Introducing EbolaCheck: potential for point-of-need infectious disease diagnosis

Moschos, Sterghios A.

doi:10.1586/14737159.2015.1084228

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Thus, the number of viral genomes to viable virions (log 10 GE/log 10 PFU ratio) for EBOV Yambuka-Ecran was higher than that of the younger EBOV Guinea Makona isolate irrespective of the platform used, but consistently lower on the QuRapID. These results were in line with separate reports 9 , 13 , 50 which have suggested virus more extensively passaged in vitro might produce fewer infectious virions vs. newer isolates, thereby increasing the ratio of genomes to infectious particles in a biofluid.…”

Section: Resultssupporting

confidence: 91%

Field-deployable, quantitative, rapid identification of active Ebola virus infection in unprocessed blood

et al. 2017

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Section: Resultssupporting

confidence: 91%

Field-deployable, quantitative, rapid identification of active Ebola virus infection in unprocessed blood

et al. 2017

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Molecular and point-of-care diagnostics for Ebola and new threats: National POCT policy and guidelines will stop epidemics

Kost

2018

Expert Review of Molecular Diagnostics

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US hospitals that admitted Ebola virus disease (EVD) patients mitigated risk by using point-or-care testing (POCT) for critical support in isolation units. Success proved unequivocally the need for POCT. Additionally, molecular diagnostics have been used to help stop new outbreaks, and even handheld diagnostic solutions are emerging. Areas covered: This update of 'Molecular detection and point-of-care testing in Ebola virus disease and other threats' [Expert Reviews 2015;15(10):1249-1255], assesses the impact of EVD epidemics, documents insights from recent reviews, summarizes evolving POC molecular technologies, presents General Accountability Office (GAO) recommendations, identifies the role of POC Coordinators, and casts a vision for national POCT policies and guidelines. Factual updating comprised summarizing EVD outbreaks including 2017-2018, analyzing reviews and evidence-based publications since the 2014-2016 epidemic, and tabulating published technical and molecular diagnostics. New graphics illustrate POC error mitigation/risk reduction, a framework for national POCT policy and guidelines, modular adaptations for country-specific solutions, and a logic diagram for future progress embedding artificial intelligence. Expert commentary: The USA is still not prepared for highly infectious diseases. Key is lack of community rapid response and resilience, which must be enhanced not via mechanisms distant, but instead by molecular diagnostics directly at critical points of need.

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Recent advances in the development and evaluation of molecular diagnostics for Ebola virus disease

Tembo

Simulundu

Changula

et al. 2019

Expert Review of Molecular Diagnostics

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Introducing EbolaCheck: potential for point-of-need infectious disease diagnosis

Cited by 3 publications

References 26 publications

Field-deployable, quantitative, rapid identification of active Ebola virus infection in unprocessed blood

Field-deployable, quantitative, rapid identification of active Ebola virus infection in unprocessed blood

Molecular and point-of-care diagnostics for Ebola and new threats: National POCT policy and guidelines will stop epidemics

Recent advances in the development and evaluation of molecular diagnostics for Ebola virus disease

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