Introducing Genes With Significant Role in Migraine: An Interactomic Approach

Azodi, Mona Zamanian; Tavirani, Mostafa Rezaei; Robati, Reza M.

doi:10.32598/bcn.10.4.363

Cited by 4 publications

(4 citation statements)

References 13 publications

(14 reference statements)

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“…KNG1 is a common protein between central nodes of the migraine network and the first neighbors of ALBIL6 while VEGFA and NF1 like central nodes of the gliosarcoma cancer network to the first neighbors of ALB-IL6 paired proteins. The role of KNG1 in migraine is highlighted by Zamanian-Azodi et al Based on this assessment, KNG1 inhibits nitric oxide synthase 3 (NOS3) which is a hub node in the protein-protein interaction network of migraine ( Zamanian-Azodi et al, 2019 ). Zhang et al suggested VEGFA Fms-related receptor tyrosine kinase 1 (FLT1) and kinase insert domain receptor (KDR) messenger ribonucleic acid (mRNA) expression as prognostic factors in brain tumors ( Zhang et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Introducing Albumin and Interleukin 6 as Common Critical Dysregulated Proteins Between Migraine and Gliosarcoma

Tavirani

Mansouri

Arjmand

et al. 2023

BCN

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Introduction: It is reported that migraine may be risk factor of brain cancers. Since the one of the best ways to assess this possible relationship is molecular mechanism study, here the common central dysregulated proteins between these diseases are investigated via network analysis. Methods: The dysregulated proteins of migraine and gliosarcoma are extracted from STRING database and interacted via Cytoscape software to form two separate networks. Central nodes of the networks are compared to find the common central differentially expressed proteins. First neighbors of the common central proteins are studied. Results: Numbers of 11 hub-bottlenecks for each one of migraine and gliosarcoma cancer networks were identified. Albumin and interleukin 6 as common differentially expressed central proteins were introduced. KNG1, VEGFA, and NF1 the first neighbors of ALB-IL6 were connected to the central nodes of networks of the two studied diseases. Conclusion: Network analysis revealed that ALB and IL6 are common central dysregulate proteins between migraine and brain cancers. There are crucial proteins among the first neighbors of ALB and IL6 which are connected to migraine and gliosarcom.

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Section: Discussionmentioning

confidence: 99%

Introducing Albumin and Interleukin 6 as Common Critical Dysregulated Proteins Between Migraine and Gliosarcoma

Tavirani

Mansouri

Arjmand

et al. 2023

BCN

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“…Of note, the −1415 site is within the CREB1 binding site. CREB1 is a transcription factor that may play a role in migraine pathogenesis [ 66 ]. Some correlations between DNA methylation levels and clinical characteristics in migraineurs were found.…”

Section: Epigenetic Connections Of Cgrpmentioning

confidence: 99%

Epigenetic Connection of the Calcitonin Gene-Related Peptide and Its Potential in Migraine

Fila

Sobczuk

Pawłowska

et al. 2022

IJMS

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The calcitonin gene-related peptide (CGRP) is implicated in the pathogenesis of several pain-related syndromes, including migraine. Targeting CGRP and its receptor by their antagonists and antibodies was a breakthrough in migraine therapy, but the need to improve efficacy and limit the side effects of these drugs justify further studies on the regulation of CGRP in migraine. The expression of the CGRP encoding gene, CALCA, is modulated by epigenetic modifications, including the DNA methylation, histone modification, and effects of micro RNAs (miRNAs), circular RNAs, and long-coding RNAs (lncRNAs). On the other hand, CGRP can change the epigenetic profile of neuronal and glial cells. The promoter of the CALCA gene has two CpG islands that may be specifically methylated in migraine patients. DNA methylation and lncRNAs were shown to play a role in the cell-specific alternative splicing of the CALCA primary transcript. CGRP may be involved in changes in neural cytoarchitecture that are controlled by histone deacetylase 6 (HDAC6) and can be related to migraine. Inhibition of HDAC6 results in reduced cortical-spreading depression and a blockade of the CGRP receptor. CGRP levels are associated with the expression of several miRNAs in plasma, making them useful peripheral markers of migraine. The fundamental role of CGRP in inflammatory pain transmission may be epigenetically regulated. In conclusion, epigenetic connections of CGRP should be further explored for efficient and safe antimigraine therapy.

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“…The common hubs and bottlenecks are recognized as hub bottlenecks. The hub-bottleneck genes are known as the central nodes, which control the main processes related to the molecular events in the studied systems [7][8][9]. In the present study, transcriptomic data about the effect of OA on human intestinal Caco-2 cells were extracted from gene expression omnibus (GEO) and analyzed via PPI network analysis and gene ontology evaluation to find the prominent targeted genes by OA.…”

Section: Introductionmentioning

confidence: 99%

The Main Targets of Okadaic Acid Toxin in Human Intestinal Caco-2 Cells: An Investigation of Biological Systems

Robati,

Razzaghi,

Arjmand

et al. 2024

IJMTFM

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Background: Okadaic acid (OA) is a toxin of polluted shellfish. Consuming the contaminated shellfish is accompanied by diarrhea and paralytic and amnesic disorders. There is a correlation between diarrhea and the consumed OA. Determining the critical targeted genes by OA was the aim of this study. Methods: The transcriptomic data about the effect of OA on human intestinal caco-2 cells were extracted from gene expression omnibus (GEO) and evaluated via the GEO2R program. The significant differentially expressed genes (DEGs) were included in a protein-protein interaction (PPI) network and the central nodes were enriched via gene ontology to find the crucial affected biological terms. Results: Among the 178 significant DEGs plus 50 added first neighbors, four hub-bottleneck genes (ALB, FOS, JUN, and MYC) were determined. Twenty-eight critical biological terms were identified as the dysregulated individuals in response to the presence of OA. “ERK1/2-activator protein-1 (AP-1) complex binds KDM6B promoter” was highlighted as the major class of biological terms. Conclusion: It can be concluded that down-regulation of ALB as a potent central gene leads to impairment of blood homeostasis in the presence of OA. Up-regulation of the other three central genes (JUN, FOS, and MYC) grossly affects the vital pathways in the human body.

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Introducing Genes With Significant Role in Migraine: An Interactomic Approach

Cited by 4 publications

References 13 publications

Introducing Albumin and Interleukin 6 as Common Critical Dysregulated Proteins Between Migraine and Gliosarcoma

Introducing Albumin and Interleukin 6 as Common Critical Dysregulated Proteins Between Migraine and Gliosarcoma

Epigenetic Connection of the Calcitonin Gene-Related Peptide and Its Potential in Migraine

The Main Targets of Okadaic Acid Toxin in Human Intestinal Caco-2 Cells: An Investigation of Biological Systems

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