmentioning

confidence: 99%

Better guidelines for better care: accounting for multimorbidity in clinical guidelines – structured examination of exemplar guidelines and health economic modelling

Guthrie

Thompson

Dumbreck

et al. 2017

Health Serv Deliv Res

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“…The Guidelines Manual also defines some general principles for modelling in guidelines (Box 4). NICE has adopted the GRADE framework for assessing the quality of clinical evidence within its guidelines programme, 37 and has developed a similar framework 13 for reviewing and presenting cost-effectiveness estimates from published studies or new models.…”

Section: Cost-effectiveness In Nice Guidelinesmentioning

confidence: 99%

Economic modelling of diagnostic and treatment pathways in National Institute for Health and Care Excellence clinical guidelines: the Modelling Algorithm Pathways in Guidelines (MAPGuide) project

Lord

Willis²,

Eatock³

et al. 2013

Health Technology Assessment

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“…To quantify the quality of clinical data, grading systems for the level of evidence (LOE) of clinical studies have been proposed by the Preventative Services Task Force in the United States and by the National Health Service in the United Kingdom [16,26]. The LOE of clinical data has been used to quantify the strength of recommendation for clinical decisions [23] and to develop clinical practice guidelines [9, 12-14, 18, 30].…”

Section: Introductionmentioning

confidence: 99%

Have Levels of Evidence Improved the Quality of Orthopaedic Research?

Cunningham

Harmsen

Kweon

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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Background Since 2003 many orthopaedic journals have adopted grading systems for levels of evidence (LOE). It is unclear if the quality of orthopaedic literature has changed since LOE was introduced. Questions/purposes We asked three questions: (1) Have the overall number and proportion of Level I and II studies increased in the orthopaedic literature since the introduction of LOE? (2) Is a similar pattern seen in individual orthopaedic subspecialty journals? (3) What is the interobserver reliability of grading LOE? Methods We assigned LOE to therapeutic studies published in 2000, 2005, and 2010 in eight major orthopaedic subspecialty journals. Number and proportion of Level I and II publications were determined. Data were evaluated using log-linear models. Twenty-six reviewers (13 residents and 13 attendings) graded LOE of 20 blinded therapeutic articles from the Journal of Bone and Joint Surgery for 2009. Interobserver agreement relative to the Journal of Bone and Joint Surgery was assessed using a weighted kappa.

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Introducing GRADE across the NICE clinical guideline program

Cited by 61 publications

References 17 publications

Better guidelines for better care: accounting for multimorbidity in clinical guidelines – structured examination of exemplar guidelines and health economic modelling

Better guidelines for better care: accounting for multimorbidity in clinical guidelines – structured examination of exemplar guidelines and health economic modelling

Economic modelling of diagnostic and treatment pathways in National Institute for Health and Care Excellence clinical guidelines: the Modelling Algorithm Pathways in Guidelines (MAPGuide) project

Have Levels of Evidence Improved the Quality of Orthopaedic Research?

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